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Study of Biological Effect induced by Radiation Damage of non-DNA Molecules

Research Project

Project/Area Number 24651057
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionJapan Atomic Energy Agency

Principal Investigator

FUJII Kentaro  独立行政法人日本原子力研究開発機構, 原子力科学研究部門 先端基礎研究センター, 研究副主幹 (00360404)

Co-Investigator(Kenkyū-buntansha) AKIMITSU Nobuyoshi  東京大学, アイソトープ総合センター, 教授 (40294962)
FUJII Shin-ichiro  独立行政法人産業技術総合研究所, 計測標準研究部門, 主任研究員 (10415739)
KATO Dai  独立行政法人産業技術総合研究所, バイオメディカル研究部門, 主任研究員 (80533190)
TSUKIMOTO Mitsutoshi  東京理科大学, 薬学部, 講師 (70434040)
NARITA Ayumi  独立行政法人日本原子力研究開発機構, 原子力科学研究部門・先端基礎研究センター, 博士研究員 (50633898)
Co-Investigator(Renkei-kenkyūsha) YOKOYA Akinari  独立行政法人日本原子力研究開発機構, 原子力科学研究部門・先端基礎研究センター, 研究主席 (10354987)
NIWA Osamu  独立行政法人産業技術総合研究所, バイオメディカル研究部門, 総括研究主幹 (70392644)
KOJIMA Syuji  東京理科大学, 薬学部, 嘱託教授 (90119579)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords放射光 / 電離放射線 / 非DNA / ATP / 質量分析 / 電気化学分析 / 生物学的効果 / 細胞間情報伝達 / 軟X線 / 生物効果
Research Abstract

ATP (Adenosine tri-phosphate), one of ribonucleic acids, acts as an intra-cellular energy transfer. ATP is also used as a substrate to synthesize messenger RNA and as a ligand of inter-cellular signaling. Damaged ATP produced by ionizing radiations might act as down- or up-regulation of these biological function. In this study, we examined the relation between molecular damage of ATP and its biological activity by using various biological assessments, such as energy donor activity, genetic information transfer, and inter-cellular signaling activity.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (70 results)

All 2014 2013 2012 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results,  Acknowledgement Compliant: 1 results,  Open Access: 2 results) Presentation (49 results) (of which Invited: 4 results)

  • [Journal Article] Purine receptor P2Y<sub>6</sub> mediates cellular response to &gamma;-ray-induced DNA damage2014

    • Author(s)
      S. Ide, N. Nishimaki, M. Tsukimoto, S. Kojima
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 39 Issue: 1 Pages: 15-23

    • DOI

      10.2131/jts.39.15

    • NAID

      130004447108

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Separation and Quantification of RNA Molecules Using Size-Exclusion Chromatography Hyphenated with Inductively Coupled Plasma-Mass Spectrometry2014

    • Author(s)
      Fujii,S., Inagaki, K., Miyashita, S., Groombridge, A. S., Nagasawa, K., Chiba, K., Takatsu, A.
    • Journal Title

      ELECTROPHORESIS

      Volume: 35 Issue: 9 Pages: 1315-1318

    • DOI

      10.1002/elps.201300477

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Bond Cleavage of Adenosine 5’-triphosphate Induced by Monochromatic Soft X-rays2014

    • Author(s)
      K. Fujii, A. Narita, A. Yokoya
    • Journal Title

      Journal of Physics Confefence Series

      Volume: 502 Pages: 12034-12034

    • DOI

      10.1088/1742-6596/502/1/012034

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Time-resolved ICP-MS Measurement: a New Method for Elemental and Multiparametric Analysis of Single Cells2014

    • Author(s)
      宮下振一、Alexander S. Groombridge、藤井紳一郎、高津章子、千葉光一、稲垣和三
    • Journal Title

      Analytical Sciences

      Volume: 30 Issue: 2 Pages: 219-224

    • DOI

      10.2116/analsci.30.219

    • NAID

      130004442256

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamics of low-energy electrons in liquid water with consideration of Coulomb interaction with positively charged water molecules induced by electron collision2014

    • Author(s)
      T. Kai, A. Yokoya, M. Ukai, K. Fujii, M. Higuchi, R. Watanabe
    • Journal Title

      Radiation Physics and Chemistry

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Order effect of repair processes to clustered DNA damage2014

    • Author(s)
      Iyo SHIRAISHI, Masao SUZUKI, Naoya SHIKAZONO, Kentaro FUJII and Akinari YOKOYA
    • Journal Title

      Journal of Radiation Research

      Volume: 55 Issue: suppl 1 Pages: i92-i93

    • DOI

      10.1093/jrr/rrt152

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Order effect of repair processes to clustered DNA damage2014

    • Author(s)
      I. Shiraishi, M. Suzuki, N. Shikazono, K. Fujii, A. Yokoya
    • Journal Title

      Journal of Radiation Research

      Volume: 印刷中 Pages: 137-141

    • DOI

      10.1016/j.cplett.2013.11.026

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 放射線細胞応答における細胞外ヌクレオチドを介したautocrine/paracrine型シグナル伝達の役割2013

    • Author(s)
      月本光俊、小島周二
    • Journal Title

      放射線生物研究

      Volume: 48 Pages: 147-163

    • NAID

      40019758517

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carbon-based Electrode Materials for DNA Electroanalysis2013

    • Author(s)
      D. Kato, O.Niwa
    • Journal Title

      Analytical Sciences

      Volume: 29 Issue: 4 Pages: 385-392

    • DOI

      10.2116/analsci.29.385

    • NAID

      10031165327

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Coupling system of capillary gel electrophoresis with inductively coupled plasma-mass spectrometry for the determination of double stranded DNA2013

    • Author(s)
      S. Fujii, K. Inagaki, S. Miyashita, K. Nagasawa, K. Chiba, A. Takatsu
    • Journal Title

      Metallomics

      Volume: (in press) Issue: 5 Pages: 424-428

    • DOI

      10.1039/c3mt00057e

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] High Sensitive Elemental Analysis of Single Yeast Cells (<i>Saccharomyces cerevisiae</i>) by Time-Resolved Inductively-Coupled Plasma Mass Spectrometry Using a High Efficiency Cell Introduction System2013

    • Author(s)
      Alexander S. Groombridge、宮下振一、藤井紳一郎、長澤圭祐、岡橋哲也、大畑昌輝、梅村知也、高津章子、千葉光一、稲垣和三
    • Journal Title

      Analytical Sciences

      Volume: 29 Issue: 6 Pages: 597-603

    • DOI

      10.2116/analsci.29.597

    • NAID

      10031177781

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and electrochemical performance of nitrogen-doped carbon film formed by electron cyclotron resonance sputtering2013

    • Author(s)
      T. Kamata, D. Kato, S. Hirono, O. Niwa
    • Journal Title

      Analytical Chemistry

      Volume: 85 Issue: 20 Pages: 9845-9851

    • DOI

      10.1021/ac402385q

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA damage by soft X-ray exposure at oxygen K-edge2013

    • Author(s)
      Y. Sugaya, A. Narita, K. Fujii, and A. Yokoya
    • Journal Title

      Journal of Physics:ConferenceSeries

      Volume: 502 Pages: 12040-12040

    • DOI

      10.1088/1742-6596/502/1/012040

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of DNA damage, including abasic sites, in plasmid DNA by carbon ion and X-ray irradiation2013

    • Author(s)
      Shiina, T.
    • Journal Title

      Radiat. Environ. Biophys.

      Volume: 52 Issue: 1 Pages: 99-112

    • DOI

      10.1007/s00411-012-0447-4

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of TRPM2 and TRPV1 cation channels in cellular responses to radiation-induced DNA damage2013

    • Author(s)
      K. Masumoto, M. Tsukimoto, S. Kojima
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: Vol.1830 Issue: 6 Pages: 3382-3390

    • DOI

      10.1016/j.bbagen.2013.02.020

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Observation of cleavage in DNA and nucleotides following oxygen K-shell ionization by measuring X-ray absorption near edge structure2012

    • Author(s)
      K. Fujii, Y. Fukuda, A. Yokoya
    • Journal Title

      International Journal of Radiation Biology

      Volume: Vol. 88 Issue: 12 Pages: 888-894

    • DOI

      10.3109/09553002.2012.703363

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of connexin43 hemichannel in ATP release after γ-irradiation2012

    • Author(s)
      Y. Ohshima, M. Tsukimoto, H. Harada, S. Kojima
    • Journal Title

      Journal of Radiation Research

      Volume: Vol.53 Issue: 4 Pages: 551-557

    • DOI

      10.1093/jrr/rrs014

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autocrine regulation of γ-irradiation-induced DNA damage response via extracellular nucleotides-mediated activation of P2Y6 and P2Y12 receptors2012

    • Author(s)
      N. Nishimaki, M. Tsukimoto, A. Kitami, S. Kojima
    • Journal Title

      DNA Repair

      Volume: Vol.11 Issue: 8 Pages: 657-665

    • DOI

      10.1016/j.dnarep.2012.05.005

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Electrokinetic Parameters for All the DNA bases with Sputter Deposited Nanocarbon Film Electrode2012

    • Author(s)
      D. Kato, M. Sumimoto, A. Ueda, S. Hirono, O. Niwa
    • Journal Title

      Analytical Chemistry

      Volume: Vol.84 Issue: 24 Pages: 10607-10613

    • DOI

      10.1021/ac301964e

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A simulation method based on molecular dynamics due to DNA damage induced by Auger effect.2012

    • Author(s)
      T. Kai, M. Higuchi, K. Fujii, R.Watanabe, A. Yokoya
    • Journal Title

      International Journal of Radiation Biology

      Volume: 88 Issue: 12 Pages: 928-932

    • DOI

      10.3109/09553002.2012.708086

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Modified high performance concentric nebulizer for inductively coupled plasma optical emission spectrometry2012

    • Author(s)
      A. S. Groombridge, K. Inagaki, K. Nagasawa, T. Okahashi, S. Fujii, A. Takatsu, K. Chiba
    • Journal Title

      Journal of Analytical Atomic Spectrometry

      Volume: Vol.27 Issue: 10 Pages: 1787-1793

    • DOI

      10.1039/c2ja30118k

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 放射線細胞応答の新規メカニズムとしてのプリナージック・シグナリング2014

    • Author(s)
      月本光俊
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本(日本薬学会奨励賞受賞講演)
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 放射線に強いバイオ材料について2014

    • Author(s)
      藤井健太郎
    • Organizer
      名古屋大学バイオインターフェース研究会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2014-03-04
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Invited
  • [Presentation] 水和デオキシリボースの軟X線による分解過程2014

    • Author(s)
      藤井健太郎、泉雄大、成田あゆみ、横谷明徳、M.A. Merve du Penhoat, A. Touati, R. Vuilleumioer, M.P. Gaigeot, M.F. Politis
    • Organizer
      第27回日本放射光学会年会
    • Place of Presentation
      広島
    • Year and Date
      2014-01-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 水和デオキシリボース分子の軟X線による分解過程2014

    • Author(s)
      藤井健太郎、泉雄大、成田あゆみ、横谷明徳、M.A. Hervé du Penhoat, A. Touati, R. Vuilleumioer, M.P. Gaigeot, M.F. Politis
    • Organizer
      第27回日本放射光学会年会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] DNA damage responses to external and internal low dose radiation2013

    • Author(s)
      M. Katsura, H. Nakamine, S. Amagasa, N. Akimitsu, K. Miyagawa, Y. Wada
    • Organizer
      29^<th> RBC-NIRS Int. Symp
    • Place of Presentation
      京都
    • Year and Date
      2013-11-28
    • Related Report
      2013 Final Research Report
  • [Presentation] オンライン濃縮CE法を用いたヌクレオチド測定によるメチル化DNAの分析2013

    • Author(s)
      藤井紳一郎、高津章子
    • Organizer
      SCE2013
    • Place of Presentation
      日本女子大
    • Year and Date
      2013-11-15
    • Related Report
      2013 Final Research Report
  • [Presentation]2013

    • Author(s)
      K. Fujii, Y. Izumi, A. Narita, M.A. Merve du Penhoat, A. Touati, R. Vuilleumioer, M.P. Gaigeot, M.F. Politis, A. Yokoya
    • Organizer
      MICROS2013
    • Place of Presentation
      イタリア
    • Year and Date
      2013-10-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 非密封放射性セシウムを使用したヒト正常細胞における低線量内部被ばく実験モデルによるDNA損傷応答の解析2013

    • Author(s)
      桂真理、渡邉和則、石崎梓、秋光信佳、天笠翔太、垰和之、和田洋一郎、児玉龍彦、宮川清、井尻憲一
    • Organizer
      日本放射線影響学会第56回年会
    • Place of Presentation
      青森
    • Year and Date
      2013-10-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 軟X線による水和デオキシリボースの分解過程2013

    • Author(s)
      藤井健太郎、泉雄大、成田あゆみ、横谷明徳
    • Organizer
      第56回日本放射線化学討論会
    • Place of Presentation
      広島大
    • Year and Date
      2013-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 緑内障性視神経萎縮におけるDNA損傷応答の役割2013

    • Author(s)
      桂真理、山岸麗子、仲峰宏政、天笠翔太、秋光信佳、曽根秀子、宮川清、和田洋一郎、相原一
    • Organizer
      第24回日本緑内障学会、眼薬理学会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2013-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Observation of decomposition ofATPinduced by soft X-ray using X-ray absorption spectroscopy2013

    • Author(s)
      K. Fujii, S. Fujii, D. Kato, M. Tsukimoto, N. Akimitsu, A. Narita, T. Nakajima, S. Ide, S.K. Abduc, S. Kojima, O. Niwa, A. Yokoya
    • Organizer
      LPBMS2013
    • Place of Presentation
      つくば
    • Year and Date
      2013-08-29
    • Related Report
      2013 Final Research Report
  • [Presentation] RNA Analysis Utilizing Size-exclusion Chromatography2013

    • Author(s)
      藤井紳一郎、柴山祥枝、高津章子
    • Organizer
      EuroAnalysis2013
    • Place of Presentation
      ポーランド
    • Year and Date
      2013-08-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 軟X線でみた放射線の生物影響2013

    • Author(s)
      藤井健太郎
    • Organizer
      日本磁気学会第190回研究会
    • Place of Presentation
      中央大学
    • Year and Date
      2013-05-26
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Invited
  • [Presentation] ATPシグナリングを介したγ線誘発DNA損傷修復でのTRPチャネルの関与2013

    • Author(s)
      小島周二、増本佳那子、月本光俊
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] RNA analysis utilizing size-exclusion chromatography hyphenated with ICP-MS2013

    • Author(s)
      S. Fujii, K. Nagasawa, A.- S. Groombridge, K. Inagaki, K. Chiba, A. Takatsu
    • Organizer
      2013 European Winter Conference on Plasma Spectrochemistry
    • Place of Presentation
      ポーランド
    • Year and Date
      2013-02-24
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトES細胞由来の神経分化モデルを用いた低および中線量放射線影響の解析2013

    • Author(s)
      仲峰宏政、桂真理、曽勤、曽洋、鍜冶利幸、曽根秀子、秋光信佳
    • Organizer
      第56回日本放射線影響学会
    • Place of Presentation
      ホテルサンパレス青森
    • Related Report
      2013 Annual Research Report
  • [Presentation] 低酸素誘導神経細胞死における53BP1の役割2013

    • Author(s)
      天笠翔太、桂真理、秋光信佳、相原一、宮川清、和田洋一郎
    • Organizer
      第56回日本放射線影響学会
    • Place of Presentation
      ホテルサンパレス青森
    • Related Report
      2013 Annual Research Report
  • [Presentation] 非密封放射性セシウムを使用したヒト正常細胞における低線量内部被ばく実験モデルによるDNA損傷応答の解析2013

    • Author(s)
      桂真理、渡邉和則、石崎梓、秋光信佳、天笠翔太、垰和之、和田洋一郎、児玉龍彦、宮川清、井尻憲一
    • Organizer
      第56回日本放射線影響学会
    • Place of Presentation
      ホテルサンパレス青森
    • Related Report
      2013 Annual Research Report
  • [Presentation] 網膜神経節細胞におけるヒストンH4K20メチル化と53BP1の役割2013

    • Author(s)
      桂真理、天笠翔太、山岸麗子、相原一、児玉龍彦、和田洋一郎、秋光信佳、宮川清
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
  • [Presentation] DNA damage responses to external and internal low dose radiation2013

    • Author(s)
      M. Katsura, H. Nakamine, S. Amagasa, N. Akimitsu, K. Miyagawa, Y. Wada
    • Organizer
      29th RBC-NIRS INTERNATIONAL SYMPOSIUM
    • Place of Presentation
      コープ・イン・京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 緑内障性視神経萎縮におけるDNA損傷応答の役割2013

    • Author(s)
      桂真理、山岸麗子、仲峰宏政、天笠翔太、秋光信佳、曽根秀子、宮川清、和田洋一郎、相原一
    • Organizer
      第24回日本緑内障学会、眼薬理学会
    • Place of Presentation
      京王プラザホテル
    • Related Report
      2013 Annual Research Report
  • [Presentation] Decomposition of Hydrated Deoxyribose by Exposure to Soft X-rays2013

    • Author(s)
      K. Fujii, Y. Izumi, A. Narita, M.A. Hervé du Penhoat, A. Touati, R. Vuilleumioer, M.P. Gaigeot, M.F. Politis, A. Yokoya
    • Organizer
      16th International Symposium on Microdosimetry
    • Place of Presentation
      Treviso(Italy)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Observation of decomposition of ATP induced by soft X-ray using X-ray absorption spectroscopy2013

    • Author(s)
      K. Fujii, S. Fujii, D. Kato, M. Tsukimoto, N. Akimitsu, A. Narita, T. Nakajima, S. Ide, S. K. Abdue, S. Kojima, O. Niwa, A. Yokoya
    • Organizer
      Light Particle Beams in Materials Science 2013
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 軟X線による水和デオキシリボースの分解過程2013

    • Author(s)
      藤井健太郎、泉雄大、成田あゆみ、横谷明徳
    • Organizer
      第56回日本放射線化学会討論会
    • Place of Presentation
      広島大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] サイズ排除クロマトグラフィを用いたRNA分析2012

    • Author(s)
      藤井紳一郎,長澤圭佑, G.-A. Simon,稲垣和三,高津章子
    • Organizer
      日本分析化学会第61回年会
    • Place of Presentation
      金沢大
    • Year and Date
      2012-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation]2012

    • Author(s)
      K. Fujii, S. Fujii, D. Kato, M. Tsukimoto, N. Akimitsu, A. Narita, T. Nakajima, S. Ide, S.K. Abduc, S. Kojima, O. Niwa, A. Yokoya
    • Organizer
      ICESS-12
    • Place of Presentation
      St-Malo(France)
    • Year and Date
      2012-09-18
    • Related Report
      2013 Final Research Report
  • [Presentation] X線マイクロビームを用いた細胞表面ATPレベル変化の解析2012

    • Author(s)
      月本光俊、北見彰啓、大島康宏、本間拓二郎、鈴木明菜、前田宗利、宇佐美徳子、小林克己、小島周二
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大
    • Year and Date
      2012-09-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Sputtered nanocarbon film electrode for detecting DNA molecules2012

    • Author(s)
      D. Kato, S. Fujii, A. Takatsu, S. Hirono, O. Niwa
    • Organizer
      ACS 244^<th> Nat. Meet
    • Place of Presentation
      フィラデルフィア
    • Year and Date
      2012-08-19
    • Related Report
      2013 Final Research Report
  • [Presentation]2012

    • Author(s)
      M. Tsukimoto
    • Organizer
      1st INTERNATIONAL POSTGRADUATE CONFERENCE ON PHARMACEUTICAL SCIENCES 2012
    • Place of Presentation
      マレーシア
    • Year and Date
      2012-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Involvement of Purinergic Signaling in DNA Damage Response afterγ-Ray Irradiation2012

    • Author(s)
      N. Nishimaki, M. Tsukimoto, A. Kitami, S. Kojima
    • Organizer
      Purine2012
    • Place of Presentation
      九州大学
    • Year and Date
      2012-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] スパッタナノカーボン薄膜電極における全核酸塩基の電気化学特性2012

    • Author(s)
      加藤大、隅本倫徳、上田晃生、廣野滋、丹羽修
    • Organizer
      第72回分析化学討論会
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-05-20
    • Related Report
      2013 Final Research Report
  • [Presentation] オンライン濃縮CE法を用いたヌクレオチド測定によるメチル化DNAの分析

    • Author(s)
      藤井紳一郎、高津章子
    • Organizer
      SCE2013
    • Place of Presentation
      日本女子大(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] RNA Analysis Utilizing Size-exclusion Chromatography

    • Author(s)
      藤井紳一郎、柴山祥枝、高津章子
    • Organizer
      Euroanalysis2013
    • Place of Presentation
      ワルシャワ(ポーランド)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 陰イオン交換カラムを用いた高速液体クロマトグラフィーによるDNAの分析

    • Author(s)
      柴山祥枝、藤井紳一郎、高津章子
    • Organizer
      第73回分析化学討論会
    • Place of Presentation
      北大(函館)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 放射線細胞応答の新規メカニズムとしてのプリナージック・シグナリング

    • Author(s)
      月本光俊
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] スパッタナノカーボン薄膜電極における全核酸塩基の電気化学特性

    • Author(s)
      加藤大、隅本倫徳、上田晃生、廣野滋、丹羽 修
    • Organizer
      第72回分析化学討論会
    • Place of Presentation
      鹿児島大学(鹿児島県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Variation in DNA damage induced by monochromatic soft X-rays in the energy region of oxygen K-edge

    • Author(s)
      Y. Sugaya, T. Shiina, I. Shiraishi, K. Fujii, A. Yokoya
    • Organizer
      12th International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Courtyard Prague Flora(チェコ)
    • Related Report
      2012 Research-status Report
  • [Presentation] Involvement of Purinergic Signaling in DNA Damage Response after γ-Ray Irradiation

    • Author(s)
      N. Nishimaki, M. Tsukimoto, A. Kitami, S. Kojima
    • Organizer
      Purine2012
    • Place of Presentation
      九州大学(福岡県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Extracellular nucleotides-mediated autocrine/paracrine signalling (purigenic signalling)

    • Author(s)
      M. Tsukimoto
    • Organizer
      1st INTERNATIONAL POSTGRADUATE CONFERENCE ON PHARMACEUTICAL SCIENCES 2012 (iPoPS 2012)
    • Place of Presentation
      Universiti Teknologi MARA (マレーシア)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Sputtered nanocarbon film electrode for detecting DNA molecules

    • Author(s)
      D. Kato, S. Fujii, A. Takatsu, S. Hirono, O. Niwa
    • Organizer
      ACS 244th National Meeting
    • Place of Presentation
      Philadelphia(アメリカ)
    • Related Report
      2012 Research-status Report
  • [Presentation] X線マイクロビームを用いた細胞表面ATPレベル変化の解析

    • Author(s)
      月本光俊、北見彰啓、大島康宏、本間拓二郎、鈴木明菜、前田宗利、宇佐美徳子、小林克己、小島周二
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 酸素K殻イオン化エネルギー領域の軟X線照射によるDNA損傷の収率変化

    • Author(s)
      菅谷雄基、成田あゆみ、椎名卓也、白石伊世、藤井健太郎、横谷明徳
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2012 Research-status Report
  • [Presentation] X-ray Absorption Near Edge Structure of ATP Thin Film Irradiated with Soft X-rays

    • Author(s)
      K. Fujii, S. Fujii, D. Kato, M. Tsukimoto, N. Akimitsu, A. Narita, T. Nakajima, S. Ide, S.K. Abduc, K. Shuji, O. Niwa, A. Yokoya
    • Organizer
      12th International Congress of Electronic Spectroscopy and Structure
    • Place of Presentation
      Palais des Congres-Saint-Malo(フランス)
    • Related Report
      2012 Research-status Report
  • [Presentation] Orientation-controlled Surface Immobilization of Alkyl Molecules

    • Author(s)
      A. Narita, Y. Baba, T. Sekiguchi, I. Shimoyama, N. Hirao, T. Yaita
    • Organizer
      12th International Congress of Electronic Spectroscopy and Structure
    • Place of Presentation
      Palais des Congres-Saint-Malo(フランス)
    • Related Report
      2012 Research-status Report
  • [Presentation] サイズ排除クロマトグラフィを用いたRNA分析

    • Author(s)
      藤井 紳一郎, 長澤 圭佑, Groombridge Alexander Simon, 稲垣 和三, 高津 章子
    • Organizer
      日本分析化学会第61年会
    • Place of Presentation
      金沢大学(石川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 酸素K殻XANES領域の軟X線照射によるDNA損傷の収率変化

    • Author(s)
      菅谷雄基、成田あゆみ、椎名卓也、白石伊世、藤井健太郎、横谷明徳
    • Organizer
      第26回日本放射光学会年会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2012 Research-status Report
  • [Presentation] DNA薄膜のNEXAFSスペクトル

    • Author(s)
      藤井健太郎、小林英一、横谷明徳、岡島敏浩
    • Organizer
      第26回日本放射光学会年会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2012 Research-status Report
  • [Presentation] RNA analysis utilizing size-exclusion chromatography hyphenated with ICP-MS

    • Author(s)
      S. Fujii, K. Nagasawa, A.S. Groombridge, K. Inagaki, K. Chiba A. Takatsu
    • Organizer
      2013 European Winter Conference on Plasma Spectrochemistry
    • Place of Presentation
      クラコー(ポーランド)
    • Related Report
      2012 Research-status Report
  • [Presentation] ATPシグナリングを介したγ線誘発DNA損傷修復でのTRPチャネルの関与

    • Author(s)
      小島周二、増本佳那子、月本光俊
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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