Development of natural products microarray for search of neural stem cell modulators
| Project/Area Number |
24651238
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Chiba University |
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Principal Investigator |
ARAI Midori 千葉大学, 薬学研究科(研究院), 准教授 (40373261)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 天然物 / アレイ / ビタミンＤ３ / 神経幹細胞 / タンパク質 |
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| Research Abstract |
Natural product extract microarray would be greatly helpful for search bioactive compounds by incubation with target proteins. Reported method needed the structural change in each natural products. In this study, the material for microarray, method for making array, incubation with target protein etc. were investigated. Poly-ether sulfone (PES) was found to be good membrane for thin-layer chromatography of extract. Vitamin D receptor and its positive control 1a, 25 (OH)2 VD3 were used for establishment of the method.
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Report
(3 results)
Research Products
(34 results)
