| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Physiologically based pharmacokinetic (PBPK) model is a mathematical model that describes absorption, distribution, metabolism and excretion (ADME) of chemical substances in a living body. The goal of study is to analyze plasma effects based on simulation results of reactive species (ROS/RNS) generated in liquid by plasma application and their biological effects predicted by a PBPK mode created in this study. Numerical simulations based on a PBPK model needs to be further developed due to the lack of rate constant data in literature. However, the study has deepened our qualitative understanding of the relation of plasma generated reactive species and blood coagulation processes.
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