• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Biological monitoring system for detection of environmental stress.

Research Project

Project/Area Number 24651048
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionOsaka University

Principal Investigator

TODO Takeshi  大阪大学, 医学(系)研究科(研究院), 教授 (90163948)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords損傷応答 / 放射線 / 化学変異原 / メダカ / 化学変異原物質 / 環境変異源
Research Abstract

Detection of the environmental pollution is an emerging issue having strong social demand. In this proposal, we proposed establishment of a biological monitoring system for DNA damaging agents, which include radiation and chemical mutagens. Medaka is a small experimental model fish and very suitable for field experiments. We tried to establish a medaka line, which produces fluorescent light responding to DNA damage.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (27 results)

All 2014 2013 2012 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 2 results) Presentation (16 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Imaging plant leaves to determine changes in radioactive contamination status in Fukushima, Japan.2014

    • Author(s)
      Nakajima H, et al.
    • Journal Title

      Health Phys.

      Volume: 106(5) Issue: 5 Pages: 565-570

    • DOI

      10.1097/hp.0000000000000020

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p53-Dependent suppression of genome instability in germ cells.2014

    • Author(s)
      Otozai S, Ishikawa-Fujiwara T, Oda S, Kamei Y, Ryo H, Sato A, Nomura T, Mitani H, Tsujimura T, Inohara H, Todo T.
    • Journal Title

      Mutat Res,

      Volume: 760 Pages: 24-32

    • DOI

      10.1016/j.mrfmmm.2013.12.004

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human papillomavirus and p53 mutations in head and neck squamous cell carcinoma among Japanese population.2014

    • Author(s)
      Maruyama H, Yasui T, Ishikawa-Fujiwara T, Morii E, Yamamoto Y, Yoshii T, Takenaka Y, Nakahara S, Todo T, Hongyo T, Inohara H.
    • Journal Title

      Cancer Sci.

      Volume: 105(4) Issue: 4 Pages: 409-417

    • DOI

      10.1111/cas.12369

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitotic slippage underlies the relationship between p53 dysfunction and the induction of large micronuclei by colcemid.2013

    • Author(s)
      Hashimoto K, et al.
    • Journal Title

      Mutagenesis.

      Volume: 28(4) Issue: 4 Pages: 457-464

    • DOI

      10.1093/mutage/get021

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circadian and Circalunar Clock Interactions in a Marine Annelid.2013

    • Author(s)
      Zantke J, et al.
    • Journal Title

      Cell Rep.

      Volume: 5(1) Issue: 1 Pages: 99-113

    • DOI

      10.1016/j.celrep.2013.08.031

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish.2013

    • Author(s)
      Ishikawa T, Okada T, Ishikawa-Fujiwara T, Todo T, Kamei Y, Shigenobu S, Tanaka M, Saito TL, Yoshimura J, Morishita S, Toyoda A, Sakaki Y, Taniguchi Y, Takeda S, Mori K.
    • Journal Title

      Mol Biol Cell

      Volume: 24(9) Issue: 9 Pages: 1387-1395

    • DOI

      10.1091/mbc.e12-11-0830

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A molecular clock regulates angiopoietin-like protein 2 expression.2013

    • Author(s)
      Kadomatsu T, Uragami S, Akashi M, Tsuchiya Y, Nakajima H, Nakashima Y, Endo M, Miyata K, Terada K, Todo T, Node K, Oike Y.
    • Journal Title

      PloS One

      Volume: 8

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gamma-ray irradiation promotes premature meiosis of spontaneously differentiating testis-ova in the testis of p53-deficient medaka (Oryzias latipes)2012

    • Author(s)
      Yasuda T, Oda S, Li Z, Kimori Y, Kamei Y, Ishikawa T, Todo T, Mitani H
    • Journal Title

      Cell Death Dis

      Volume: 3 Issue: 10 Pages: 1-8

    • DOI

      10.1038/cddis.2012.133

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Circadian regulation of food-anticipatory activity in molecular clock-deficient mice.2012

    • Author(s)
      Takasu NN, et al.
    • Journal Title

      PLoS One

      Volume: 7(11) Issue: 11 Pages: e48892-e48892

    • DOI

      10.1371/journal.pone.0048892

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of urinary bladder ConnexTn43 ana tne circadian clock in coordination of diurnal micturition rhythm2012

    • Author(s)
      Negoro H
    • Journal Title

      Nature Communications

      Volume: 3 Issue: 1 Pages: 809-809

    • DOI

      10.1038/ncomms1812

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 福島シミュレーション実験としての137Csのマウス多世代低線量率内部被曝による子孫での生理的影響2013

    • Author(s)
      中島裕夫、本行忠志、花本敦、福角隆仁、武本憲彦、岡幸子、藤堂剛
    • Organizer
      日本環境変異原学会第42回大会
    • Place of Presentation
      岡山
    • Year and Date
      2013-11-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Targeted Inactivation of DNA photolyase family genes using CRISPR system2013

    • Author(s)
      Tomoko Ishikawa-Fujiwara, Kumi Nakamura, Yoshihiro Fujikawa, Takeshi Todo*
    • Organizer
      The 6^<th> Asia and Oceania Conference on Photobiology
    • Place of Presentation
      Sydney (Australia)
    • Year and Date
      2013-11-11
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Targeted Inactivation of Rev1 gene2013

    • Author(s)
      Tomoko Ishikawa-Fujiwara, Kumi Nakamura, Yoshihiro Fujikawa, Takeshi Todo
    • Organizer
      The 6^<th> Asia and Oceania Conference on Photobiology
    • Place of Presentation
      Sydney (Australia)
    • Year and Date
      2013-11-11
    • Related Report
      2013 Final Research Report
  • [Presentation] ゲノム編集技術(TALEN)を用いたメダカにおけるTLSポリメラーゼ変異体の網羅的作製2013

    • Author(s)
      藤川芳宏、藤原(石川)智子、中村公美、佐久間哲史2)、山本卓、藤堂剛
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      青森
    • Year and Date
      2013-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Genome editing in medaka : targeted inactivation of DNA photolyase family genes using CRISPR system2013

    • Author(s)
      Tomoko Ishikawa-Fujiwara, Yoshihiro Fujikawa, Kumi Nakamura, Takeshi Todo
    • Organizer
      第19回小型魚類研究会
    • Place of Presentation
      仙台
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 人工ヌクレアーゼに夜ゼブラフィッシュ培養細胞の遺伝子変異細胞の作成2012

    • Author(s)
      藤川芳宏、藤原(石川)智子、中村公美、佐久間哲史2)、山本卓、藤堂剛
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] High throughput screening of induced mutations in Medaka TILLING library by Next Generation Sequencer2012

    • Author(s)
      Tomoko Ishikawa-Fujiawara
    • Organizer
      18th Japanese Medaka and Zebrafish Meeting
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Research-status Report
  • [Presentation] ゴカイ Platynereis dumerii 由来Cryptochrome-DASHにおける2つの発色団の結合特性2012

    • Author(s)
      直原 一徳
    • Organizer
      第17回日本光生物学協会年会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] 人工ヌクレアーゼを利用した遺伝子改変によるメダカの損傷応答遺伝子変異体の作製2012

    • Author(s)
      藤川 芳宏
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] メダカTILLINGライブラリーにおける変異体の網羅的スクリーニング2012

    • Author(s)
      藤原(石川)智子
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] 人工ヌクレアーゼによるゼブラフィッシュ培養細胞の遺伝子変異細胞の作製2012

    • Author(s)
      藤川 芳宏
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Targeted Inactivation of DNA photolyase family genes using CRISPR system

    • Author(s)
      Tomoko Ishikawa-Fujiwara, Kumi Nakamura, Yoshihiro Fujikawa, Takeshi Todo
    • Organizer
      The 6th Asia and Oceania Conference on Photobiology
    • Place of Presentation
      Sydey (Australia)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Targeted Inactivation of Rev1 gene

    • Author(s)
      Tomoko Ishikawa-Fujiwara, Kumi Nakamura, Yoshihiro Fujikawa, Takeshi Todo
    • Organizer
      The 6th Asia and Oceania Conference on Photobiology
    • Place of Presentation
      Sydey (Australia)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ゲノム編集技術(CRISPR)を利用したメダカ光回復酵素遺伝子変異体の作製

    • Author(s)
      藤原 石川 智子 et al.
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      ホテルクラウンパレス青森(青森)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ゲノム編集技術(TALEN)を用いたメダカにおけるTLS ポリメラーゼ変異体の網羅的作製

    • Author(s)
      藤川 芳宏 et al.
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      ホテルクラウンパレス青森(青森)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 福島シミュレーション実験としての137Csのマウス多世代低線量率内部被曝による子孫での生理的影響

    • Author(s)
      中島裕夫 et al.
    • Organizer
      日本環境変異原学会第42回大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/radbio/www/index.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi