Study of Biological Effect induced by Radiation Damage of non-DNA Molecules
Project/Area Number |
24651057
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Risk sciences of radiation/Chemicals
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Research Institution | Japan Atomic Energy Agency |
Principal Investigator |
FUJII Kentaro 独立行政法人日本原子力研究開発機構, 原子力科学研究部門 先端基礎研究センター, 研究副主幹 (00360404)
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Co-Investigator(Kenkyū-buntansha) |
AKIMITSU Nobuyoshi 東京大学, アイソトープ総合センター, 教授 (40294962)
FUJII Shin-ichiro 独立行政法人産業技術総合研究所, 計測標準研究部門, 主任研究員 (10415739)
KATO Dai 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 主任研究員 (80533190)
TSUKIMOTO Mitsutoshi 東京理科大学, 薬学部, 講師 (70434040)
NARITA Ayumi 独立行政法人日本原子力研究開発機構, 原子力科学研究部門・先端基礎研究センター, 博士研究員 (50633898)
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Co-Investigator(Renkei-kenkyūsha) |
YOKOYA Akinari 独立行政法人日本原子力研究開発機構, 原子力科学研究部門・先端基礎研究センター, 研究主席 (10354987)
NIWA Osamu 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 総括研究主幹 (70392644)
KOJIMA Syuji 東京理科大学, 薬学部, 嘱託教授 (90119579)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 放射光 / 電離放射線 / 非DNA / ATP / 質量分析 / 電気化学分析 / 生物学的効果 / 細胞間情報伝達 / 軟X線 / 生物効果 |
Research Abstract |
ATP (Adenosine tri-phosphate), one of ribonucleic acids, acts as an intra-cellular energy transfer. ATP is also used as a substrate to synthesize messenger RNA and as a ligand of inter-cellular signaling. Damaged ATP produced by ionizing radiations might act as down- or up-regulation of these biological function. In this study, we examined the relation between molecular damage of ATP and its biological activity by using various biological assessments, such as energy donor activity, genetic information transfer, and inter-cellular signaling activity.
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Report
(3 results)
Research Products
(70 results)
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[Journal Article] Separation and Quantification of RNA Molecules Using Size-Exclusion Chromatography Hyphenated with Inductively Coupled Plasma-Mass Spectrometry2014
Author(s)
Fujii,S., Inagaki, K., Miyashita, S., Groombridge, A. S., Nagasawa, K., Chiba, K., Takatsu, A.
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Journal Title
ELECTROPHORESIS
Volume: 35
Issue: 9
Pages: 1315-1318
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 水和デオキシリボースの軟X線による分解過程2014
Author(s)
藤井健太郎、泉雄大、成田あゆみ、横谷明徳、M.A. Merve du Penhoat, A. Touati, R. Vuilleumioer, M.P. Gaigeot, M.F. Politis
Organizer
第27回日本放射光学会年会
Place of Presentation
広島
Year and Date
2014-01-11
Related Report
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[Presentation] 水和デオキシリボース分子の軟X線による分解過程2014
Author(s)
藤井健太郎、泉雄大、成田あゆみ、横谷明徳、M.A. Hervé du Penhoat, A. Touati, R. Vuilleumioer, M.P. Gaigeot, M.F. Politis
Organizer
第27回日本放射光学会年会
Place of Presentation
広島
Related Report
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[Presentation]2013
Author(s)
K. Fujii, Y. Izumi, A. Narita, M.A. Merve du Penhoat, A. Touati, R. Vuilleumioer, M.P. Gaigeot, M.F. Politis, A. Yokoya
Organizer
MICROS2013
Place of Presentation
イタリア
Year and Date
2013-10-22
Related Report
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[Presentation] Observation of decomposition ofATPinduced by soft X-ray using X-ray absorption spectroscopy2013
Author(s)
K. Fujii, S. Fujii, D. Kato, M. Tsukimoto, N. Akimitsu, A. Narita, T. Nakajima, S. Ide, S.K. Abduc, S. Kojima, O. Niwa, A. Yokoya
Organizer
LPBMS2013
Place of Presentation
つくば
Year and Date
2013-08-29
Related Report
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[Presentation] Observation of decomposition of ATP induced by soft X-ray using X-ray absorption spectroscopy2013
Author(s)
K. Fujii, S. Fujii, D. Kato, M. Tsukimoto, N. Akimitsu, A. Narita, T. Nakajima, S. Ide, S. K. Abdue, S. Kojima, O. Niwa, A. Yokoya
Organizer
Light Particle Beams in Materials Science 2013
Place of Presentation
つくば国際会議場
Related Report
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[Presentation]2012
Author(s)
K. Fujii, S. Fujii, D. Kato, M. Tsukimoto, N. Akimitsu, A. Narita, T. Nakajima, S. Ide, S.K. Abduc, S. Kojima, O. Niwa, A. Yokoya
Organizer
ICESS-12
Place of Presentation
St-Malo(France)
Year and Date
2012-09-18
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[Presentation] X-ray Absorption Near Edge Structure of ATP Thin Film Irradiated with Soft X-rays
Author(s)
K. Fujii, S. Fujii, D. Kato, M. Tsukimoto, N. Akimitsu, A. Narita, T. Nakajima, S. Ide, S.K. Abduc, K. Shuji, O. Niwa, A. Yokoya
Organizer
12th International Congress of Electronic Spectroscopy and Structure
Place of Presentation
Palais des Congres-Saint-Malo(フランス)
Related Report
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