| Project/Area Number |
24651135
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOMATSU Naoki 滋賀医科大学, 医学部, 准教授 (30253008)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ナノ材料解析・評価 / 生体内イメージング |
|---|
| Research Abstract |
In vivo application of nanodaimond (ND) by polyglycerol hydrophilic covering was succeeded, and the diametrical selection caused a further success in passive targeting.
RGD-peptide addition to ND (ND-RGD) could allow actiive targeting to cancer cells, and further, ester linkage between anticancer agent (CDDP) and ND-RGD could specifically enhance the cell death of U-87MG cells, which bare integrin aVb3. Such strategy as CDDP-ND-RGD can succeed anti-cancer active targeting therapy to eliminate non-specific CDDP toxicities, and to improve the cancer-specificity of the drug.
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