Basic research to overcome resistance to anti-mitotic drugs
| Project/Area Number |
24650616
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Tohoku University |
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Principal Investigator |
TANAKA Kozo 東北大学, 加齢医学研究所, 教授 (00304452)
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| Co-Investigator(Renkei-kenkyūsha) |
ITOH Go 東北大学, 加齢医学研究所, 助教 (60607563)
HIROTA Toru 公益財団法人がん研究会, がん研究所, 部長 (50421368)
YASUI Akira 東北大学, 加齢医学研究所, 教授 (60191110)
KANNO Shinichiro 東北大学, 加齢医学研究所, 講師 (10400417)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | がん治療 / 抗がん剤耐性 / 細胞死 / 細胞周期 |
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| Research Abstract |
We aimed to identify molecules involved in cell death after prolonged mitotic arrest by anti-cancer drugs. When cells depleted of CAMP, a novel molecule we identified, were treated with microtubule inhibitors, we found the acceleration of cell death after mitotic arrest specifically in cancer cell lines. There was a tendency that cancer cell lines showed higher expression of CAMP than normal cell lines, implying that cancer cell survival is dependent on CAMP. Expression of Mcl-1 and Bcl-xL, anti-apoptotic Bcl-2 family members, was decreased in CAMP-depleted cells, suggesting that CAMP can be a target for anti-cancer therapy.
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Report
(3 results)
Research Products
(16 results)
