Analyses of plasma-biosystem interaction by PBPK model simulation
Project/Area Number |
24654195
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Plasma science
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Research Institution | Osaka University |
Principal Investigator |
SATOSHI Hamaguchi 大阪大学, 工学(系)研究科(研究院), 教授 (60301826)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | プラズマ / プラズマ医療 / 生理的薬物動態モデル / PBPKモデル / シミュレーション / PBPKモデル / 生理学的薬物動態モデル / シュミレーション |
Research Abstract |
Physiologically based pharmacokinetic (PBPK) model is a mathematical model that describes absorption, distribution, metabolism and excretion (ADME) of chemical substances in a living body. The goal of study is to analyze plasma effects based on simulation results of reactive species (ROS/RNS) generated in liquid by plasma application and their biological effects predicted by a PBPK mode created in this study. Numerical simulations based on a PBPK model needs to be further developed due to the lack of rate constant data in literature. However, the study has deepened our qualitative understanding of the relation of plasma generated reactive species and blood coagulation processes.
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Report
(3 results)
Research Products
(68 results)