Study of cell death-inducing effect enhanced by combined use of anatase-type titanium dioxide and a physiologically active substance
| Project/Area Number |
24651054
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
YOSHIMI Yoji 東京理科大学, 理工学部, 助教 (70609362)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEKITA Masahiko 東京理科大学, 理工学部応用生物科学科, 教授 (70138981)
SHINOMIYA Takahisa 東京理科大学, 理工学部応用生物科学科, 教授 (30196414)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 光触媒 / 酸化チタン / 細胞死 / 活性酸素 / 酸化ストレス / 脂質過酸化 / ネクローシス / アポトーシス / ナノパーティクル / 皮膚がん / 紫外線 |
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| Research Abstract |
The present study analyzes the mechanism of cell damage by photocatalytic effect of titanium dioxide, was done for the purpose of basic research in order to help in the treatment of cancer. Research is composed of three modes, 1) to establish the effective induction and measurement method for the cell cytotoxicity, 2) to classify the type of cell death, and 3) to analyze of the induction mechanism of the cell death. It was possible to establish a system in which they have found a condition that injury effectively the cell, to measure. Further, it was suggested that cell death by the photocatalyst is not apoptosis of various features. Furthermore, the lipid peroxidation of the cell membrane is caused remarkably was confirmed. It is considered that cell death by photocatalyst to cause necrosis by membrane collapses ROS generated by photocatalytic effect has prompted the lipid peroxidation of the cell membrane.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Novel tamoxifen derivative Ridaifen-B induces Bcl-2 independent autophagy without estrogen receptor involvement2013
Author(s)
M Takeyoshi, S Sakemoto, I Shiina, K Nakata, K Fujimori, Y Wang, E Umeda, C Watanabe, S Uetake, T Yamori, S Dan, Y Yoshimi, T Shinomiya, M Ikekita
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Journal Title
Biochemical and Biophysical Research Communications
Volume: In press
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Peer Reviewed
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[Presentation] 新規細胞死誘導剤リダイフェンGの作用機構の解析並びに標的分子の同定2012
Author(s)
羽鳥麻奈美, 山本卓, 友光裕子, 椎名勇, 梅田絵梨, 戸田年総, 大篭友博, 岩本真知子, 森田明典, 渡邊千尋, 植竹祥子, 矢守隆夫, 吉見陽児, 四宮貴久, 池北雅彦
Organizer
第85回日本生化学会大会
Place of Presentation
福岡
Related Report
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