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The Influence of Gene and Environmental Interactions on Cognitive and Emotional Status in Older Adults

Research Project

Project/Area Number 24653194
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Clinical psychology
Research InstitutionOsaka University

Principal Investigator

GONDO Yasuyuki  大阪大学, 人間科学研究科, 准教授 (40250196)

Co-Investigator(Kenkyū-buntansha) KAMIDE Kei  大阪大学, 大学院医学(系)研究科(研究院), 教授 (80393239)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords環境 / 遺伝 / 認知機能 / 感情 / 高齢期
Research Abstract

This study was designed to evaluate the influence of gene-environment interactions on the cognitive function or emotional state in older adults. Parallel studies for the development of measurement systems of environmental condition and gene typing were performed.
Original methods to evaluate school achievement in childhood, job experience (complexity and stress) in midlife were developed. SNP typing for 6 candidate genes were also performed. A series of analyses to test the interaction of job complexity in midlife and each gene polymorphism on cognition were performed. Although the results showed a possibility of gene and environmental interaction in some genes (e.g., Klotho), the statistical power was too small to fully support this hypothesis. These results indicate that a more deliberate choice of control variables such as the medical condition is needed to clarify gene-environment interactions in a complex human life context.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (26 results)

All 2014 2013 2012

All Journal Article (12 results) (of which Peer Reviewed: 7 results) Presentation (10 results) Book (4 results)

  • [Journal Article] 学際研究による老年社会科学からの健康長寿へのアプローチ2014

    • Author(s)
      権藤恭之
    • Journal Title

      日本老年医学会雑誌

      Volume: 51(1) Pages: 35-38

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity2013

    • Author(s)
      Benigni A, Orisio S, Noris M, Iatropoulos P, Castaldi D, Kamide K, Rakugi H, Arai Y, Todeschini M, Ogliari G, Imai E, Gondo Y, Hirose N, Mari D, Remuzzi G
    • Journal Title

      Age

      Volume: 35(3) Pages: 993-1005

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] パーソナリティと長寿に関する研究動向2013

    • Author(s)
      権藤恭之
    • Journal Title

      老年社会科学

      Volume: 35(3) Pages: 374-383

    • NAID

      40019840905

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Sources of variation on the mini-mental state examination in a population-based sample of centenarians2013

    • Author(s)
      Dai, T., Davey, A., Woodard, J. L., Miller, L. S., Gondo, Y., Kim, S.-H., & Poon, L. W
    • Journal Title

      Journal of the American Geriatrics Society

      Volume: 61(8) Pages: 1369-76

    • Related Report
      2013 Final Research Report
  • [Journal Article] Profiles of cognitive functioning in a population-based sample of centenarians using factor mixture analysis2013

    • Author(s)
      Davey, A., Dai, T., Woodard, J. L., Miller, L. S., Gondo, Y., Johnson, M. A., Poon, L. W
    • Journal Title

      Experimental Aging Research

      Volume: 39(2) Pages: 125-44

    • Related Report
      2013 Final Research Report
  • [Journal Article] メモの利用が高齢者の展望的記憶に及ぼす補償効果の検証と効果的なメモの検討2013

    • Author(s)
      山根裕樹,権藤恭之,蓮花のぞみ,石岡良子
    • Journal Title

      応用老年学

      Volume: 6(1) Pages: 50-58

    • NAID

      40019421809

    • Related Report
      2013 Final Research Report
  • [Journal Article] Sources of variation on the mini-mental state examination in a population-based sample of centenarians.2013

    • Author(s)
      Dai T, Davey A, Woodard JL, Miller LS, Gondo Y, Kim SH, Poon LW.
    • Journal Title

      J Am Geriatr Soc.

      Volume: 61 Issue: 8 Pages: 1369-1376

    • DOI

      10.1111/jgs.12370

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Profiles of cognitive functioning in a population-based sample of centenarians using factor mixture analysis.2013

    • Author(s)
      Davey A, Dai T, Woodard JL, Miller LS, Gondo Y, Johnson MA, Hausman DB, Martin P, Green RC, Allen RH, Stabler SP, Poon LW; Georgia Centenarian.
    • Journal Title

      Exp Aging Res.

      Volume: 39 Issue: 2 Pages: 125-144

    • DOI

      10.1080/0361073x.2013.761869

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity.2013

    • Author(s)
      Benigni A, Orisio S, Noris M, Iatropoulos P, Castaldi D, Kamide K, Rakugi H, Arai Y, et al.
    • Journal Title

      Age (Dordr).

      Volume: 35 Issue: 3 Pages: 993-1005

    • DOI

      10.1007/s11357-012-9408-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メモの利用が高齢者の展望的記憶に及ぼす補償効果の検証と効果的なメモの検討2013

    • Author(s)
      山根裕樹, 権藤恭之, 蓮花のぞみ, 石岡良子
    • Journal Title

      応用老年学

      Volume: 6 Pages: 50-58

    • NAID

      40019421809

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B2012

    • Author(s)
      Congrains A, Kamide K, Oguro R, Yasuda O, Miyata K, Yamamoto E, Kawai T, Kusunoki H, Yamamoto H, Takeya Y, Yamamoto K, Onishi M, Sugimoto K, Katsuya T, Awata N, Ikebe K, Gondo Y, Oike Y, Ohishi M, Rakugi H
    • Journal Title

      Atherosclerosis

      Volume: 220(2) Pages: 449-55

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variants at the 9p21 locus contribute to a atherosclerosis through modulation of ANRIL and CDKN2A/B2012

    • Author(s)
      Congrains, A.(共著)
    • Journal Title

      Atherosclerosis

      Volume: 220 Issue: 2 Pages: 449-455

    • DOI

      10.1016/j.atherosclerosis.2011.11.017

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 前期,後期高齢者の認知機能と仕事の複雑性との関連―SONIC研究の結果より―2013

    • Author(s)
      石岡良子,権藤恭之,増井幸恵,稲垣宏樹,小川まどか,中川威,立平起子,神出計,池邉一典,新井康通,高橋龍太郎
    • Organizer
      第55回老年社会科学大会
    • Place of Presentation
      大阪
    • Year and Date
      2013-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 高齢者の余暇活動と精神的健康の関連―SONIC研究における70歳調査結果より―2013

    • Author(s)
      小園麻里菜,権藤恭之,小川まどか,石岡良子,増井幸恵,中川威,立平起子,神出計,池邉一典,新井康通,高橋龍太郎
    • Organizer
      第55回老年社会科学大会
    • Place of Presentation
      大阪
    • Year and Date
      2013-06-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Complexity of work and late-life cognitive function2013

    • Author(s)
      Ishioka Y, Gondo Y, Masui Y, Nakagawa T, Tatsuhira Y, Ogawa M, Ikebe K, Kamide K, Takahashi R, & Arai Y
    • Organizer
      20th International Association of Gerontology and Geriatrics World Congress of Gerontology and Geriatrics
    • Place of Presentation
      Korea
    • Year and Date
      2013-01-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Does Type of Activities Matter? Age and Gender Differences in Leisure Activities Among Japanese Older Adults2013

    • Author(s)
      Ogawa M, Ishioka Y, Gondo Y, Kozono M, Masui Y, Nakagawa T, Tabuchi M , Tatsuhira Y, Ikebe K, Kamide K, Arai Y, Ishizaki T, & Takahashi R
    • Organizer
      20th International Association of Gerontology and Geriatrics World Congress of Gerontology and Geriatrics
    • Place of Presentation
      Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] New successful aging model in the longevity society2013

    • Author(s)
      Gondo Y
    • Organizer
      International Association of Gerontology and Geriatrics World Congress of Gerontology and Geriatrics
    • Place of Presentation
      Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] Complexity of work and late-life cognitive function.2013

    • Author(s)
      Ishioka Y, Gondo Y, Masui Y, Nakagawa T, Tatsuhira Y, Ogawa M, Ikebe K, Kamide K, Takahashi R, & Arai Y.
    • Organizer
      20th International Association of Gerontology and Geriatrics World Congress of Gerontology and Geriatrics,
    • Place of Presentation
      Soul, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] Does Type of Activities Matter? Age and Gender Differences in Leisure Activities Among Japanese Older Adults.2013

    • Author(s)
      Ogawa M, Ishioka Y, Gondo Y, Kozono M, Masui Y, Nakagawa T, Tabuchi M , Tatsuhira Y, Ikebe K, Kamide K, Arai Y, Ishizaki T, & Takahashi R.
    • Organizer
      20th International Association of Gerontology and Geriatrics World Congress of Gerontology and Geriatrics,
    • Place of Presentation
      Soul, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] 井康通, 高橋龍太郎. 前期・後期高齢者の認知機能と仕事の複雑性との関連―SONIC研究の結果より―.2013

    • Author(s)
      石岡良子, 権藤恭之, 増井幸恵, 稲垣宏樹, 小川まどか, 中川 威, 立平起子, 神出 計, 池邉一典, 新 井康通, 高橋龍太郎.
    • Organizer
      第55回老年社会科学大会,
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高齢者の余暇活動と精神的健康の関連―SONIC研究における70歳調査結果より―.2013

    • Author(s)
      小園麻里菜, 権藤恭之, 小川まどか, 石岡良子, 増井幸恵, 中川 威, 立平起子, 神出 計, 池邉一典, 新井康通, 高橋龍太郎.
    • Organizer
      第55回老年社会科学大会,
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] New Successful aging model in the longevity society2013

    • Author(s)
      Gondo Y
    • Organizer
      20th International Association of Gerontology and Geriatrics World Congress of Gerontology and Geriatrics,
    • Place of Presentation
      Soul, Korea
    • Related Report
      2013 Annual Research Report
  • [Book] A complete reference guide, Volume IV, Wellbeing in Later life2014

    • Author(s)
      Gondo Y, Arai Y, Hirose N WILEY
    • Total Pages
      411
    • Publisher
      Wellbeing
    • Related Report
      2013 Final Research Report
  • [Book] Dementia and Memory2014

    • Author(s)
      Gondo Y, Masui Y, Inagaki H Hirose N
    • Total Pages
      250
    • Publisher
      Psychology Press
    • Related Report
      2013 Final Research Report
  • [Book] Wellbeing: A Complete Reference Guide, Volume IV, Wellbeing in Later Life2014

    • Author(s)
      Gondo Y, Arai Y, and Hirose, N
    • Total Pages
      411
    • Publisher
      WILEY
    • Related Report
      2013 Annual Research Report
  • [Book] Dementia and Memory2014

    • Author(s)
      Gondo Y, Masui Y, Inagaki H, and Hirose N
    • Total Pages
      250
    • Publisher
      Psychology Press
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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