| Project/Area Number |
24655157
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyushu University |
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Principal Investigator |
MIURA Yoshiko 九州大学, 工学(系)研究科(研究院), 教授 (00335069)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 糖鎖 / 高分子 / ナノゲル粒子 / バイオセンサー / レクチン / 細胞成長因子 / 糖鎖高分子 / 高分子ナノゲル / バイオ計測 / 硫酸化糖 / バイオセンシング / グリコサミノグリカン / ナノゲル |
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| Research Abstract |
The glycopolymer nanogel were synthesized, and the molecular recognition ability was investigated with proteins such as sugar recognition protein (lectin) and cell growth factors. Since the glycopolymer nanogel particles have three dimensional molecular recognition space, the glycopolymer nanogel particles showed the strong and specific recognition to the target proteins. We utilized the molecular recognition ability of glyconanoparticle for biosensing, and found the glycopolymer nanoparticles showed the strong and specific recognition ability in the structural color biosensor like antigen. On the other hand, the sulfated glyconanoparticles showed the specific molecular recognition ability to cell growth factor. The glyconanoparticles also showed the strong and specific recognition to the target protein in the cell.
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