Development of an organ on a chip that mimics the ocular fundus
| Project/Area Number |
24651156
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Microdevices/Nanodevices
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| Research Institution | Tohoku University |
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Principal Investigator |
KAJI Hirokazu 東北大学, 工学(系)研究科(研究院), 准教授 (70431525)
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| Co-Investigator(Kenkyū-buntansha) |
ABE Toshiaki 東北大学, 大学院医学系研究科, 教授 (90191858)
NAGAI Nobuhiro 東北大学, 大学院医学系研究科, 教授 (30400039)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | システムオンチップ / 生体材料 / マイクロ・ナノデバイス / 細胞・組織 |
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| Research Abstract |
Developing new three-dimensional (3D) in vitro cell culture models closely mimicking human tissues and organs (referred to as "organ on a chip") has recently attracted great attention for disease modeling and drug discovery. In particular, there have been many attempts to mimic the digestive and respiratory systems such as the lung, liver and intestine. To date, however, there are few reported on on-chip culture models of sensory organs such as the eye. Thus, this research aims to develop a cell-based retinal model within a microfluidic device and to examine cellular responses to controlled environments. The characterization of neural supporting cells including retinal pigment epithelial cells cultured in the device was performed and found to exhibit properties found in native tissues. Application of stimuli that induce pathological changes in cultured cells would extend the system to a disease model for new therapy and drug discovery.
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Report
(3 results)
Research Products
(42 results)
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[Journal Article] A Platform for Controlled Dual-Drug Delivery to the Retina : Protective Effects against Light-Induced Retinal Damage in Rats2014
Author(s)
N Nagai, H Kaji, H Onami, Y Katsukura, Y Ishikawa, ZK Nezhad, K Sampei, S Iwata, S Ito, M Nishizawa, T Nakazawa, N Osumi, Y Mashima, T Abe
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Journal Title
Advanced Healthcare Materials
Volume: in press
Issue: 10
Pages: 680-687
DOI
Related Report
Peer Reviewed / Open Access
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[Book] MRS Symposium Proceesings Volume 1415, MEMS, BioMEMS andBioelectronics – Materials and Devices2012
Author(s)
Tim Albrecht, Maarten P. de Boer, Frank W. DelRio, Mehmet R. Dokmeci, Cristoph Eberl, Junji Fukuda, Hirokazu Kaji, Chris Keimel, Ali Khademhosseini
Total Pages
221
Publisher
Cambridge University Press
Related Report
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