Generation of Chirality Triggered by Sunlight Irradiation and Development of New Asymmetric Catalysts
| Project/Area Number |
24655025
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic chemistry
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| Research Institution | Chiba University |
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Principal Investigator |
SAKAMOTO Masami 千葉大学, 工学(系)研究科(研究院), 教授 (00178576)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 有機光化学 / 有機結晶 / 不斉合成 / 有機合成化学 |
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| Research Abstract |
A new methodology of effective asymmetric synthesis starting from achiral materials without external chiral source was developed. Irradiation of achiral chromonecarboxylic esters in solution afforded crystalline chromone dimers in optically active form. The mechanism of generation of chirality was clarified and the optical purity of the products was attained 80% by examining conditions. Furthermore, the optically active products were utilized as ligands for catalytic asymmetric synthesis using organometallic compounds. Moreover, this methodology was expanded to a new asymmetric synthesis, and the absolute asymmetric synthesis of isoindolinones with high optical purity was achieved by a reaction of 2-benzoylbenzoic acid derivative with amines.
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Report
(3 results)
Research Products
(46 results)
