| Project/Area Number |
24650508
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Fukuyama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | fatty acid / omega-oxidation / alfa-oxidation / Fatty acid / omega oxidation / alfa oxidation / 脂肪酸 / ω酸化 / β酸化 / α酸化 / ボディウェイト / アルコールデヒドロゲナーゼ / 脂肪酸代謝 / ボディーウェイトコントロール |
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| Outline of Final Research Achievements |
In this study, based on the tentative theory that fatty acid omega oxidation is the pathway for emergency such as a starvation, we elucidated the enzymes contribute to this pathway and the physiological function. The first reaction of omega-oxidation is omega-hydroxylation catalyzed by omega-hydroxylases. In this study, we clarified that the hydroxyl group of the fatty acid was oxidized to aldehyde by an alcohol dehydrogenase and subsequently it was oxidized to carboxyl group by an aldehyde dehydrogenase. Furthermore, under low temperature condition, we confirmed fatty acids were metabolized via alfa-oxidation pathway also in addition to omega-oxidation, pruduced dicarboxylic acids which number of carbon are odd secreted in urine.
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