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Effects of Environmental Chemicals on Fetal Blood Brain Barrier

Research Project

Project/Area Number 24651062
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionKumamoto University

Principal Investigator

MIYAZAKI Wataru  熊本大学, 生命科学研究部, 助教 (90512278)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords環境化学物質 / 血液脳関門
Research Abstract

Environmental chemicals cause several adverse effects on developing brain of fetus. These effects may be caused by direct action of the chemicals to neural cells, but also there is a possibility that the effects are caused by indirect action of them, for example through disruption of blood brain barrier: BBB. In this study, we used in vitro model of BBB and analyzed the effects of the chemicals on BBB using dioxin as model chemical.
The exposure of dioxin caused a distraction of BBB permeability in dose dependently. Moreover, dioxin easily passed through BBB and increased the expression of drug metabolizing enzyme; CYP.
These results suggested that BBB disruption were caused by environmental chemicals, dioxin, and the adverse effects might cause abnormal brain development.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (1 results)

All Other

All Remarks (1 results)

  • [Remarks]

    • URL

      http://kumadai-publich.com

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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