A challenge to apply nanodiamond into clinical medicine

• Project/Area Number: 24651135
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: Shiga University of Medical Science
• Principal Investigator: CHANO Tokuhiro 滋賀医科大学, 医学部, 准教授 (40346028)
• Co-Investigator(Renkei-kenkyūsha): KOMATSU Naoki 滋賀医科大学, 医学部, 准教授 (30253008)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ナノ材料解析・評価 / 生体内イメージング

Research Abstract

In vivo application of nanodaimond (ND) by polyglycerol hydrophilic covering was succeeded, and the diametrical selection caused a further success in passive targeting.
RGD-peptide addition to ND (ND-RGD) could allow actiive targeting to cancer cells, and further, ester linkage between anticancer agent (CDDP) and ND-RGD could specifically enhance the cell death of U-87MG cells, which bare integrin aVb3. Such strategy as CDDP-ND-RGD can succeed anti-cancer active targeting therapy to eliminate non-specific CDDP toxicities, and to improve the cancer-specificity of the drug.

Research Products

• [Journal Article] Platinum on nanodiamond : A promising prodrug conjugated with stealth polyglycerol, targeting peptide, and acid-responsive antitumor drug (2014)
  • Author(s): Zhao L, Xu YH, Qin H, Abe S, Akasaka T, Chano T, Watari F, Komatsu N, Chen X.
  • Journal Title: Adv Funct Mater Volume: (In press)
  • Peer Reviewed
• [Journal Article] Glucose deprivation induces G2/M transition-arrest and cell death in N-GlcNAc2-modified protein-producing renal carcinoma cells (2014)
  • Author(s): Isono T, Chano T, Kitamura A, Yuasa T.
  • Journal Title: PLoS One Volume: 9(5)
  • Peer Reviewed
• [Journal Article] Study of Global Transcriptional Changesof N-G1cNAc2 Proteins-Producing T24 Bladder Carcinoma Cells under Glucose Deprivation (2014)
  • Author(s): Isono T, Chano T, Okabe H, Suzaki M.
  • Journal Title: PLoS One Volume: 8(4)
  • Peer Reviewed
• [Journal Article] Platinum on nanodiamond: A promising prodrug conjugated with stealth polyglycerol, targeting peptide, and acid-responsive antitumor drug. (2014)
  • Author(s): Zhao L, Xu YH, Qin H, Abe S, Akasaka T, Chano T, Watari F, Komatsu N, Chen X.
  • Journal Title: Adv Funct Mater. Volume: 24
• [Journal Article] Association of p62/SQSTM1 excess and oral carc inogenes i s (2013)
  • Author(s): Inui T, Chano T, Takikita M, Nishikawa M, Yamamoto G, Okabe H.
  • Journal Title: PLoS One Volume: 8(9)
  • Peer Reviewed
• [Journal Article] Preparation of mouse monoclonal antibody for RB1CC1 and its clinical application (2012)
  • Author(s): Hama Y, Chano T, Inui T, Matsumoto K, Okabe H.
  • Journal Title: PLoS One Volume: 7(3)
  • Peer Reviewed
• [Journal Article] Therapeutic potential of SOX2 inhibition in embryonal carcinoma (2012)
  • Author(s): Ushida H, Chano T, Minami K, Kita H, Kawakami T, Okabe H, Okada Y, Okamoto K.
  • Journal Title: J Urology Volume: 187(5) Pages: 1876-1881
  • Peer Reviewed
• [Journal Article] Prognostic significance of RB1-inducible coiled-coil 1 in salivary gland cancers (2012)
  • Author(s): Tameno H, Chano T, Ikebuchi K, Ochi Y, Arai A, Kishimoto M, Shimada T, Hisa Y, Okabe H.
  • Journal Title: Head Neck Volume: 34(5) Pages: 674-680
  • Peer Reviewed
• [Journal Article] Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway (2012)
  • Author(s): Tambe Y, Okuyama N, Nakagawa T, Muramoto A, Hasebe M, Chano T, Inoue H.
  • Journal Title: Cancer Lett Volume: 314(1) Pages: 82-91
  • Peer Reviewed
• [Journal Article] 診療における新規マーカーの探索と適用 (2012)
  • Author(s): 茶野徳宏
  • Journal Title: 臨床病理 Volume: 60(2) Pages: 167-173
  • NAID: 10030463258
• [Journal Article] Hyperbranched Polyglycerol-Grafted Superparamagnetic Iron Oxide Nanoparticles : Synthesis, Characterization, Functionalization, Size Separation, Magnetic Properties, and Biological Applications (2012)
  • Author(s): Zhao L, Chano T, Morikawa S, Saito Y, Shiino A, Shimizu S, Maeda T, Irie T, Aonuma S, Okabe H, Kimura T, Inubushi T, Komatsu N.
  • Journal Title: Adv Funct Mater Volume: 22(24) Pages: 5107-5117
  • Peer Reviewed
• [Journal Article] Hyperbranched Polyglycerol-Grafted Superparamagnetic Iron Oxide Nanoparticles: Synthesis, Characterization, Functionalization, Size Separation, Magnetic Properties, and Biological Applications. (2012)
  • Author(s): Li Zao
  • Journal Title: Adv Funct Mater Volume: 22 Issue: 24 Pages: 5107-5117
  • DOI: 10.1002/adfm.201201060
  • Peer Reviewed