| Project/Area Number |
24651106
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Quantum beam science
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
SHINADA Takahiro 独立行政法人産業技術総合研究所, ナノエレクトロニクス研究部門, 研究部門付 (30329099)
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| Co-Investigator(Kenkyū-buntansha) |
ASAHI Toru 早稲田大学, 先進理工学部, 教授 (80222595)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ドーピング / イオン注入 / 細胞機能修飾 / イオンビーム |
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| Research Abstract |
A novel heavy-metal implantation method for living cells using focused ion-beam (FIB) were proposed. We performed Au and As ion doping into living cells by using the FIB implantation method; then intracellular level of adenosine triphosphate (ATP) molecule, which is the energy storing molecule for organisms, was evaluated. The ATP level of the implanted cells was found to be modified compared with that of the non-implanted control cells. Our ion implantation technique may be a more accurate tool to quantitatively elucidate the dose-dependent effects of dopants than the conventional methods.
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