Recognition of Ionic Polymers by Self-Assembled Macrocyclic Compounds

• Project/Area Number: 24655095
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Polymer chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: ITOH Yoshimitsu 東京大学, 工学(系)研究科(研究院), 助教 (00531071)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 大環状化合物 / 環状ペプチド / 超分子ポリマー / リン酸認識 / ナノチャネル / ホスト－ゲスト / 分子認識

Outline of Final Research Achievements

Most of the biomolecules can be regarded as an ionic polymer. Biological events are strongly related to the recognition of those polymers by biomacromolecules. In this research, we synthesized bio-inspired peptidic macrocycles and succeeded in recognizing polymeric phosphate anion though nanotubular self-assembly. We also clarified that the polymeric phosphate anion binds to the inner cavity of the nanotube. During the investigation, we also found a preferential assembly of the same enantiomers of the peptidic macrocycles which is rarely observed in supramolecular system.

Research Products

• [Journal Article] Homochiral Supramolecular Polymerization of Bowl-shaped Chiral Macrocycles in Solution (2014)
  • Author(s): Kohei Sato, Yoshimitsu Itoh and Takuzo Aida
  • Journal Title: Chemical Science Volume: 5 Issue: 1 Pages: 136-140
  • DOI: 10.1039/c3sc52449c
  • Peer Reviewed
• [Presentation] Development of Self-assembling Fluorous Nanochannels for Ultrafast Water Transportation (2014)
  • Author(s): Takeshi Konda, Kohei Sato, Yoshimitsu Itoh, Takuzo Aida
  • Organizer: 63th SPSJ Annual Meeting
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2014-05-28
• [Presentation] 大環状オリゴアミドのカラム状自己組織化(1) コアのキラリティに起因する立体特異的自己組織化- (2013)
  • Author(s): 佐藤浩平，伊藤喜光，相田卓三
  • Organizer: 第93回日本化学会春季年会
  • Place of Presentation: 立命館大学、滋賀県
• [Presentation] 大環状オリゴアミドのカラム状自己組織化(2) -多孔質液晶のゲストイオン包接- (2013)
  • Author(s): 横溝紗希，佐藤浩平，伊藤喜光，相田卓三
  • Organizer: 第93回日本化学会春季年会
  • Place of Presentation: 立命館大学、滋賀県
• [Presentation] 大環状オリゴアミドのカラム状自己組織化(3) -有機フッ素ナノチャネルに向けて- (2013)
  • Author(s): 誉田剛士，佐藤浩平，伊藤喜光，相田卓三
  • Organizer: 第93回日本化学会春季年会
  • Place of Presentation: 立命館大学、滋賀県
• [Presentation] 液晶性大環状ペプチドのカラム状自己組織化 (2013)
  • Author(s): 佐藤浩平、伊藤喜光，相田卓三
  • Organizer: 2012年日本液晶学会討論会
  • Place of Presentation: 千葉大学、千葉県
• [Presentation] 大環状ペプチドの一次元自己組織化と新機能開拓(1): 異方的多孔質材料の開発 (2012)
  • Author(s): 佐藤浩平，伊藤喜光，相田卓三
  • Organizer: 第61回高分子学会年次大会
  • Place of Presentation: パシフィコ横浜、神奈川県
• [Presentation] 大環状ペプチドの一次元自己組織化と新機能開拓(2): 生体関連リン酸イオンの認識 (2012)
  • Author(s): 横溝紗希，佐藤浩平，伊藤喜光，相田卓三
  • Organizer: 第61回高分子学会年次大会
  • Place of Presentation: パシフィコ横浜、神奈川県
• [Presentation] Columnar Liquid Crystalline Peptidic Macrocycles (2012)
  • Author(s): Kohei Sato, Yoshimitsu Itoh, Takuzo Aida
  • Organizer: 1st International Conference on Emerging Advanced Nanomaterials
  • Place of Presentation: Australia, Brisbane
• [Presentation] One-Dimensional Assembly of a Peptidic Macrocycle Synchronous to Phosphate Anion Inclusion (2012)
  • Author(s): Saki Yokomizo, Kohei Sato, Yoshimitsu Itoh, Takuzo Aida
  • Organizer: 1st International Conference on Emerging Advanced Nanomaterials
  • Place of Presentation: Australia, Brisbane
• [Presentation] Encapsulation of Fullerenes by Columnar Liquid Crystalline Bowl-Shaped Peptidic Macrocycle
  • Author(s): 佐藤浩平，伊藤喜光，相田卓三
  • Organizer: 第94回日本化学会春季年会
  • Place of Presentation: 名古屋大学、愛知県