Recognition of Ionic Polymers by Self-Assembled Macrocyclic Compounds
| Project/Area Number |
24655095
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Polymer chemistry
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
ITOH Yoshimitsu 東京大学, 工学(系)研究科(研究院), 助教 (00531071)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 大環状化合物 / 環状ペプチド / 超分子ポリマー / リン酸認識 / ナノチャネル / ホスト－ゲスト / 分子認識 |
|---|
| Outline of Final Research Achievements |
Most of the biomolecules can be regarded as an ionic polymer. Biological events are strongly related to the recognition of those polymers by biomacromolecules. In this research, we synthesized bio-inspired peptidic macrocycles and succeeded in recognizing polymeric phosphate anion though nanotubular self-assembly. We also clarified that the polymeric phosphate anion binds to the inner cavity of the nanotube. During the investigation, we also found a preferential assembly of the same enantiomers of the peptidic macrocycles which is rarely observed in supramolecular system.
|
Report
(4 results)
Research Products
(11 results)
