Development of structured PEG for protein manipulation
| Project/Area Number |
24655112
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional materials chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ポリエチレングリコール / ペンタエリスリトール / 凝集抑制効果 / タンパク質 |
|---|
| Research Abstract |
Influences of topology and amphiphilicity of poly(ethylene glycol) were studied. Triangle poly(ethylene glycol) derivative was synthesized by combining tetra ethylene glycol and pentaerythritol, which showed lower dehydration temperature than the linear counterpart. Furthermore, it was found that the triangle poly(ethylene glycol) has protein stabilization effect. Phenyl-appended poly(ethylene glycol)s were also synthesized and the difference of the poly(ethylene glycol) chain affected the assembling property in water.
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Report
(3 results)
Research Products
(71 results)
