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Neural mechanisms of directed forgetting in rats

Research Project

Project/Area Number 24653209
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Experimental psychology
Research InstitutionUniversity of Tsukuba

Principal Investigator

ICHITANI Yukio  筑波大学, 人間系, 教授 (80176289)

Co-Investigator(Kenkyū-buntansha) YAMADA Kazuo  筑波大学, 人間系, 准教授 (30282312)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords指示性忘却 / ラット / 空間記憶 / 放射状迷路課題 / リハーサル / 放射状迷路 / 海馬 / 前頭前野
Research Abstract

"Directed forgetting" is a method and a phenomenon used to investigate whether organisms can control memory with instructions to forget, and to remember. We examined directed forgetting phenomenon in rats using a delay-interposed radial maze task. As a result, we demonstrated the directed forgetting phenomenon in a radial maze task in rats, and suggested that several brain regions including the medial prefrontal cortex and the hippocampal CA3 area are potentially related to the directed forgetting phenomenon of spatial information.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (34 results)

All 2014 2013 2012 Other

All Journal Article (16 results) (of which Peer Reviewed: 15 results) Presentation (14 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Tickling during adolescence alters fear-related and cognitive behaviors in rats after prolonged isolation2014

    • Author(s)
      Hori, M., Yamada, K., Ohnishi, J., Sakamoto, S., Takimoto-Ohnishi, E., Miyabe, S., Murakami, K., & Ichitani, Y
    • Journal Title

      Physiology & Behavior

      Volume: 131 Pages: 62-67

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term effects of traumatic stress on subsequent contextual fear conditioning in rats2014

    • Author(s)
      Ryoke, R., Yamada, K. & Ichitani, Y
    • Journal Title

      Physiology & Behavior

      Volume: 129 Pages: 30-35

    • NAID

      120007136716

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hippocampal BDNF treatment facilitates consolidation of spatial memory in spontaneous place recognition in rats2014

    • Author(s)
      Ozawa, T., Yamada, K. & Ichitani, Y
    • Journal Title

      Behavioural Brain Research

      Volume: 263 Pages: 210-216

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term effects of traumatic stress on subsequent contextual fear conditioning in rats.2014

    • Author(s)
      Ryoke, R., Yamada, K. & Ichitani, Y.
    • Journal Title

      Physiology & Behavior

      Volume: in press

    • NAID

      120007136716

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hippocampal BDNF treatment facilitates consolidation of spatial memory in spontaneous place recognition in rats.2014

    • Author(s)
      Ozawa, T., Yamada, K. & Ichitani, Y.
    • Journal Title

      Behavioural Brain Research

      Volume: 263 Pages: 210-216

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MK-801-induced and scopolamine-induced hyperactivity in rats neonatally treated chronically with MK-801.2014

    • Author(s)
      Furuie, H., Yamada, K. & Ichitani, Y.
    • Journal Title

      Behavioural Pharmacology

      Volume: 24 Pages: 678-683

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MK-801-induced and scopolamine- induced hyperactivity in rats neonatally treated chronically with MK-8012013

    • Author(s)
      Furuie, H., Yamada, K. & Ichitani, Y
    • Journal Title

      Behavioural Pharmacology

      Volume: 24 Pages: 678-683

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Can rats control previously acquired spatial information? Evidence of"directed forgetting"phenomenon in delay-interposed radial maze behavior2013

    • Author(s)
      Kaku, M., Yamada, K. & Ichitani, Y
    • Journal Title

      Behavioural Brain Research

      Volume: 248 Pages: 1-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of number of items and interval length on the acquisition of temporal order discrimination in radial maze in rats2013

    • Author(s)
      Sugita M., Yamada K., Ichitani Y
    • Journal Title

      Learning & Memory

      Volume: 20 Pages: 125-129

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of repeated tickling on conditioned fear and hormonal responses in socially isolated rats2013

    • Author(s)
      Hori, M., Yamada, K., Ohnishi, J., Sakamoto, S., Takimoto-Ohnishi, E., Miyabe, S., Murakami, K,, & Ichitani, Y
    • Journal Title

      Neuroscience Letters

      Volume: 536 Pages: 85-89

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Can rats control previously acquired spatial information? Evidence of “directed forgetting” phenomenon in delay-interposed radial maze behavior.2013

    • Author(s)
      Kaku, M., Yamada, K. & Ichitani, Y.
    • Journal Title

      Behavioural Brain Research

      Volume: 248 Pages: 1-6

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of repeated tickling on conditioned fear and hormonal responses in socially isolated rats.2013

    • Author(s)
      Hori, M., Yamada, K., Ohnishi, J., Sakamoto, S., Takimoto-Ohnishi, E., Miyabe, S., Murakami, K. & Ichitani, Y.
    • Journal Title

      Neuroscience Letters

      Volume: 536 Pages: 85-89

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of number of items and interval length on the acquisition of temporal order discrimination in radial maze in rats.2013

    • Author(s)
      Sugita, M., Yamada, K. & Ichitani, Y.
    • Journal Title

      Learning & Memory

      Volume: 20 Pages: 125-129

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] D-Cycloserine enhances spatial memory in spontaneous place recognition in rats.2012

    • Author(s)
      Ozawa, T., Kumeji, M., Yamada, K. & Ichitani, Y.
    • Journal Title

      Neuroscience Letters

      Volume: 509 Pages: 13-16

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dissociable anterograde amnesic effects of retrosplenial cortex and hippocampal lesions on spontaneous object recognition memory in rats.2012

    • Author(s)
      Haijima, A. & Ichitani, Y.
    • Journal Title

      Hippocampus

      Volume: 22 Pages: 1868-1875

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ラットの放射状迷路行動における作業記憶と参照記憶に対するNMDA受容体遮断薬MK-801の効果2012

    • Author(s)
      高野越史・山田一夫・一谷幸男
    • Journal Title

      筑波大学心理学研究

      Volume: 44 Pages: 17-22

    • NAID

      40019450290

    • Related Report
      2012 Research-status Report
  • [Presentation] Effects of propranolol,β-adrenergic receptor antagonist on stress-induced enhancement of conditioned fear response in rats2013

    • Author(s)
      Ryoke, R., Yamada, K. & Ichitani, Y
    • Organizer
      Society for Neuroscience, 43rd Annual Metting
    • Place of Presentation
      San Diego, CA,米国
    • Year and Date
      2013-11-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of hippocampal AMPA receptors in the retrieval of long-term spontaneous object recognition memory Society for Neuroscience2013

    • Author(s)
      Takano, E., Yamada, K. & Ichitani, Y
    • Organizer
      43rd Annual Metting
    • Place of Presentation
      San Diego, CA,米国
    • Year and Date
      2013-11-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳内βアミロイドの蓄積はラットの居住型迷路における参照記憶障害を引き起こす2013

    • Author(s)
      角正美・山田一夫・一谷幸男・永田博司
    • Organizer
      日本動物心理学会第73回大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2013-09-16
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットの長期自発的物体再認記憶の検索に及ぼすAMPA受容体遮断薬海馬投与の効果2013

    • Author(s)
      高野越史・山田一夫・一谷幸男
    • Organizer
      日本動物心理学会第73回大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2013-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 放射状迷路を用いたラットの時間的順序記憶におけるtemporal lag effectの検討2013

    • Author(s)
      椙田麻菜美・山田一夫・一谷幸男
    • Organizer
      日本動物心理学会第73回大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2013-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 放射状迷路行動におけるラットの指示性忘却 : 忘却手がかり提示タイミングの効果2013

    • Author(s)
      大垣翔子・角正美・山田一夫・一谷幸男
    • Organizer
      日本動物心理学会第73回大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2013-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットの自発的物体再認テストを用いた検索誘導性忘却の検討2013

    • Author(s)
      上野将玄・高野越史・山田一夫・一谷幸男
    • Organizer
      日本動物心理学会第73回大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2013-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 新生仔期MK-801慢性投与ラットの放射状迷路学習に及ぼすDシクロセリンの効果2013

    • Author(s)
      新倉怜・高野越史・山田一夫・一谷幸男
    • Organizer
      第31回日本生理心理学会大会
    • Place of Presentation
      福井大学
    • Year and Date
      2013-05-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of propranolol,β-adrenergic receptor antagonist on stress-induced enhancement of conditioned fear response in rats2012

    • Author(s)
      Ryoke, R., Yamada, K. & Ichitani, Y
    • Organizer
      Society for Neuroscience, 42nd Annual Metting
    • Place of Presentation
      New Orleans, LA,米国
    • Year and Date
      2012-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of hippocampal NMDA receptors in the retrieval of long-term spontaneous object recognition memory2012

    • Author(s)
      Takano, E., Yamada, K. & Ichitani, Y
    • Organizer
      Society for Neuroscience, 42nd Annual Metting
    • Place of Presentation
      New Orleans, LA,米国
    • Year and Date
      2012-10-13
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットの長期自発的物体再認記憶の検索過程における海馬NMDA受容体の役割2012

    • Author(s)
      高野越史・山田一夫・一谷幸男
    • Organizer
      日本動物心理学会第72回大会
    • Place of Presentation
      関西学院大学
    • Year and Date
      2012-05-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 放射状迷路を用いたラットの時間的順序記憶に及ぼすアーム提示間隔の効果2012

    • Author(s)
      椙田麻菜美・山田一夫・一谷幸男
    • Organizer
      日本動物心理学会第72回大会
    • Place of Presentation
      関西学院大学
    • Year and Date
      2012-05-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of propranolol, β-adrenergic receptor antagonist on stress-induced enhancement of conditioned fear response in rats.

    • Author(s)
      Ryoke, R., Yamada, K. & Ichitani, Y.
    • Organizer
      Society for Neuroscience, 43rd Annual Metting
    • Place of Presentation
      San Diego, CA (アメリカ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Role of hippocampal AMPA receptors in the retrieval of long-term spontaneous object recognition memory

    • Author(s)
      Takano, E., Yamada, K. & Ichitani, Y.
    • Organizer
      Society for Neuroscience, 43rd Annual Metting
    • Place of Presentation
      San Diego, CA (アメリカ)
    • Related Report
      2013 Annual Research Report
  • [Book] 感性認知脳科学への招待2013

    • Author(s)
      一谷幸男
    • Total Pages
      199
    • Publisher
      筑波大学出版会
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.kansei.tsukuba.ac.jp/~ichitanilab/

    • Related Report
      2013 Final Research Report
  • [Remarks] 筑波大学大学院人間総合科学研究科 感性認知脳科学専攻行動神経科学分野 一谷・山田研究室

    • URL

      http://www.kansei.tsukuba.ac.jp/~ichitanilab/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 筑波大学大学院人間総合科学研究科感性認知脳科学専攻 行動神経科学分野 一谷・山田グループ

    • URL

      http://www.kansei.tsukuba.ac.jp/~ichitanilab/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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