Gold Micro-patterns for Surface-assisted Laser Desorption / Ionization Mass Spectrometry

• Project/Area Number: 24651146
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: Kyushu University
• Principal Investigator: NIIDOME Yasuro 九州大学, 工学(系)研究科(研究院), 准教授 (50264081)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 金ナノロッド / マイクロコンタクトプリンティング / ナノ機能材料 / SALDI-MS / ナノ材料 / ナノバイオ / 質量分析 / SALDI

Research Abstract

Gold micro/nano structures were prepared to be used for surface assisted Laser desorption/ionization mass spectrometry (SALDI-MS). We succeeded in preparing sub-micron-scale patterns of gold on an ITO plate using a micro-contact printing method; however, the sub-micron-patterns did not show efficient SALDI efficiencies. Gold nanoparticles (nanorods) were deposited on a plate to obtain aggregates up-to sub-micron scales, and then the SALDI efficiencies of those were evaluated. The best nanostructures for the SALDI processes were found to be small aggregates which contained less than 10 nanorods.

Research Products

• [Journal Article] Imaging Mass Spectrometry of Intravenously Injected Gold Nanorods in Mice (2014)
  • Author(s): Masanori Fujii, Naotoshi Nakashima, Takuro Niidome, and Yasuro Niidome
  • Journal Title: Chemistry Letters Volume: 43 Issue: 1 Pages: 131-133
  • DOI: 10.1246/cl.130864
  • NAID: 130004427094
  • Peer Reviewed
• [Journal Article] Spontaneous Temperature Control Using Reversible Spectroscopic Responses of PNIPAM-coated Gold Nanorods (2013)
  • Author(s): Kohei Shimoda, Tsuyohiko Fujigaya, Naotoshi Nakashima, and Yasuro Niidome
  • Journal Title: Chemistry Letters Volume: Vol.42, No.10 Issue: 10 Pages: 1247-1249
  • DOI: 10.1246/cl.130457
  • NAID: 10031201326
  • Peer Reviewed
• [Journal Article] Electrochemical Oxidation of Silver Shells on Gold Nanorods in Potassium Chloride and Phosphate Buffer Solutions (2013)
  • Author(s): Yuki Hamasaki, Naotoshi Nakashima, and Yasuro Niidome
  • Journal Title: Chemistry Letters Volume: Vol.42, No.9 Issue: 9 Pages: 1093-1095
  • DOI: 10.1246/cl.130350
  • NAID: 10031194353
  • Peer Reviewed
• [Presentation] Aggregates of metal nanoparticles for efficient laser-induced desorption/ionization processes (2013)
  • Author(s): Masanori Fujii、Naotoshi Nakashima、Yasuro Niidome
  • Organizer: The 4th Asian Symposium on Advanced Materials (ASAM-4)
  • Place of Presentation: National Taiwan University of Science and Technology
  • Year and Date: 2013-10-23
• [Presentation] Desorption of gold clusters from mouse tissue sections (2013)
  • Author(s): Masanori Fujii、Naotoshi Nakashima、Takuro Niidome、Yasuro Niidome
  • Organizer: The 4th Asian Symposium on Advanced Materials (ASAM-4)
  • Place of Presentation: National Taiwan University of Science and Technology
  • Year and Date: 2013-10-23
• [Presentation] 金属ナノ粒子の凝集状態がレーザー誘起脱離イオン化に与える影響 (2013)
  • Author(s): 藤井政徳、中嶋直敏、新留康郎
  • Organizer: 第64回コロイドおよび界面化学討論会
  • Place of Presentation: 名古屋工業大学,口頭講演
  • Year and Date: 2013-09-18
• [Presentation] 金属ナノ粒子の凝集状態が質量分析法の脱離イオン化に与える影響の検討 (2013)
  • Author(s): 藤井政徳、中嶋直敏、新留康郎
  • Organizer: 第50回化学関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場(ポスター)
  • Year and Date: 2013-07-06
• [Presentation] 異方性金属ナノ粒子の凝集状態とSALDI脱離イオン化の相関 (2013)
  • Author(s): 藤井政徳、中嶋直敏、新留康郎
  • Organizer: 第73回分析化学討論会
  • Place of Presentation: 北大函館キャンパス(口頭講演)
  • Year and Date: 2013-05-19
• [Presentation] 異方性金属ナノ粒子の凝集状態とSALDI脱離イオン化の相関 (2013)
  • Author(s): 藤井 政徳、中嶋 直敏、新留 康郎
  • Organizer: 第73回分析化学討論会
  • Place of Presentation: 北大函館キャンパス
• [Presentation] 金属ナノ粒子の凝集状態が質量分析法の脱離イオン化に与える影響の検討 (2013)
  • Author(s): 藤井 政徳、中嶋 直敏、新留 康郎
  • Organizer: 第50回化学関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場
• [Presentation] 金属ナノ粒子の凝集状態がレーザー誘起脱離イオン化に与える影響 (2013)
  • Author(s): 藤井 政徳、中嶋 直敏、新留 康郎
  • Organizer: 第６４回コロイドおよび界面化学討論会
  • Place of Presentation: 名古屋工業大学
• [Presentation] Surface-assisted Laser Desorption/Ionization Mass Spectrometry Using Gold Nanorods on ITO Plates (2012)
  • Author(s): Yasuro Niidome、Masanori Fujii、Naotoshi Nakashima
  • Organizer: MRS Fall Meeting 2012
  • Place of Presentation: Boston, USA(Poster)
  • Year and Date: 2012-11-27
• [Presentation] SALDI-MS of oligopeptide using gold nanorods on ITO plates (2012)
  • Author(s): Yasuro Niidome、Masanori Fujii、Yumi Taga、Naotoshi Nakashima
  • Organizer: The 19th International Mass Spectrometry Conference, (IMSC2012)
  • Place of Presentation: 京都国際会議場,口頭講演
  • Year and Date: 2012-09-17
• [Presentation] 表面支援レーザー脱離・イオン化質量分析法を用いた金ナノロッド表面のオリゴペプチドの検出 (2012)
  • Author(s): 藤井政徳、中嶋直敏、新留康郎
  • Organizer: 第49回化学関連支部合同九州大会
  • Place of Presentation: 北九州国際会議場(ポスター)
  • Year and Date: 2012-06-30
• [Presentation] Surface-Assisted Laser Desorption/Ionization Mass Spectrometry using Metal Nano-/Micro-Structures (2012)
  • Author(s): Yasuro Niidome、Masanori Fujii、Yumi Taga、Naotoshi Nakashima
  • Organizer: International Association of Colloid and Interface Scientists (IACIS 2012)
  • Place of Presentation: 仙台国際センター,口頭講演
  • Year and Date: 2012-05-13
• [Presentation] Surface-Assisted Laser Desorption/Ionization Mass Spectrometry using Metal Nano-/Micro-Structures (2012)
  • Author(s): Yasuro Niidome、Masanori Fujii、Yumi Taga、Naotoshi Nakashima
  • Organizer: IACIS 2012 (International Association of Colloid and Interface Scientists)
  • Place of Presentation: 仙台国際センター
• [Presentation] Detection of oligopeptide in surface assisted laser desorption/ionization time-of-flight mass spectrometry using gold nanorods (2012)
  • Author(s): Masanori Fujii、Yuki Nakamura、Naotoshi Nakashima、Yasuro Niidome
  • Organizer: IACIS 2012 (International Association of Colloid and Interface Scientists)
  • Place of Presentation: 仙台国際センター
• [Presentation] Detection of oligopeptide on gold nanorods using surface assisted laser desorption ionization time-of-flight mass spectrometry (2012)
  • Author(s): Masanori Fujii、Naotoshi Nakashima、Yasuro Niidome
  • Organizer: Gold 2012
  • Place of Presentation: 京王プラザホテル
• [Presentation] SALDI-MS of oligopeptide using gold nanorods on ITO plates (2012)
  • Author(s): Masanori Fujii、Naotoshi Nakashima、Yasuro Niidome
  • Organizer: IMSC2012 (The 19th International Mass Spectrometry Conference)
  • Place of Presentation: 京都国際会議場
• [Presentation] Surface-assisted Laser Desorption/Ionization Mass Spectrometry Using Gold Nanorods on ITO Plates (2012)
  • Author(s): Yasuro Niidome、Masanori Fujii、Naotoshi Nakashima
  • Organizer: MRS Fall Meeting
  • Place of Presentation: Boston, USA
• [Patent(Industrial Property Rights)] ナノ粒子脱離イオンプローブ質量分析 (2013)
  • Inventor(s): 新留 康郎
  • Industrial Property Rights Holder: 新留 康郎
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-126186
  • Filing Date: 2013-06-15
  • Overseas
• [Patent(Industrial Property Rights)] ナノ粒子脱離イオンプローブ質量分析 (2013)
  • Inventor(s): 新留康郎
  • Industrial Property Rights Holder: 新留康郎
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-126186
  • Filing Date: 2013-06-15