Can tubulin be a novel target of toxicity of environmental chemicals ?
| Project/Area Number |
24651061
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
KOTAKE Yaichiro 広島大学, 医歯薬保健学研究院(薬), 准教授 (20335649)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | チューブリン / 環境化学物質 / ユビキチン化 / ユビキチン化阻害 |
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| Research Abstract |
Tubulin as a target of toxicity was limited to the case of disturbance of polimerization/depolymerization, and it was not expected that tubulin is a target in other cases. In the present study, we focused on tubulin as a target of toxicity and searched chemicals acting on tubulin. When we examined the effects of environmental chemicals on acetylation and ubiquitination of tubulin, we found chemicals inhibiting tubulin ubiquitination. Life extention of tubulin accompanied with the inhibition of ubiquitination will lead to cytotoxicity, and it raises the possibility that some kinds of environmental chemicals acts on tubulin and exerts the toxicity.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes2012
Author(s)
Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Uramaru N, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S
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Journal Title
Drug Metab Dispos
Volume: 40(12)
Issue: 12
Pages: 2267-72
DOI
Related Report
Peer Reviewed
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