The Influence of Gene and Environmental Interactions on Cognitive and Emotional Status in Older Adults

• Project/Area Number: 24653194
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Clinical psychology
• Research Institution: Osaka University
• Principal Investigator: GONDO Yasuyuki 大阪大学, 人間科学研究科, 准教授 (40250196)
• Co-Investigator(Kenkyū-buntansha): KAMIDE Kei 大阪大学, 大学院医学(系)研究科(研究院), 教授 (80393239)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 環境 / 遺伝 / 認知機能 / 感情 / 高齢期

Research Abstract

This study was designed to evaluate the influence of gene-environment interactions on the cognitive function or emotional state in older adults. Parallel studies for the development of measurement systems of environmental condition and gene typing were performed.
Original methods to evaluate school achievement in childhood, job experience (complexity and stress) in midlife were developed. SNP typing for 6 candidate genes were also performed. A series of analyses to test the interaction of job complexity in midlife and each gene polymorphism on cognition were performed. Although the results showed a possibility of gene and environmental interaction in some genes (e.g., Klotho), the statistical power was too small to fully support this hypothesis. These results indicate that a more deliberate choice of control variables such as the medical condition is needed to clarify gene-environment interactions in a complex human life context.

Research Products

• [Journal Article] 学際研究による老年社会科学からの健康長寿へのアプローチ (2014)
  • Author(s): 権藤恭之
  • Journal Title: 日本老年医学会雑誌 Volume: 51(1) Pages: 35-38
• [Journal Article] Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity (2013)
  • Author(s): Benigni A, Orisio S, Noris M, Iatropoulos P, Castaldi D, Kamide K, Rakugi H, Arai Y, Todeschini M, Ogliari G, Imai E, Gondo Y, Hirose N, Mari D, Remuzzi G
  • Journal Title: Age Volume: 35(3) Pages: 993-1005
  • Peer Reviewed
• [Journal Article] パーソナリティと長寿に関する研究動向 (2013)
  • Author(s): 権藤恭之
  • Journal Title: 老年社会科学 Volume: 35(3) Pages: 374-383
  • NAID: 40019840905
• [Journal Article] Sources of variation on the mini-mental state examination in a population-based sample of centenarians (2013)
  • Author(s): Dai, T., Davey, A., Woodard, J. L., Miller, L. S., Gondo, Y., Kim, S.-H., & Poon, L. W
  • Journal Title: Journal of the American Geriatrics Society Volume: 61(8) Pages: 1369-76
• [Journal Article] Profiles of cognitive functioning in a population-based sample of centenarians using factor mixture analysis (2013)
  • Author(s): Davey, A., Dai, T., Woodard, J. L., Miller, L. S., Gondo, Y., Johnson, M. A., Poon, L. W
  • Journal Title: Experimental Aging Research Volume: 39(2) Pages: 125-44
• [Journal Article] メモの利用が高齢者の展望的記憶に及ぼす補償効果の検証と効果的なメモの検討 (2013)
  • Author(s): 山根裕樹,権藤恭之,蓮花のぞみ,石岡良子
  • Journal Title: 応用老年学 Volume: 6(1) Pages: 50-58
  • NAID: 40019421809
• [Journal Article] Sources of variation on the mini-mental state examination in a population-based sample of centenarians. (2013)
  • Author(s): Dai T, Davey A, Woodard JL, Miller LS, Gondo Y, Kim SH, Poon LW.
  • Journal Title: J Am Geriatr Soc. Volume: 61 Pages: 1369-1376
  • DOI: 10.1111/jgs.12370
  • Peer Reviewed
• [Journal Article] Profiles of cognitive functioning in a population-based sample of centenarians using factor mixture analysis. (2013)
  • Author(s): Davey A, Dai T, Woodard JL, Miller LS, Gondo Y, Johnson MA, Hausman DB, Martin P, Green RC, Allen RH, Stabler SP, Poon LW; Georgia Centenarian.
  • Journal Title: Exp Aging Res. Volume: 39 Pages: 125-144
  • DOI: 10.1080/0361073x.2013.761869
  • Peer Reviewed
• [Journal Article] Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity. (2013)
  • Author(s): Benigni A, Orisio S, Noris M, Iatropoulos P, Castaldi D, Kamide K, Rakugi H, Arai Y, et al.
  • Journal Title: Age (Dordr). Volume: 35 Pages: 993-1005
  • Peer Reviewed
• [Journal Article] メモの利用が高齢者の展望的記憶に及ぼす補償効果の検証と効果的なメモの検討 (2013)
  • Author(s): 山根裕樹, 権藤恭之, 蓮花のぞみ, 石岡良子
  • Journal Title: 応用老年学 Volume: 6 Pages: 50-58
  • NAID: 40019421809
  • Peer Reviewed
• [Journal Article] Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B (2012)
  • Author(s): Congrains A, Kamide K, Oguro R, Yasuda O, Miyata K, Yamamoto E, Kawai T, Kusunoki H, Yamamoto H, Takeya Y, Yamamoto K, Onishi M, Sugimoto K, Katsuya T, Awata N, Ikebe K, Gondo Y, Oike Y, Ohishi M, Rakugi H
  • Journal Title: Atherosclerosis Volume: 220(2) Pages: 449-55
  • Peer Reviewed
• [Journal Article] Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B. (2012)
  • Author(s): Congrains, A.(共著)
  • Journal Title: Atherosclerosis Volume: 220 Pages: 449-455
  • DOI: 10.1016/j.atherosclerosis.2011.11.017
  • Peer Reviewed
• [Presentation] 前期,後期高齢者の認知機能と仕事の複雑性との関連―SONIC研究の結果より― (2013)
  • Author(s): 石岡良子,権藤恭之,増井幸恵,稲垣宏樹,小川まどか,中川威,立平起子,神出計,池邉一典,新井康通,高橋龍太郎
  • Organizer: 第55回老年社会科学大会
  • Place of Presentation: 大阪
  • Year and Date: 2013-06-06
• [Presentation] 高齢者の余暇活動と精神的健康の関連―SONIC研究における70歳調査結果より― (2013)
  • Author(s): 小園麻里菜,権藤恭之,小川まどか,石岡良子,増井幸恵,中川威,立平起子,神出計,池邉一典,新井康通,高橋龍太郎
  • Organizer: 第55回老年社会科学大会
  • Place of Presentation: 大阪
  • Year and Date: 2013-06-05
• [Presentation] Complexity of work and late-life cognitive function (2013)
  • Author(s): Ishioka Y, Gondo Y, Masui Y, Nakagawa T, Tatsuhira Y, Ogawa M, Ikebe K, Kamide K, Takahashi R, & Arai Y
  • Organizer: 20th International Association of Gerontology and Geriatrics World Congress of Gerontology and Geriatrics
  • Place of Presentation: Korea
  • Year and Date: 2013-01-25
• [Presentation] Does Type of Activities Matter? Age and Gender Differences in Leisure Activities Among Japanese Older Adults (2013)
  • Author(s): Ogawa M, Ishioka Y, Gondo Y, Kozono M, Masui Y, Nakagawa T, Tabuchi M , Tatsuhira Y, Ikebe K, Kamide K, Arai Y, Ishizaki T, & Takahashi R
  • Organizer: 20th International Association of Gerontology and Geriatrics World Congress of Gerontology and Geriatrics
  • Place of Presentation: Korea
• [Presentation] New successful aging model in the longevity society (2013)
  • Author(s): Gondo Y
  • Organizer: International Association of Gerontology and Geriatrics World Congress of Gerontology and Geriatrics
  • Place of Presentation: Korea
• [Presentation] Complexity of work and late-life cognitive function. (2013)
  • Author(s): Ishioka Y, Gondo Y, Masui Y, Nakagawa T, Tatsuhira Y, Ogawa M, Ikebe K, Kamide K, Takahashi R, & Arai Y.
  • Organizer: 20th International Association of Gerontology and Geriatrics World Congress of Gerontology and Geriatrics,
  • Place of Presentation: Soul, Korea
• [Presentation] Does Type of Activities Matter? Age and Gender Differences in Leisure Activities Among Japanese Older Adults. (2013)
  • Author(s): Ogawa M, Ishioka Y, Gondo Y, Kozono M, Masui Y, Nakagawa T, Tabuchi M , Tatsuhira Y, Ikebe K, Kamide K, Arai Y, Ishizaki T, & Takahashi R.
  • Organizer: 20th International Association of Gerontology and Geriatrics World Congress of Gerontology and Geriatrics,
  • Place of Presentation: Soul, Korea
• [Presentation] 井康通, 高橋龍太郎. 前期・後期高齢者の認知機能と仕事の複雑性との関連―SONIC研究の結果より―. (2013)
  • Author(s): 石岡良子, 権藤恭之, 増井幸恵, 稲垣宏樹, 小川まどか, 中川 威, 立平起子, 神出 計, 池邉一典, 新 井康通, 高橋龍太郎.
  • Organizer: 第55回老年社会科学大会,
  • Place of Presentation: 大阪
• [Presentation] 高齢者の余暇活動と精神的健康の関連―SONIC研究における70歳調査結果より―. (2013)
  • Author(s): 小園麻里菜, 権藤恭之, 小川まどか, 石岡良子, 増井幸恵, 中川 威, 立平起子, 神出 計, 池邉一典, 新井康通, 高橋龍太郎.
  • Organizer: 第55回老年社会科学大会,
  • Place of Presentation: 大阪
• [Presentation] New Successful aging model in the longevity society (2013)
  • Author(s): Gondo Y
  • Organizer: 20th International Association of Gerontology and Geriatrics World Congress of Gerontology and Geriatrics,
  • Place of Presentation: Soul, Korea
• [Book] A complete reference guide, Volume IV, Wellbeing in Later life (2014)
  • Author(s): Gondo Y, Arai Y, Hirose N WILEY
  • Total Pages: 411
  • Publisher: Wellbeing
• [Book] Dementia and Memory (2014)
  • Author(s): Gondo Y, Masui Y, Inagaki H Hirose N
  • Total Pages: 250
  • Publisher: Psychology Press
• [Book] Wellbeing: A Complete Reference Guide, Volume IV, Wellbeing in Later Life (2014)
  • Author(s): Gondo Y, Arai Y, and Hirose, N
  • Total Pages: 411
  • Publisher: WILEY
• [Book] Dementia and Memory (2014)
  • Author(s): Gondo Y, Masui Y, Inagaki H, and Hirose N
  • Total Pages: 250
  • Publisher: Psychology Press