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Evaluation of health risk of internal exposure with radioactive iodine by molecular imaging

Research Project

Project/Area Number 24651050
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation/Chemicals
Research InstitutionNagasaki University

Principal Investigator

MATSUDA Naoki  長崎大学, 原爆後障害医療研究所, 教授 (00304973)

Co-Investigator(Kenkyū-buntansha) KUDO Takashi  長崎大学, 原爆後障害医療研究所, 教授 (20330300)
NAKAYAMA Morio  長崎大学, 医歯薬学総合研究科(薬学系), 教授 (60164373)
IHARA Makoto  長崎大学, 原爆後障害医療研究所, 助教 (60175213)
OKAICHI Kumio  長崎大学, 原爆後障害医療研究所, 准教授 (80124874)
吉田 正博  長崎大学, 先導生命科学研究支援センター, 助教 (50264247)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords内部被ばく / 放射性ヨウ素 / 分子イメージング / 福島原発事故 / リスクコミュニケーション
Outline of Final Research Achievements

This study aimed to establish an evaluation method of the health effect of internal exposure with radioactive iodine both in vitro and in vivo. Cultured cells isolated from rat thyroid showed several responses to influx of I-131, including cell survival, DNA damage/repair, and signal transduction, in a different manner from that to external exposure with Cs-137 source. Although the SPECT imaging of mouse thyroid was possible by I-131, the quantitative detection of internal exposure for health risk assessment needs further development using additional radio-probes. These results were preliminary but effective in risk communication situation with residents.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (22 results)

All 2015 2014 2013 2012

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 3 results,  Invited: 7 results)

  • [Journal Article] Anticancer activity of Atractylodes lancea (Thunb.) DC in a hamster model and application of PET-CT for early detection and monitoring progression of cholangiocarcinoma.2015

    • Author(s)
      Tullayakorn P, Matsuda N, Karbwang J, Viyanant V, Hirayama K, Na-Bangchang K
    • Journal Title

      Asian Pac J Cancer Prev

      Volume: 16 Issue: 15 Pages: 6279-6284

    • DOI

      10.7314/apjcp.2015.16.15.6279

    • NAID

      120006986860

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Radiocesium concentrations in wild mushrooms collected in Kawauchi Village after the accident at the Fukushima Daiichi Nuclear Power Plant2015

    • Author(s)
      Nakashima K, Orita M, Fukuda N, Taira Y, Hayashida N, Matsuda N, Takamura N
    • Journal Title

      PeerJ

      Volume: 3 Pages: e1427-e1427

    • DOI

      10.7717/peerj.1427

    • NAID

      120006986806

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Plant-derived natural product chemicals could offer protection to the skin from the harmful effects of gamma radiation during cancer radiotherapy.2014

    • Author(s)
      Lukmanul Hakkim F, Miura M, Matsuda N, Alharassi AS, Guillemin G, Yamauchi M, Arivazhagan G, Song H
    • Journal Title

      Int J Low Radiation

      Volume: 9 Issue: 4 Pages: 305-316

    • DOI

      10.1504/ijlr.2014.063414

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Internal radiation exposure dose in Iwaki City, Fukushima Prefecture after the accident at Fukushima Dai-ichi Nuclear Power Plant.2014

    • Author(s)
      Orita M, Hayashida N, Nukui H, Fukuda N, Kudo T, Matsuda N, Fukushima Y, Takamura N
    • Journal Title

      PloS One

      Volume: 9(12) Issue: 12 Pages: e114407-e114407

    • DOI

      10.1371/journal.pone.0114407

    • NAID

      120006986312

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 東京電力福島第一原子力発電所事故 - 残された健康リスクのアセスメントとコントロール.2014

    • Author(s)
      松田尚樹, 森田直子, 三浦美和
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 134 Pages: 135-142

    • NAID

      130003391152

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Internal radioactivity of temporary residents in Fukushima within one year after the radiological accident.2013

    • Author(s)
      Matsuda N, Morita N, Miura M, Yamauchi M, Kudo T, Usa T
    • Journal Title

      J Environ Occup Sci

      Volume: 2 Issue: 3 Pages: 123-130

    • DOI

      10.5455/jeos.20131012104058

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal characteristics of internal radiation exposure in evacuees and first responders after the radiological accident in fukushima.2013

    • Author(s)
      11. Morita N, Miura M, Yoshida M, Kumagai A, Ohtsuru A, Usa T, Kudo T, Takamura N, Yamashita S, Matsuda N.
    • Journal Title

      Radiation Research

      Volume: 80 Issue: 3 Pages: 299-306

    • DOI

      10.1667/rr3372.1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessment of internal exposure doses in Fukushima by a whole body counter within one month after the nuclear power plant accident.2013

    • Author(s)
      Matsuda N, Kumagai A, Ohtsuru A, Morita N, Miura M, Yoshida M, Kudo T, Takamura N, Yamashita S
    • Journal Title

      Radiat Res

      Volume: 179 Issue: 6 Pages: 663-668

    • DOI

      10.1667/rr3232.1

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Initial activities of a radiation emergency medical assistance team to Fukushima from Nagasaki2013

    • Author(s)
      Matsuda N, Yoshida K, Nakashima K, Iwatake S, Morita N, Ohba T, Yusa T, Kumagai A, Ohtsuru A
    • Journal Title

      Radiation Measurements

      Volume: in press Pages: 22-25

    • DOI

      10.1016/j.radmeas.2013.01.026

    • NAID

      120006986129

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] History of internal radiocesium in human body by direct measurements with a whole body counter in Nagasaki University2015

    • Author(s)
      Fukuda N, Matsuda N
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      国立京都国際会館(京都府府京都市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A measurement of radiocesium concentrations in wild mushrooms collected in Kawauchi village after the nuclear power plant accident.2015

    • Author(s)
      Nakashima K, Orita M, Fukuda N, Taira Y, Hayashida N, Matsuda N, Takamura N
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      国立京都国際会館(京都府府京都市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Assessment of internal exposure doses after the Fukushima nuclear power plant accident by a whole body counter in Nagasaki2015

    • Author(s)
      Matsuda N
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      国立京都国際会館(京都府府京都市)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 緊急時被ばく線量評価におけるホールボディカウンター全身スキャンによる甲状腺線量測定の妥当性の検討2014

    • Author(s)
      福田直子, 奥野浩二, 工藤崇, 松田尚樹
    • Organizer
      日本放射線安全管理学会第13回学術大会
    • Place of Presentation
      徳島大学大塚講堂(徳島市)
    • Year and Date
      2014-12-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 体内放射性セシウム量の歴史 ~ 長崎大ホールボディカウンターによる実測結果.2014

    • Author(s)
      福田直子, 松田尚樹
    • Organizer
      日本放射線安全管理学会第13回学術大会
    • Place of Presentation
      徳島大学大塚講堂(徳島市)
    • Year and Date
      2014-12-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 放射線による健康リスク~その生物学的な解釈とアセスメント.2014

    • Author(s)
      松田尚樹
    • Organizer
      第28回日本核医学技術学会九州地方会学術大会特別講演
    • Place of Presentation
      長崎大学良順会館(長崎市)
    • Year and Date
      2014-07-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 放射線生物学の基本と放射線健康リスクの考え方 - 東京電力福島第一原子力発電所事故における健康リスクの評価.2014

    • Author(s)
      松田尚樹
    • Organizer
      日本原子力学会九州支部特別講演会
    • Place of Presentation
      電気ビル本館(福岡市)
    • Year and Date
      2014-05-23 – 2014-06-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 福島原発事故-残された健康リスクのアセスメントとコントロール2013

    • Author(s)
      松田尚樹
    • Organizer
      日本薬学会第133年会シンポジウム
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 太陽紫外線と放射線の違いからリスクを理解する2013

    • Author(s)
      松田尚樹
    • Organizer
      太陽紫外線防御研究委員会第23回シンポジウム
    • Place of Presentation
      神戸商工会議所神商ホール(神戸市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 福島原発事故-残された健康リスクのアセスメントとコントロール2013

    • Author(s)
      松田尚樹
    • Organizer
      日本薬学会第133年会シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ラット甲状腺由来PCCL-3細胞による[131I]NaI取込みとその作用について2012

    • Author(s)
      三浦美和, 花谷拓哉, 高尾秀明, 吉田正博, 松田尚樹
    • Organizer
      日本放射線安全管理学会第11回学術大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] Retrospective assessment of internal doses for short term visitors to Fukushima within one month after the nuclear power plant accident2012

    • Author(s)
      Matsuda N
    • Organizer
      The first NIRS symposium on reconstruction of early internal dose due to the TEPCO Fukushima Daiichi Nuclear Power Station accident
    • Place of Presentation
      千葉
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Radiation crisis in Fukushima, 20112012

    • Author(s)
      matsuda N
    • Organizer
      Union of Risk Management for Preventive Medicine, World Congress
    • Place of Presentation
      London
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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