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high-speed detection of absolute steric configuration of proteins in solution using chiral-sensitive nonlinear Raman spectroscopy

Research Project

Project/Area Number 24655004
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Physical chemistry
Research InstitutionUniversity of Tsukuba

Principal Investigator

KANO Hideaki  筑波大学, 数理物質系, 准教授 (70334240)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsキラリティ / ラマン / CARS / 非線形
Research Abstract

In the present study, we used a new laser source, namely white-light laser source to develop a spectroscopic system which is capable of detecting molecular chirality. First, we employed spectral interferometric technique to improve the sensitivity of the system. As a result, we measured real and imaginary parts of the optical electric field due to the chiral CARS process. Next, we introduced two-color (visible and near infra-red) laser pulses into a photonic crystal fiber in order to extend spectral coverage of the white-light laser. With the use of the visible white-light laser source, we have successfully developed CARS-ROA system in visible, and found improvement of the signal-to-noise ratio.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (14 results) (of which Invited: 9 results) Remarks (2 results)

  • [Journal Article] Raman optical activity by coherent anti-Stokes Raman scattering spectral interferometry2013

    • Author(s)
      Kotaro Hiramatsu, Hideaki Kano, Takashi Nagata
    • Journal Title

      Optics Express

      Volume: 21 Issue: 11 Pages: 13515-21

    • DOI

      10.1364/oe.21.013515

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Observation of Raman Optical Activity by Heterodyne-Detected Polarization-Resolved Coherent Anti-Stokes Raman Scattering2012

    • Author(s)
      Kotaro Hiramatsu, Masanari Okuno, Hideaki Kano, Philippe Leproux, Vincent Couderc, Hiro-o Hamaguchi
    • Journal Title

      Physical Review Letters

      Volume: 109 Issue: 8 Pages: 83901-83901

    • DOI

      10.1103/physrevlett.109.083901

    • NAID

      120007137208

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ヘテロダイン検出法によるアキラル・バックグラウンドフリーな光活性測定法の開発2014

    • Author(s)
      平松光太郎
    • Organizer
      第5回キラルサイエンス&テクノロジーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-02-28
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] ヘテロダイン検出法によるアキラルバックグラウンドフリーな光活性測定法の開発2014

    • Author(s)
      平松 光太郎
    • Organizer
      第5回キラルサイエンス&テクノロジーシンポジウム
    • Place of Presentation
      東京・早稲田大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] コヒーレントラマン分光法で見る分子のキラリティー2013

    • Author(s)
      平松光太郎
    • Organizer
      量子エレクトロニクス研究会
    • Place of Presentation
      長野
    • Year and Date
      2013-12-21
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] coherent Raman optical activity spectroscopy2013

    • Author(s)
      Kotaro Hiramatsu
    • Organizer
      spectroscopic studies on molecular chirality
    • Place of Presentation
      Kyoto
    • Year and Date
      2013-12-20
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 白色レーザーを用いた生細胞・生体組織の多光子分光イメージング2013

    • Author(s)
      加納英明
    • Organizer
      第8回表面科学研究会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-18
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Raman optical activity measured by coherent anti-Stokes Raman scattering2013

    • Author(s)
      Kotaro Hiramatsu, Hideaki Kano, Takeshi Nagata
    • Organizer
      ICAVS-7
    • Place of Presentation
      Kobe
    • Year and Date
      2013-08-26
    • Related Report
      2013 Final Research Report
  • [Presentation] コヒーレントラマン分光法でみる分子のキラリティー2013

    • Author(s)
      平松 光太郎
    • Organizer
      量子エレクトロニクス研究会「バイオ・メディカルフォトニクス:基礎と応用の最前線」
    • Place of Presentation
      長野・上智大学軽井沢セミナーハウス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Coherent Raman optical activity spectroscopy2013

    • Author(s)
      Kotaro Hiramatsu
    • Organizer
      Spectroscopic studies on molecular chirality
    • Place of Presentation
      京都・コープイン京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 白色レーザーを用いた生細胞・生体組織の多光子分光イメージング2013

    • Author(s)
      5. 加納 英明
    • Organizer
      第78回表面科学研究会
    • Place of Presentation
      東京・東京工業大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Raman optical activity measured by coherent anti-Stokes Raman scattering2013

    • Author(s)
      Kotaro Hiramatsu, Hideaki Kano, and Takashi Nagata
    • Organizer
      Seventh International Conference on Advanced Vibrational Spectroscopy (ICAVS7)
    • Place of Presentation
      神戸・神戸国際会議場
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] CARS-ROAのショットノイズ限界測定2012

    • Author(s)
      平松光太郎、奥野将成、加納英明、永田敬、濵口宏夫
    • Organizer
      日本分光学会年次講演会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-28
    • Related Report
      2013 Final Research Report
  • [Presentation] CARS-ROAによる分子キラリティーの観測2012

    • Author(s)
      平松光太郎、奥野将成、加納英明、永田敬、濵口宏夫
    • Organizer
      第6回分子科学討論会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-18
    • Related Report
      2013 Final Research Report
  • [Presentation] CARS-ROA による分子キラリティーの観測2012

    • Author(s)
      平松光太郎、奥野将成、加納英明、永田敬、濵口宏夫
    • Organizer
      第6 回分子科学討論会
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] CARS-ROA のショットノイズ限界測定2012

    • Author(s)
      平松光太郎、奥野将成、加納英明、永田敬、濵口宏夫
    • Organizer
      日本分光学会年次講演会
    • Place of Presentation
      東京工業大学(東京)
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.bk.tsukuba.ac.jp/~CARS/carsroa.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 加納研究室

    • URL

      http://www.bk.tsukuba.ac.jp/~CARS/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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