• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

3D nano-lattices substrate for human pluripotent stem cells culture

Research Project

Project/Area Number 24651136
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Nanomaterials/Nanobioscience
Research InstitutionKyoto University

Principal Investigator

CHEN Yong  京都大学, 物質-細胞統合システム拠点, 教授 (70512458)

Co-Investigator(Kenkyū-buntansha) LI Liu  京都大学, 物質-細胞統合システム拠点, 助教 (50380093)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords3次元 / スカフォード / ヒト多能性幹細胞 / フィーダーフリ / 3次元
Research Abstract

Human pluripotent stem cells (hPSCs) are useful resources fortissue engineering, drug screening, and regenerative medicine. Cellular microenvironmental cues play critical roles in regulating hPSCs functions, but it is challenging to control them with synthetic components. In this project, we focus to develop a 3D nano-lattices scaffold for maintaining pluripotent stem cell culture based on micro-engineering tools and techniques. hPSCs on 3D nano-lattics scaffold showed a growth rate and they retained their pluripotency.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (1 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Nanofibrous gelatin substrates for long-term expansion of human pluripotent stem cells2014

    • Author(s)
      Li Liu, Momoko Yoshioka, Minako Nakajima, Arata Ogasawara, Jun Liu, Kouichi Hasegawa, Sisi Li, Jianli Zou, Norio Nakatsuji, Ken-ichiro Kamei, Yong Chen
    • Journal Title

      Biomaterial

      Volume: 35 Pages: 6259-6267

    • Related Report
      2013 Final Research Report
  • [Journal Article] Nanofibrous gelatin substrates for long-term expansion of human pluripotent stem cells2014

    • Author(s)
      Li Liu, Momoko Yoshioka, Minako Nakajima, Arata Ogasawara, Jun Liu, Kouichi Hasegawa, Sisi Li, Jianli Zou, Norio Nakatsuji, Ken-ichiro Kamei*, Yong Chen*
    • Journal Title

      Biomaterial

      Volume: in press Issue: 24 Pages: 6259-6267

    • DOI

      10.1016/j.biomaterials.2014.04.024

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of gelatin nanopatterns for cell culture studies2013

    • Author(s)
      S. S. Li, J. Shi, L. Liu, J.J. Li, L. M. Jiang, C. X. Luo, K. Kamei, Y. Chen
    • Journal Title

      Microelectron. Eng

      Volume: 110 Pages: 70-74

    • Related Report
      2013 Final Research Report
  • [Journal Article] Influence of patterned topographic features on the formation of cardiac cell clusters and their rhythmic activities2013

    • Author(s)
      L. Wang, L. Liu, N. Magome, K. Agladzea, Y. Chen
    • Journal Title

      Biofabrication

      Volume: 5(3)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Fabrication of gelatin nanopatterns for cell culture studies2013

    • Author(s)
      Sisi Li
    • Journal Title

      Microelectron. Eng.

      Volume: in press Pages: 70-74

    • DOI

      10.1016/j.mee.2013.01.053

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Combinatorial screening of gelatin nanofibers as cellular scaffolds to expand hPSCs for long-term period2013

    • Author(s)
      Li Liu, Ken-ichiro Kamei, Yong Chen
    • Organizer
      11th International Society for Stem Cell Research (ISSCR) Annual Meeting
    • Place of Presentation
      Boston (USA)
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.chen.icems.kyoto-u.ac.jp

    • Related Report
      2013 Final Research Report
  • [Remarks] Chen Group, iCeMS, Kyoto University

    • URL

      http://www.chen.icems.kyoto-u.ac.jp/

    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] ファイバー・オン・ファイバーを用いた多能性幹細胞の3次元培養方法及びそのための基材2013

    • Inventor(s)
      Ken-ichiro Kamei, Norio Nakatsuji, Li Liu, Yong Chen
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Number
      2013-117242
    • Filing Date
      2013-06-03
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 多能性幹細胞の培養方法及びそのための基材2012

    • Inventor(s)
      Li Liu, Ken-ichiro Kamei, Yong Chen
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Number
      2012-127580
    • Filing Date
      2012-06-04
    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi