Development of a chemical biosensing technology for exploring bioactive compounds
| Project/Area Number |
24651250
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
WADA Akira 独立行政法人理化学研究所, 長田抗生物質研究室, 専任研究員 (90443051)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | バイオセンシング / 生物活性化合物 / 生物活性小分子 / 標的タンパク質 |
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| Outline of Final Research Achievements |
In this research, to develop a chemical biosensing technology that enables ultrasensitive detection of bioactive compound-protein interactions, fluorescent molecule-displayed probes with specific affinity for peptide tags were originally synthesized. In addition, the utility and potential of a new principle for detecting specific interactions between the fluorescent probes and cell-free synthesized proteins having the peptide tags were evaluated.
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Report
(4 results)
Research Products
(6 results)
