How does dolphin detoxify mercury?
Project/Area Number |
24655065
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Single-year Grants |
Research Field |
Analytical chemistry
|
Research Institution | Ehime University |
Principal Investigator |
AGUSA Tetsuro 愛媛大学, 沿岸環境科学研究センター, 特任助教 (50403853)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 水銀 / セレン / 解毒作用 / 海棲高等動物 / 環境化学 / 環境毒性学 / 分析化学 / メタロミクス |
Research Abstract |
Higher trophic marine animals accumulate a large amount of Hg in the liver. Most of Hg exists as tiemannite (HgSe) in those mammals. This compound is assumed to be an inert end product of the Hg detoxification process. However, it is still unknown the mechanism of HgSe formation. To understand the detoxification process of Hg, we investigated Hg binding proteins in the hepatic cytosol of the higher trophic marine animals. By the purification of proteins interacted with Hg using an anion exchange and a gel filtration columns and an inductively coupled plasma - mass spectrometer (ICP-MS), four proteins with the molecular weight around 100 kDa and 40 kDa were obtained in the cytosol fraction of the northern fur seal (Callorhinus ursinus). The purified proteins may play a significant role in the formation of Hg-Se complex in the hepatic cytosol.
|
Report
(3 results)
Research Products
(46 results)
-
[Journal Article] Exposure assessment of lead to workers and children in the battery recyclingcraft village, Dong Mai, Vietnam.2014
Author(s)
Noguchi T, Itai T, Tue NM, Agusa T, Ha NN, Horai S, Trang PTK, Viet PH, Takahashi s, Tanabe S.
-
Journal Title
Journal of Material Cycles and Waste Management
Volume: 16
Issue: 1
Pages: 46-51
DOI
Related Report
Peer Reviewed
-
[Journal Article] Human exposure to arsenic from drinking water in Vietnam2014
Author(s)
Agusa, T., Trang, P. T. K., Lan, V. M., Anh, D. H., Tanabe, S., Viet, P. H. and Berg, M.
-
Journal Title
Science of the Total Environment
Volume: in press
Pages: 562-569
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Exposure, metabolism, and toxic effect of arsenic in residents from arsenic-contaminated groundwater areas of southeast Asia, In Kawaguchi, M.. Misaki, K., Sato, H., Yokokawa, T., Itai, T. , Nguyen, T. M., Ono, J., Tanabe S. (Eds.)2012
Author(s)
Agusa, T., Kunito, T., Kubota, R., Tanabe, S., Iwata, H.
-
Journal Title
International Symposium on Advanced Studies by Young Scientists on Environmental Pollution and Ecotoxicology, TERRAPUB, Tokyo
Pages: 125-132
Related Report
-
-
-
-
-
-
-
-
[Presentation] (2014) Characterization of mercury binding proteins in the liver of northern fur seals (Callorhinus ursinus)2014
Author(s)
Agusa, T., Yasugi, S., Ikemoto, T., Kunito, T., Baba, N., Tanabe, S., Iwata, H
Organizer
The Society of Toxicology (SOT) 53rd Annual Meeting
Place of Presentation
Phoenix, Arizona, USA, Abstract 335
Related Report
-
[Presentation] Characterization of mercury binding proteins in the liver of northern fur seals (Callorhinus ursinus)2014
Author(s)
Agusa, T., Yasugi, S., Ikemoto, T., Kunito, T., Baba, N., Tanabe, S., Iwata, H.
Organizer
The Society of Toxicology (SOT) 53rd Annual Meeting
Place of Presentation
Phoenix, Arizona, USA
Related Report
-
[Presentation] (2013) Arsenic exposure and susceptibility in Vietnamese2013
Author(s)
Agusa, T., Kunito, T., Inoue, S., Minh, T.B., Tue, N.M., Ha, N.N., Tu, N.P.C., Trang, P.T.K., Fujihara, J., Takeshita, H., Takahashi, S., Tuyen, B.C., Viet, P.H., Iwata, H., Tanabe, S
Organizer
NIES Arsenic Workshop 2013 ~Seeking ways to reduce the arsenic health hazards from the roxicological standpoint~
Place of Presentation
Tsukuba, Japan, Abstracts, p.12
Year and Date
2013-12-10
Related Report
Invited
-
[Presentation] Occupational exposure to trace elements in e-waste recycling workers; case studies from the Philippines and India2013
Author(s)
Agusa, T., Takigami, H., Eguchi, A., Fujimori, T., Bekki, K., Yoshida, A., Terazono, A., Ballesteros Jr., F.C., Ha, N.N., Ramu, K., Murata, S., Parthasaraty, P., Bulbule, K.A., Takahashi, S., Subramanian, A., Iwata, H., Tanabe, S
Organizer
Workshop for Knowledge Sharing on E-waste in Thailand (The 9th NIES Workshop on E-Waste)
Place of Presentation
Bangkok, Thailand(ページ番号無し)
Year and Date
2013-01-31
Related Report
Invited
-
[Presentation] Arsenic, manganese and barium contamination in groundwater and their human exposure in Vietnam2013
Author(s)
Agusa, T., Kunito, T., Inoue, S., Minh, T.B., Tue, N.M., Ha, N.N., Tu, N.P.C., Trang, P.T.K., Takahashi, S., Tuyen, B.C., Viet, P.H., Iwata, H., Tanabe, S
Organizer
Japan-Vietnam Joint Workshop on"Current Challenges for Managing Environmental Issues and Waste Recycling in Northern Vietnam"
Place of Presentation
Hanoi, Vietnam, Abstract book, 14
Year and Date
2013-01-08
Related Report
-
[Presentation] (2013) Associations of single nucleotide polymorphisms and haplotypes in arsenic [+3 oxidation state] methyltransferase (AS3MT) with arsenic metabolism : A case study in arsenic contaminated areas from Vietnam2013
Author(s)
Agusa, T., Kunito, T., Tue, N.M., Lan, V.T.M., Minh, T.B., Trang, P.T.K., Fujihara, J., Takeshita, H., Takahashi, S., Viet, P.H., Tanabe, S., Iwata, H
Organizer
The Society of Toxicology (SOT) 52nd Annual Meeting
Place of Presentation
San Antonio, Texsas, USA, Abstract 318
Related Report
-
[Presentation] (2013) Identification of Quantitative Trait Loci (QTL) Associated with Inorganic Arsenic Metabolism using Recombinant Inbred Strains of Mice2013
Author(s)
Agusa, T., Komori, H., Soga, Y., Nose, M., Mori, S., Kubota, R., Tanabe, S., Iwata, H
Organizer
The XIII International Congress of Toxicology (ICT 2013)
Place of Presentation
Seoul, South Korea, Abstract Book, 205
Related Report
-
[Presentation] 組換え近交系マウスを用いたヒ素感受性遺伝子座の同定2013
Author(s)
阿草哲郎, 小森浩章, 曽我美子, 宮崎龍彦, 能勢眞人, 森士朗, 久保田領志, 田辺信介, 岩田久人
Organizer
第24回日本微量元素学会
Place of Presentation
吹田, プログラム・抄録集, 103
Related Report
-
[Presentation] バイカルアザラシの微量元素蓄積とその応答遺伝子の探索2013
Author(s)
阿草哲郎, 平川周作, 渡邉泉, 池本徳孝, 宇高真行, 金恩英, Evgeny A. Petrov, Valeriy B. Batoev, 田辺信介, 岩田久人
Organizer
第22回環境化学討論会
Place of Presentation
府中, 講演要旨集(in CD), 1-1B-2-1
Related Report
-
[Presentation] ベトナム人におけるAS3MT遺伝子の発現量とSNPsの関係2013
Author(s)
阿草哲郎, 國頭恭, Nguyen Minh Tue, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, 藤原純子, 竹下治男, 高橋真, Pham Hung Viet, 田辺信介, 岩田久人
Organizer
第19回ヒ素シンポジウム
Place of Presentation
福岡, 講演要旨集, 62-63
Related Report
-
[Presentation] Arsenic exposure and susceptibility in Vietnamese2013
Author(s)
Agusa, T., Kunito, T., Inoue, S., Minh, T.B., Tue, N.M., Ha, N.N., Tu, N.P.C., Trang, P.T.K., Fujihara, J., Takeshita, H., Takahashi, S., Tuyen, B.C., Viet, P.H., Iwata, H., Tanabe, S.
Organizer
NIES Arsenic Workshop 2013 ~Seeking ways to reduce the arsenic health hazards from the toxicological standpoint~
Place of Presentation
Tsukuba, Japan
Related Report
Invited
-
[Presentation] Identification of Quantitative Trait Loci (QTL) Associated with Inorganic Arsenic Metabolism using Recombinant Inbred Strains of Mice2013
Author(s)
Agusa, T., Komori, H., Soga, Y., Nose, M., Mori, S., Kubota, R., Tanabe, S., Iwata, H.
Organizer
The XIII International Congress of Toxicology (ICT 2013)
Place of Presentation
Seoul, South Korea
Related Report
-
-
-
[Presentation] ベトナム人におけるAS3MT遺伝子の発現量とSNPsの関係2013
Author(s)
阿草哲郎, 國頭 恭, Nguyen Minh Tue, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, 藤原純子, 竹下治男, 高橋 真, Pham Hung Viet, 田辺信介, 岩田久人
Organizer
第19回ヒ素シンポジウム
Place of Presentation
福岡
Related Report
-
[Presentation] Arsenic, manganese and barium contamination in groundwater and their human exposure in Vietnam2013
Author(s)
Agusa, T., Kunito, T., Inoue, S., Minh, T.B., Tue, N.M., Ha, N.N., Tu, N.P.C., Trang, P.T.K., Takahashi, S., Tuyen, B.C., Viet, P.H., Iwata, H., Tanabe, S.
Organizer
Japan-Vietnam Joint Workshop on “Current Challenges for Managing Environmental Issues and Waste Recycling in Northern Vietnam
Place of Presentation
Hanoi, Vietnam
Related Report
Invited
-
[Presentation] Occupational exposure to trace elements in e-waste recycling workers; case studies from the Philippines and India2013
Author(s)
Agusa, T.,, Takigami, H., Eguchi, A., Fujimori, T., Bekki, K., Yoshida, A., Terazono, et al.
Organizer
Workshop for Knowledge Sharing on E-waste in Thailand (The 9th NIES Workshop on E-Waste)
Place of Presentation
Bangkok, Thailand
Related Report
Invited
-
[Presentation] Associations of single nucleotide polymorphisms and haplotypes in arsenic [+3 oxidation state] methyltransferase (AS3MT) with arsenic metabolism: A case study in arsenic contaminated areas from Vietnam2013
Author(s)
Agusa, T., Kunito, T., Tue, N.M., Lan, V.T.M., Minh, T.B., Trang, P.T.K., Fujihara, J., Takeshita, H., Takahashi, S., Viet, P.H., Tanabe, S., Iwata, H.
Organizer
The Society of Toxicology (SOT) 52nd Annual Meeting
Place of Presentation
San Antonio, USA
Related Report
-
[Presentation] Associations of 18 single nucleotide polymorphisms in As [+3 oxidation state] methyltransferase (AS3MT) with As methylation capacity in Vietnamese2012
Author(s)
Agusa, T., Kunito, T., Tue, N.M., Lan, V.T.M., Minh, T.B., Trang, P.T.K., Fujihara, J., Takeshita, H., Takahashi, S., Viet, P.H., Tanabe, S., Iwata, H
Organizer
The Ottawa 2012 International Symposium on Biochemistry & Biophysics
Place of Presentation
Ottawa, Canada, PROGRAM & ABSTRACT BOOK, 114-115
Year and Date
2012-10-25
Related Report
Invited
-
-
[Presentation] (2012) Accumulation feature of trace elements in mass-stranded harbor seals (Phoca vitulina) in the North Sea coast in 20022012
Author(s)
Agusa, T., Yasugi, S., Iida, A., Ikemoto, T., Anan, Y., Kuiken, T., Osterhaus, A.D.M.E., Tanabe, S., Iwata, H
Organizer
SETAC (Society of Environmental Toxicology and Chemistry) North America 33rd Annual Meeting
Place of Presentation
Long Beach, California, USA, Abstract Book, 207-208
Related Report
-
[Presentation] ベトナム人の無機ヒ素メチル化能力とAS3MTのSNPsの関係2012
Author(s)
阿草哲郎, 國頭恭, Nguyen Minh Tue, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, 高橋真, 藤原純子, 竹下治男, Pham Hung Viet、田辺信介、岩田久人
Organizer
第23回日本微量元素学会
Place of Presentation
東京都千代田区, 抄録集, 171
Related Report
-
[Presentation] ヒ素代謝・排泄に関与する感受性遺伝子の探索2012
Author(s)
阿草哲郎, 小森浩章, 曽我美子, 宮崎龍彦, 能勢眞人, 森士朗, 久保田領志, 田辺信介, 岩田久人
Organizer
第21回環境化学討論会
Place of Presentation
松山, 講演要旨集(in CD), 2D-15
Related Report
-
[Presentation] インドおよびフィリピンのe-wasteリサイクル労働者における微量元素曝露の実態2012
Author(s)
阿草哲郎, 滝上英孝, 藤森崇, 江口哲史, 戸次加奈江, 吉田綾, 寺園淳, Florencio C. Ballesteros Jr., Keshav A. Bulbule, Peethmbaram Parthasaraty, 高橋真, Annamalai Subramanian, 岩田久人, 田辺信介
Organizer
第21回環境化学討論会
Place of Presentation
松山, 講演要旨集(in CD), P-012
Related Report
-
-
[Presentation] アジア途上国における地下水のヒ素汚染とヒトへの影響2012
Author(s)
阿草哲郎、岩田久人 ,國頭恭, 井上英, 久保田領志, Karri Ramu, Tu Binh Minh, Nguyen Minh Tue, Nguyen Ngoc Ha, Nguyen Phuc Cam Tu, 藤原純子, Paromita Charaborty, Chhoun Chamnan, Pham Thi Kim Trang, Alissara Reungsang, Kriengsak Srisuk, 中村哲, 滝沢智, 竹下治男, 高橋真, Annamalai Subramanian, Bui Cach Tuyen, Pham Hung Viet, Touch Seang Tana, 田辺信介
Organizer
第18回ヒ素シンポジウム
Place of Presentation
宮崎, 講演要旨集, 40-41
Related Report
-
[Presentation] Associations of 18 single nucleotide polymorphisms in As [+3 oxidation state] methyltransferase (AS3MT) with As methylation capacity in Vietnamese2012
Author(s)
Agusa, T., Kunito, T., Tue, N.M., Lan, V.T.M., Minh, T.B., Trang, P.T.K., Fujihara, J., Takeshita, H., Takahashi, S., Viet, P.H., Tanabe, S., Iwata, H.
Organizer
he Ottawa 2012 International Symposium on Biochemistry & Biophysics
Place of Presentation
Ottawa, Canada
Related Report
Invited
-
[Presentation] Accumulation feature of trace elements in mass-stranded harbor seals (Phoca vitulina) in the North Sea coast in 20022012
Author(s)
Agusa, T., Yasugi, S., Iida, A., Ikemoto, T., Anan, Y., Kuiken, T., Osterhaus, A.D.M.E., Tanabe, S., Iwata, H.
Organizer
SETAC (Society of Environmental Toxicology and Chemistry) North America 33rd Annual Meeting
Place of Presentation
Long Beach, USA
Related Report
-
-
-
-
-
-
-