| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
A new methodology of effective asymmetric synthesis starting from achiral materials without external chiral source was developed. Irradiation of achiral chromonecarboxylic esters in solution afforded crystalline chromone dimers in optically active form. The mechanism of generation of chirality was clarified and the optical purity of the products was attained 80% by examining conditions. Furthermore, the optically active products were utilized as ligands for catalytic asymmetric synthesis using organometallic compounds. Moreover, this methodology was expanded to a new asymmetric synthesis, and the absolute asymmetric synthesis of isoindolinones with high optical purity was achieved by a reaction of 2-benzoylbenzoic acid derivative with amines.
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