| Project/Area Number |
24650624
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
INOUE Masaaki 産業医科大学, 医学部, 非常勤医師 (20330988)
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| Co-Investigator(Kenkyū-buntansha) |
川口 誠 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (50204699)
三浦 裕 名古屋市立大学, 医学(系)研究科(研究院), 准教授 (90285198)
浦本 秀隆 産業医科大学, 医学部, 准教授 (90389445)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ATBF1(ZFHX3) / 肺癌 / 性ホルモン |
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| Research Abstract |
The purpose of this study was to evaluate that sex hormones is involved in the etiology of lung cancers through ATBF1 signaling pathway. High expression of AFBF1 in lung cancer cells showed positive relation to the ERalpha expression. From those results ERalpha signaling can also affect ATBF1 signaling in lung cancer, and those signaling system could involved in prognosis of lung cancer. Next, it is necessary to evaluate whether the ERalpha-ATBF1 signaling involve the sex difference of prognosis using large number of clinical samples, and also analyze the signaling pathway directly in vitro.
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