The role of CDX1 in malignant progression of intestinal tumorigenesis

• Project/Area Number: 24650619
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Tumor biology
• Research Institution: University of Fukui
• Principal Investigator: AOKI Koji 福井大学, 医学部, 教授 (40402862)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 大腸癌 / 悪性化 / 幹細胞性 / 癌幹細胞 / CDX1

Research Abstract

I found that CDX1 and CDX2, intestine-specific transcription factors, suppressed malignant progression of intestinal tumorigenesis. Importantly, CDX1 and CDX2 appeared to inhibit stemness of intestinal tumors, suggesting they were novel suppressors of stemness of colon cancer cells.
We are going to reveal the mechanisms of controlling stemness of colon cancer cells, aiming to identify therapeutic targets to kill colon cancer stem cells.

Research Products

• [Journal Article] In situ differentiation of CD8ααT cells from CD4 T cells in peripheral lymphoid tissues (2012)
  • Author(s): Nambu Y, Hayashi T, Jang KJ, Aoki K, Mano H, Nakano K, Osato M, Takahashi K, Itoh K, Teramukai S, Komori T, Fujita J, Ito Y, Shimizu A, Sugai M
  • Journal Title: Scientific Reports Volume: 2 Pages: 642-642
  • Peer Reviewed
• [Journal Article] In situ differentiation of CD8αα T cells from CD4 T cells in peripheral lymphoid tissues (2012)
  • Author(s): Nambu Y., Hayashi T., Jang KJ, Aoki K., Mano H., Nakano K., Osato M., Takabashi K., Itoh K., Teramukai S., Komon T., Fujita J., Ito Y., Shimizu
  • Journal Title: Scientific Reports Volume: 2 Issue: 1 Pages: 930-930
  • DOI: 10.1038/srep00642
  • Peer Reviewed
• [Presentation] Roles of intestine-specific homeoprotein CDX2 in the intestinal epithelial barrier (2013)
  • Author(s): Aoki K, Iemura S, Okawa K, Tanida I, Kobayashi T, Mimuro H, Takahito S, Sasakawa C, Natume T, Sugai M, Taketo MM
  • Organizer: ST-CREST International Symposium, Frontiers in Immunology and Inflammation : From Molecules to Disease
  • Place of Presentation: Tokyo
  • Year and Date: 2013-02-13
• [Remarks]
  • URL: http://yakuri.med.lab.u-fukui.ac.jp/
• [Patent(Industrial Property Rights)] ATG7変異体を用いたオートファジーの抑制方法 (2012)
  • Inventor(s): 青木耕史、谷田以誠
  • Industrial Property Rights Holder: 青木耕史、谷田以誠
  • Filing Date: 2012-12-21
• [Patent(Industrial Property Rights)] ＡＴＧ７変異株を用いたオートファジーの制御方法 (2012)
  • Inventor(s): 青木耕史、谷田以誠
  • Industrial Property Rights Holder: 福井大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-12-21