| Project/Area Number |
24651248
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | Nagoya University (2014)
Institute of Physical and Chemical Research (2012-2013) |
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Principal Investigator |
NAKAGAWA Yu 名古屋大学, 生命農学研究科, 准教授 (90452284)
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| Co-Investigator(Renkei-kenkyūsha) |
IRIE Kazuhiro 京都大学, 大学院農学研究科, 教授 (00168535)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 生理活性 / 蛋白質 / 糖 / 有機合成 / タンパク質 |
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| Outline of Final Research Achievements |
On the basis of the fact that L-rhamnose is equivalent to 6-deoxy-L-mannose, this study tried to synthesize an enantiomer of rhamnose-binding domains of catfish lectin SAL as a novel mannose receptor. In parallel, attempts were also made to develop a galactose receptor based on an enantiomer of PhoSL, a mushroom lectin for L-fucose, which is equivalent to 6-deoxy-L-galactose. This study aimed to propose a strategy for designing enantiomers of proteins as bioactive molecules having functions different from those of parent proteins.
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