Biological monitoring system for detection of environmental stress.
| Project/Area Number |
24651048
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Osaka University |
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Principal Investigator |
TODO Takeshi 大阪大学, 医学(系)研究科(研究院), 教授 (90163948)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 損傷応答 / 放射線 / 化学変異原 / メダカ / 化学変異原物質 / 環境変異源 |
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| Research Abstract |
Detection of the environmental pollution is an emerging issue having strong social demand. In this proposal, we proposed establishment of a biological monitoring system for DNA damaging agents, which include radiation and chemical mutagens. Medaka is a small experimental model fish and very suitable for field experiments. We tried to establish a medaka line, which produces fluorescent light responding to DNA damage.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] p53-Dependent suppression of genome instability in germ cells.2014
Author(s)
Otozai S, Ishikawa-Fujiwara T, Oda S, Kamei Y, Ryo H, Sato A, Nomura T, Mitani H, Tsujimura T, Inohara H, Todo T.
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Journal Title
Mutat Res,
Volume: 760
Pages: 24-32
DOI
Related Report
Peer Reviewed
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[Journal Article] Human papillomavirus and p53 mutations in head and neck squamous cell carcinoma among Japanese population.2014
Author(s)
Maruyama H, Yasui T, Ishikawa-Fujiwara T, Morii E, Yamamoto Y, Yoshii T, Takenaka Y, Nakahara S, Todo T, Hongyo T, Inohara H.
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Journal Title
Cancer Sci.
Volume: 105(4)
Issue: 4
Pages: 409-417
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish.2013
Author(s)
Ishikawa T, Okada T, Ishikawa-Fujiwara T, Todo T, Kamei Y, Shigenobu S, Tanaka M, Saito TL, Yoshimura J, Morishita S, Toyoda A, Sakaki Y, Taniguchi Y, Takeda S, Mori K.
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Journal Title
Mol Biol Cell
Volume: 24(9)
Issue: 9
Pages: 1387-1395
DOI
Related Report
Peer Reviewed
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[Journal Article] A molecular clock regulates angiopoietin-like protein 2 expression.2013
Author(s)
Kadomatsu T, Uragami S, Akashi M, Tsuchiya Y, Nakajima H, Nakashima Y, Endo M, Miyata K, Terada K, Todo T, Node K, Oike Y.
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Journal Title
Related Report
Peer Reviewed
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[Presentation] Targeted Inactivation of Rev1 gene2013
Author(s)
Tomoko Ishikawa-Fujiwara, Kumi Nakamura, Yoshihiro Fujikawa, Takeshi Todo
Organizer
The 6^<th> Asia and Oceania Conference on Photobiology
Place of Presentation
Sydney (Australia)
Year and Date
2013-11-11
Related Report
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[Presentation] Targeted Inactivation of Rev1 gene
Author(s)
Tomoko Ishikawa-Fujiwara, Kumi Nakamura, Yoshihiro Fujikawa, Takeshi Todo
Organizer
The 6th Asia and Oceania Conference on Photobiology
Place of Presentation
Sydey (Australia)
Related Report
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