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Absolute concentration measurement and experimental detection equipment of singlet oxygen on the basis of a new principle

Research Project

Project/Area Number 24655060
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Analytical chemistry
Research InstitutionYokohama National University

Principal Investigator

YAGI Mikio  横浜国立大学, 工学研究院, 教授 (00107369)

Co-Investigator(Kenkyū-buntansha) KIKUCHI Azusa  横浜国立大学, 工学研究院, 准教授 (30452048)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords一重項酸素 / 近赤外発光 / 電子常磁性共鳴 / りん光 / 活性酸素 / 紫外線吸収剤 / サンスクリーン剤
Research Abstract

Singlet oxygen, the lowest excited state of molecular oxygen, is a representative of reactive oxygen species and is of much interest because of its importance in many photosensitized oxidations, in photocarcinogenisis, and in the photodynamic therapy of cancer. Recently, many kinds of techniques have been employed to improve the sensitivity of the detector. However, the currently used technology has important limitations of quantitative information about singlet oxygen concentration which need to be overcome.
It is notable that singlet oxygen is paramagnetic owing to its angular momentum and ground-state oxygen is also paramagnetic. In the present work, we observed the electron paramagnetic resonance (EPR) spectra of singlet oxygen. We have succeeded in determining the absolute concentration of singlet oxygen by using ground-state oxygen as a quantitative standard. We made an experimental equipment to observe the EPR and near-IR emission spectra of singlet oxygen at the same time.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (29 results)

All 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 2 results) Presentation (18 results) Remarks (3 results)

  • [Journal Article] Photoexcited States of UV Absorbers, Benzophenone Derivatives2014

    • Author(s)
      Ryo Kumasaka, Azusa Kikuchi, and Mikio Yagi
    • Journal Title

      Photochem. Photobiol.

      Volume: 90 Issue: 4 Pages: 727-733

    • DOI

      10.1111/php.12257

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Triplet-Triplet Energy Transfer from a UV-A Absorber Butylmethoxydibenzoylmethane to UV-B Absorbers2014

    • Author(s)
      Azusa Kikuchi, Nozomi Oguchi-Fujiyama, Kazuyuki Miyazawa, and Mikio Yagi
    • Journal Title

      Photochem. Photobiol.

      Volume: 90 Issue: 3 Pages: 511-516

    • DOI

      10.1111/php.12222

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 新規UV-B吸収剤 : ジオクチルメトキシベンジリデンマロネートの設計とUV-A吸収剤光安定化効果2013

    • Author(s)
      小口希,宮沢和之,菊地あづさ,八木幹雄
    • Journal Title

      日本化粧品技術者会誌

      Volume: 47 Pages: 209-215

    • NAID

      130005099435

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photoexcited Singlet and Triplet States of a UV Absorber Ethylhexyl Methoxycrylene2013

    • Author(s)
      A. Kikuchi, Y. Hata, R. Kumasaka, Y. Nanbu and M. Yagi
    • Journal Title

      Photochem. Photobiol.

      Volume: 89 Issue: 3 Pages: 523-528

    • DOI

      10.1111/php.12017

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optical and Time-Resolved Electron Paramagnetic Resonance Studies of the Excited States of UV-B Absorber (4-Methoxybenzylidene)camphor2013

    • Author(s)
      A. Kikuchi
    • Journal Title

      J. Phys. Chem. A

      Volume: 117 Issue: 7 Pages: 1413-1419

    • DOI

      10.1021/jp3071772

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Excited states of menthyl anthranilate : a UV-A absorber2013

    • Author(s)
      Azusa Kikuchi, Kenji Shibata, Ryo Kumasaka, Mikio Yagi
    • Journal Title

      Photochemical &. Photobiological Sciences

      Volume: 12 Issue: 2 Pages: 246-253

    • DOI

      10.1039/c2pp25190f

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 新規UV-B吸収剤:ジオクチルメトキシベンジリデンマロネートの設計とUV-A吸収剤光安定化効果2013

    • Author(s)
      小口 希,宮沢和之,菊地あづさ,八木幹雄
    • Journal Title

      日本化粧品技術者会誌

      Volume: 47

    • NAID

      130005099435

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Photophysical Properties of Dioctyl 4-Methoxybenzylidenemalonate: UV-B Absorber2012

    • Author(s)
      N. Oguchi-Fujiyama
    • Journal Title

      Photochem. Photobiol. Sci.

      Volume: 11 Issue: 10 Pages: 1528-1535

    • DOI

      10.1039/c2pp25101a

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] サリチル酸エステル系紫外線吸収剤の光励起状態と一重項酸素の光増感生成2014

    • Author(s)
      杉山一翔,菊地あづさ,八木幹雄
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 紫外線吸収剤アミノ安息香酸誘導体による一重項酸素の光増感生成と消光2014

    • Author(s)
      屋中智生,菊地あづさ,八木幹雄
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] サリチル酸エステル系紫外線吸収剤の光励起状態と一重項酸素の光増感生成2014

    • Author(s)
      杉山一翔・菊地あづさ・八木幹雄
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋市名古屋大学東山キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 紫外線吸収剤アミノ安息香酸誘導体による一重項酸素の光増感生成と消光2014

    • Author(s)
      屋中 智生・菊地 あづさ・八木 幹雄
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋市名古屋大学東山キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 紫外線吸収剤による一重項酸素の光増感生成と消光2013

    • Author(s)
      熊坂亮,杉山一翔,平本祐也,屋中智生,菊地あづさ,八木幹雄
    • Organizer
      第52回電子スピンサイエンス学会年会
    • Place of Presentation
      さいたま市大宮ソニック市民ホール
    • Year and Date
      2013-10-25
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 紫外線吸収剤からの一重項酸素の光増感生成2013

    • Author(s)
      熊坂亮,菊地あづさ,八木幹雄
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Year and Date
      2013-03-24
    • Related Report
      2013 Final Research Report
  • [Presentation] UV-AおよびUV-B領域に吸収帯を有する新規紫外線吸収剤の合成と光励起状態2013

    • Author(s)
      南部祐一,菊地あづさ,八木幹雄
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Year and Date
      2013-03-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 紫外線吸収剤ジオクチルヒドロキシジメトキシベンジリデンマロネートの光励起状態2013

    • Author(s)
      平本祐也,菊地あづさ,八木幹雄
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Year and Date
      2013-03-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 紫外線吸収剤ベンゾトリアゾール誘導体の光励起状態2013

    • Author(s)
      杉山一翔,菊地あづさ,八木幹雄
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス
    • Year and Date
      2013-03-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 有機系紫外線吸収剤からの一重項酸素の光増感生成2013

    • Author(s)
      熊坂 亮,菊地 あづさ,八木 幹雄
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学
    • Related Report
      2012 Research-status Report
  • [Presentation] UV-AおよびUV-B領域に吸収帯を有する新規紫外線吸収剤の合成と光励起状態2013

    • Author(s)
      南部 祐一,菊地 あづさ,八木 幹雄
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 紫外線吸収剤ジオクチルヒドロキシジメトキシベンジリデンマロネートの光励起状態2013

    • Author(s)
      平本 祐也,菊地 あづさ,八木 幹雄
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 紫外線吸収剤ベンゾトリアゾール誘導体の光励起状態2013

    • Author(s)
      杉山 一翔,菊地 あづさ,八木 幹雄
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学
    • Related Report
      2012 Research-status Report
  • [Presentation] UV-A吸収剤アントラニル酸メンチルの励起状態と緩和過程2012

    • Author(s)
      菊地あづさ,芝田謙二,熊坂亮,八木幹雄
    • Organizer
      第51回電子スピンサイエンス学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2012-11-01
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 紫外線吸収剤ベンゾフェノン-3およびベンゾフェノン-6のりん光増強現象2012

    • Author(s)
      熊坂亮,菊地あづさ,八木幹雄
    • Organizer
      2012年光化学討論会
    • Place of Presentation
      東京工業大学大岡山キャンパス
    • Year and Date
      2012-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] UV-B吸収剤Dioctyl 4-Methoxybenzylidenemalonateの励起状態と光安定性2012

    • Author(s)
      小口希,宮沢和之,菊地あづさ,八木幹雄
    • Organizer
      2012年光化学討論会
    • Place of Presentation
      東京工業大学大岡山キャンパス
    • Year and Date
      2012-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 紫外線吸収剤ベンゾフェノン-3およびベンゾフェノン-6のりん光増強現象2012

    • Author(s)
      熊坂 亮,菊地 あづさ,八木 幹雄
    • Organizer
      2012年光化学討論会
    • Place of Presentation
      東京工業大学
    • Related Report
      2012 Research-status Report
  • [Presentation] UV-B吸収剤Dioctyl 4-Methoxybenzylidenemalonateの励起状態と光安定性2012

    • Author(s)
      小口 希,宮沢 和之,菊地 あづさ,八木 幹雄
    • Organizer
      2012年光化学討論会
    • Place of Presentation
      東京工業大学
    • Related Report
      2012 Research-status Report
  • [Remarks] 活性酸素の研究(八木・菊地研究室ホームページ)

    • URL

      http://www.chem.ynu.ac.jp/lab/yagilab/oxygen.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 八木・菊地研究室ホームページ(活性酸素の研究)

    • URL

      http://www.chem.ynu.ac.jp/lab/yagilab/oxygen.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 八木・菊地研究室

    • URL

      http://www.chem.ynu.ac.jp/lab/yagilab/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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