| Project/Area Number |
24651065
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Risk sciences of radiation/Chemicals
|
|---|
| Research Institution | National Institute of Health Sciences |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | トキシコロジー / エピジェネティック毒性 |
|---|
| Research Abstract |
To advance the research for "epigenetic toxicity", which is thought to be the mechanism for the delayed toxic effects of chemicals, a new technique for editing DNA methylation on the target DNA sequence was tried to develop in this study. For that, "DNA binding protein-nuclease" techniques which are in the stage of practical use, was applied. In addition, an original idea to achieve the specificity comparable to PCR technique was also applied. Though preliminary, data indicating the possibility for the successful development of the technique was obtained.
|
