Development of novel catalytic system to synthesize delta-aminolevulinic acid

• Project/Area Number: 24655033
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Organic chemistry
• Research Institution: Kobe University
• Principal Investigator: MATSUBARA Ryosuke 神戸大学, 理学(系)研究科(研究院), 准教授 (90401223)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: レブリン酸 / デルタアミノレブリン酸 / 酸化反応

Research Abstract

Levulinic acid is one of biomass compounds; many researchers are looking for effective utilization of levulinic acid. Delta-aminolevulinic acid, a derivative of levulinic acid, is known to be an important bioactive compound. In this project, we aimed for the development of novel catalytic system to enable one to synthesize delta-aminolevulinic acid directly from levulinic acid. Our first study to oxidize alpha-carbon of ketone using an oxygen radical failed, so we next tried the oxidation using an iron catalyst. During the investigation, we could develop the large-scale synthetic method of the nitrogen-containing ligand of the iron catalyst.

Research Products

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  • URL: http://www2.kobe-u.ac.jp/~ryomatsu/index.html