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Spatio-temporal dynamic self-assembly of microhydrogels based on nonequilibrium

Research Project

Project/Area Number 24651159
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Microdevices/Nanodevices
Research InstitutionTokyo Institute of Technology

Principal Investigator

TAKINOUE Masahiro  東京工業大学, 総合理工学研究科(研究院), 講師 (20511249)

Co-Investigator(Kenkyū-buntansha) ONOE Hiroaki  東京大学, 生産技術研究所, 助教 (30548681)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords自己組織化 / 自律システム / マイクロマシン / マイクロ流体 / 生物物理 / 分子ロボット / DNAコンピュータ / マイクロ・ナノデバイス
Research Abstract

Self-assembled systems usually use a process of transition to an equilibrium stable state. In this case, only stable and homogeneous structures such as crystal structures can be constructed in a controlled manner. On the other hand, by this mechanism, complex and autonomous systems such as living systems cannot be constructed. In this study, we contributed to the development of a novel method to build up microstructures based on self-organization as dynamic self-assembly like living systems. In this method, nanometer-sized molecular reactions and micro/millimeter-sized structures are controlled under nonequilibrium condition.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (46 results)

All 2014 2013 2012 Other

All Journal Article (13 results) (of which Peer Reviewed: 6 results) Presentation (30 results) (of which Invited: 11 results) Remarks (3 results)

  • [Journal Article] マランゴニ流と拡散流を利用した複雑形状マイクロハイドロゲル粒子高速生成システムの開発2014

    • Author(s)
      早川雅之,尾上弘晃,永井健,瀧ノ上正浩
    • Journal Title

      化学とマイクロ・ナノシステム

      Volume: vol. 13, no. 1 Pages: 29-30

    • Related Report
      2013 Final Research Report
  • [Journal Article] マランゴニ流と拡散流を利用した複雑形状マイクロハイドロゲル粒子高速生成システムの開発2014

    • Author(s)
      早川雅之,尾上弘晃,永井健,瀧ノ上正浩
    • Journal Title

      化学とマイクロ・ナノシステム

      Volume: vol. 13,no.1 Pages: 29-30

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 異方性をもつ複雑形状マイクロハイドロゲル粒子作製システムの開発2013

    • Author(s)
      早川雅之,尾上弘晃,永井健,瀧ノ上正浩
    • Journal Title

      電気学会研究会資料(バイオ・マイクロシステム研究会)

      Volume: No.BMS-13-043 Pages: 41-44

    • Related Report
      2013 Final Research Report
  • [Journal Article] Rapid formation of anisotropic non-spherical hydrogel microparticles with complex structures using a tabletop centrifuge-based microfluidic device2013

    • Author(s)
      Masayuki Hayakawa, Hiroaki Onoe, Ken H. Nagai, Masahiro Takinoue
    • Journal Title

      Proceedings of micro

      Volume: TAS2013 Pages: 630-632

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Centrifuge-based single cell encapsulation in hydrogel microbeads from ultra low volume of samples2013

    • Author(s)
      Kiichi Inamori, Hiroaki Onoe, Masahiro Takinoue, Shoji Takeuchi
    • Journal Title

      Proceedings of micro

      Volume: TAS2013 Pages: 314-316

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid formation of anisotropic non-spherical hydrogel microparticles with complex structures using a tabletop centrifuge-based microfluidic device2013

    • Author(s)
      Masayuki Hayakawa, Hiroaki Onoe, Ken H. Nagai, Masahiro Takinoue
    • Journal Title

      The 17th International Conference on Miniturized Systems for Chemistry and Life Sciences (microTAS2013)

      Volume: 1 Pages: 630-632

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Centrifuge-based single cell encapsulation in hydrogel microbeads from ultra low volume of samples2013

    • Author(s)
      Kiichi Inamori, Hiroaki Onoe, Masahiro Takinoue, Shoji Takeuchi
    • Journal Title

      The 17th International Conference on Miniturized Systems for Chemistry and Life Sciences (microTAS2013)

      Volume: 1 Pages: 314-316

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 異方性をもつ複雑形状マイクロハイドロゲル粒子作製システムの開発2013

    • Author(s)
      早川雅之,尾上弘晃,永井健,瀧ノ上正浩
    • Journal Title

      電気学会研究会資料(バイオ・マイクロシステム研究会)

      Volume: No.BMS-13-043 Pages: 41-44

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Instantaneous Solidification of a Centrifuge-driven Capillary Jet with Controlled Hydrodynamic Instability in a Centrifuge-based Droplet Shooting Device through Observational Analysis2012

    • Author(s)
      Kazuki Maeda, Hiroaki Onoe, Masahiro Takinoue, Shoji Takeuchi
    • Journal Title

      Proceedings of micro

      Volume: TAS2012 Pages: 878-880

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] コラム : 複雑な非対称性をもつマイクロ粒子2012

    • Author(s)
      瀧ノ上正浩
    • Journal Title

      パリティ(丸善)

      Volume: 5月号 Pages: 20-20

    • Related Report
      2013 Final Research Report
  • [Journal Article] 閉じ込め系におかれた複雑流体の可能性2012

    • Author(s)
      瀧ノ上正浩(訳), Amy Q. Shen, Perry Cheung(著)
    • Journal Title

      パリティ(丸善)

      Volume: 5月号 Pages: 12-20

    • NAID

      40019231377

    • Related Report
      2013 Final Research Report
  • [Journal Article] Instantaneous Solidification of a Centrifuge-driven Capillary Jet with Controlled Hydrodynamic Instability in a Centrifuge-based Droplet Shooting Device through Observational Analysis2012

    • Author(s)
      Kazuki Maeda, Hiroaki Onoe, Masahiro Takinoue, Shoji Takeuchi
    • Journal Title

      The 16th International Conference on Miniturized Systems for Chemistry and Life Sciences (microTAS2012)

      Volume: 1 Pages: 878-880

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] コラム:複雑な非対称性をもつマイクロ粒子2012

    • Author(s)
      瀧ノ上正浩
    • Journal Title

      パリティ(丸善)

      Volume: Vol.27 No.05 Pages: 20-20

    • Related Report
      2012 Research-status Report
  • [Presentation] マランゴニ流と拡散流による微小液滴の変形原理の解明と複雑形状粒子の構築2014

    • Author(s)
      早川雅之,尾上弘晃,永井健,瀧ノ上正浩
    • Organizer
      日本物理学会第69回年次大会
    • Place of Presentation
      東海大学湘南キャンパス,神奈川(ポスター発表, No. 1P14)
    • Related Report
      2013 Final Research Report
  • [Presentation] マランゴニ流と拡散流による微小液滴の変形原理の解明と複雑形状粒子の構築2014

    • Author(s)
      早川雅之, 尾上弘晃, 永井健, 瀧ノ上正浩
    • Organizer
      日本物理学会第69回年次大会
    • Place of Presentation
      東海大学湘南キャンパス(神奈川県平塚市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Microfluidic techno- logies toward the construction of non- equilibrium artificial cells and molecular robots2013

    • Author(s)
      Masahiro Takinoue
    • Organizer
      Prof. Utkan Demirci Lab. Seminar (MIT-Harvard medical school)
    • Place of Presentation
      Boston, USA
    • Year and Date
      2013-11-04
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] マイクロ非平衡場の制御による動的な細胞サイズ分子ロボットの創製2013

    • Author(s)
      瀧ノ上正浩
    • Organizer
      平成25年度・東工大挑戦的研究賞授賞式
    • Place of Presentation
      東京工業大学大岡山キャンパス,東京
    • Year and Date
      2013-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 異方性をもつ複雑形状マイクロハイドロゲル粒子作製システムの開発2013

    • Author(s)
      早川雅之,尾上弘晃,永井健,瀧ノ上正浩
    • Organizer
      バイオ・マイクロシステム研究会, No.BMS-13-043
    • Place of Presentation
      東京大学生産技術研究所,東京
    • Year and Date
      2013-10-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Rapid formation of anisotropic non-spherical hydrogel microparticles with complex structures using a tabletop centrifuge-based microfluidic device2013

    • Author(s)
      Masayuki Hayakawa, Hiroaki Onoe, Ken H. Nagai, and Masahiro Takinoue
    • Organizer
      The 17th International Conference on Miniturized Systems for Chemistry and Life Sciences (microTAS2013)
    • Place of Presentation
      Freiburg, Germany(oral)
    • Related Report
      2013 Final Research Report
  • [Presentation] Centrifuge-based single cell encapsulation in hydrogel microbeads from ultra low volume of samples2013

    • Author(s)
      Kiichi Inamori, Hiroaki Onoe, Masahiro Takinoue, Shoji Takeuchi
    • Organizer
      The 17th International Conference on Miniturized Systems for Chemistry and Life Sciences (microTAS2013)
    • Place of Presentation
      Freiburg, Germany(poster M.086d)
    • Related Report
      2013 Final Research Report
  • [Presentation] マイクロサイズの非平衡場の制御による動的人工細胞の構築と異方性複雑形状粒子の作製2013

    • Author(s)
      瀧ノ上正浩
    • Organizer
      第7回自己組織化討論会
    • Place of Presentation
      晴海グランドホテル,東京
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] マランゴニ流と拡散流を利用した複雑形状マイクロハイドロゲル粒子高速生成システムの開発2013

    • Author(s)
      早川雅之,尾上弘晃,永井健,瀧ノ上正浩
    • Organizer
      化学とマイクロ・ナノシステム学会第28回研究会
    • Place of Presentation
      イーグレひめじ,姫路(ポスター発表, No. 1P14)
    • Related Report
      2013 Final Research Report
  • [Presentation] 遠心力を利用した複雑形状マイクロハイドロゲル粒子の高速生成(Centrifuge-based rapid synthesis of complex-shaped microhydrogel particles)2013

    • Author(s)
      Masayuki Hayakawa, Hiroaki Onoe, Ken H. Nagai, Masahiro Takinoue
    • Organizer
      第51回日本生物物理学会
    • Place of Presentation
      京都(ポスター発表, No. 3P312)
    • Related Report
      2013 Final Research Report
  • [Presentation] Nano/micro- techno- logies for the Construction of Non- equilibrium Artificial Cell Models2013

    • Author(s)
      Masahiro Takinoue
    • Organizer
      French- Japanese Seminar on "Bioinspired Methods and Applications"
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Rapid formation of anisotropic non-spherical hydrogel microparticles with complex structures using a tabletop centrifuge-based microfluidic device2013

    • Author(s)
      Masayuki Hayakawa, Hiroaki Onoe, Ken H. Nagai, Masahiro Takinoue
    • Organizer
      The 17th International Conference on Miniturized Systems for Chemistry and Life Sciences (microTAS2013)
    • Place of Presentation
      Messe Freiburg (Germany, Freiburg)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Centrifuge-based single cell encapsulation in hydrogel microbeads from ultra low volume of samples2013

    • Author(s)
      Kiichi Inamori, Hiroaki Onoe, Masahiro Takinoue, Shoji Takeuchi
    • Organizer
      The 17th International Conference on Miniturized Systems for Chemistry and Life Sciences (microTAS2013)
    • Place of Presentation
      Messe Freiburg(Germany, Freiburg)
    • Related Report
      2013 Annual Research Report
  • [Presentation] マイクロサイズの非平衡場の制御による動的人工細胞の構築と異方性複雑形状粒子の作製2013

    • Author(s)
      瀧ノ上正浩
    • Organizer
      第7回自己組織化討論会
    • Place of Presentation
      晴海グランドホテル(東京都中央区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] マランゴニ流と拡散流による微小液滴の変形原理の解明と複雑形状粒子高速生成システムの開発2013

    • Author(s)
      早川雅之, 尾上弘晃, 永井健, 瀧ノ上正浩
    • Organizer
      化学とマイク ロ・ナノシステム学会 第28回研究会
    • Place of Presentation
      イーグレ姫路(兵庫県姫路市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 遠心力を利用した複雑形状マイクロハイドロゲル粒子の高速生成(Centrifuge-based rapid synthesis of complex-shaped microhydrogel particles)2013

    • Author(s)
      Masayuki Hayakawa, Hiroaki Onoe, Ken H. Nagai, Masahiro Takinoue,
    • Organizer
      第51回日本生物物理学会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Nano/micro-technologies for the Construction of Non- equilibrium Artificial Cell Models2013

    • Author(s)
      Masahiro Takinoue
    • Organizer
      French-Japanese Seminar on “Bioinspired Methods and Applications
    • Place of Presentation
      フランス大使館・東京大学生産技術研究所
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 分子ロボットの感覚2012

    • Author(s)
      瀧ノ上正浩
    • Organizer
      計測自動制御学会システム・情報部門学術講演会2012
    • Place of Presentation
      うぃるあいち,名古屋
    • Year and Date
      2012-11-23
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 自己駆動粒子への応用を目指した非球形マイクロゲルの作製法2012

    • Author(s)
      早川雅之,尾上弘晃,永井健,瀧ノ上正浩
    • Organizer
      「細胞を創る」研究会5.0
    • Place of Presentation
      東京工業大学すずかけ台キャンパス,横浜(ポスター, No. P-45)
    • Year and Date
      2012-11-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 分子ロボットへの生物物理学的アプローチ2012

    • Author(s)
      瀧ノ上正浩
    • Organizer
      人工知能学会合同研究会
    • Place of Presentation
      慶応義塾大学日吉キャンパス,横浜
    • Year and Date
      2012-11-15
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Instantaneous Solidification of a Centrifuge-driven Capillary Jet with Controlled Hydrodynamic Instability in a Centrifuge-based Droplet Shooting Device through Observational Analysis2012

    • Author(s)
      Kazuki Maeda, Hiroaki Onoe, Masahiro Takinoue, Shoji Takeuchi
    • Organizer
      The 16th International Conference on Miniturized Systems for Chemistry and Life Sciences (microTAS2012)
    • Place of Presentation
      Okinawa, Japan(poster No. T.1.6)
    • Related Report
      2013 Final Research Report
  • [Presentation] 高重力を利用した非球形構造を持つマイクロハイドロゲル粒子の作製法2012

    • Author(s)
      Masayuki Hayakawa, Hiroaki Onoe, Ken H. Nagai, Masahiro Takinoue
    • Organizer
      第50回日本生物物理学会
    • Place of Presentation
      名古屋大学東山キャンパス,名古屋(ポスター発表, No. 1PT224)
    • Related Report
      2013 Final Research Report
  • [Presentation] 分子ロボットの感覚2012

    • Author(s)
      瀧ノ上正浩
    • Organizer
      計測自動制御学会 システム・情報部門学術講演会2012
    • Place of Presentation
      ウィルあいち
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 分子ロボットへの生物物理学的アプローチ2012

    • Author(s)
      瀧ノ上正浩
    • Organizer
      人工知能学会合同研究会
    • Place of Presentation
      慶応義塾大学日吉キャンパス
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Instantaneous Solidification of a Centrifuge-driven Capillary Jet with Controlled Hydrodynamic Instability in a Centrifuge-based Droplet Shooting Device through Observational Analysis2012

    • Author(s)
      Kazuki Maeda, Hiroaki Onoe, Masahiro Takinoue, Shoji Takeuchi
    • Organizer
      The 16th International Conference on Miniturized Systems for Chemistry and Life Sciences (microTAS2012)
    • Place of Presentation
      沖縄コンベンションセンター
    • Related Report
      2012 Research-status Report
  • [Presentation] 自己駆動粒子への応用を目指した非球形マイクロゲル粒子の作製法2012

    • Author(s)
      早川雅之, 尾上弘晃, 永井健, 瀧ノ上正浩
    • Organizer
      「細胞を創る」研究会5.0
    • Place of Presentation
      東京工業大学すずかけ台キャンパス
    • Related Report
      2012 Research-status Report
  • [Presentation] 高重力を利用した非球形構造を持つマイクロハイドロゲル粒子の作製法(High-gravity-based synthesizing method for hydrogel microparticles with non-spherical structures)2012

    • Author(s)
      Masayuki Hayakawa, Hiroaki Onoe, Ken H. Nagai, Masahiro Takinoue
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Related Report
      2012 Research-status Report
  • [Presentation] Microfluidic technologies toward the construction of nonequilibrium artificial cells and molecular robots

    • Author(s)
      Masahiro Takinoue
    • Organizer
      Prof. Utkan Demirci Lab. Seminar
    • Place of Presentation
      MIT-Harvard medical school, Boston, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] マイクロ非平衡場の制御による動的な細胞サイズ分子ロボットの創製

    • Author(s)
      瀧ノ上正浩
    • Organizer
      平成25年度東工大挑戦的研究賞授賞式
    • Place of Presentation
      東京工業大学(東京都目黒区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 異方性をもつ複雑形状マイクロハイドロゲル粒子作製システムの開発

    • Author(s)
      早川雅之, 尾上弘晃, 永井健, 瀧ノ上正浩
    • Organizer
      バイオ・マイクロシステム研究会
    • Place of Presentation
      東京大学生産技術研究所(東京都目黒区)
    • Related Report
      2013 Annual Research Report
  • [Remarks] 瀧ノ上研究室ホームページ

    • URL

      http://www.lifephys.dis.titech.ac.jp

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京工業大学 瀧ノ上研究室 ホームページ

    • URL

      http://www.lifephys.dis.titech.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 瀧ノ上正浩研究室ホームページ

    • URL

      http://www.lifephys.dis.titech.ac.jp/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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