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Synthesis and Environmental Application of Dopamine: Poly-gamma-Glutamate Supragels

Research Project

Project/Area Number 24655209
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Polymer/Textile materials
Research InstitutionKochi University

Principal Investigator

ASHIUCHI Makoto  高知大学, 教育研究部総合科学系, 教授 (20271091)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords環境材料 / 環境技術 / 環境機能 / バイオポリアミド / 化学改質 / 超分子ゲル / 金属吸着
Outline of Final Research Achievements

It is well known that the enriched catechol residues are found in mussel’s byssus showing a high adherent ability in water. We hence tried to replace the hexadecylpyridinium moieties of a stoichiometric poly-gamma-glutamate ion-complex (PGAIC) with dopamine molecules and succeeded in developing dopamine:PGA supragels at room temperature without risky chemicals/expensive catalysts. This new material was tentatively called dopamyl PGA (dmPGA). The rheological research implied that dmPGA possesses potential as self-healing gels. Furthermore, the metal adsorption tests indicated that the capabilities (particularly for divalent cations) of dmPGA, along with a hyperbolic curve, are much superior to PGA and polyacrylate, suggesting its potential application for the effective (simultaneous) removal of various toxic metals.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (47 results)

All 2015 2014 2013 2012

All Journal Article (11 results) (of which Peer Reviewed: 9 results) Presentation (28 results) (of which Invited: 6 results) Book (4 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Extra-chromosomal DNA maintenance in Bacillus subtilis, dependence on flagellation factor FliF and moonlighting mediator EdmS2015

    • Author(s)
      Yuichi Hakumai, Kouko Shimomoto, Makoto
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 460 Pages: 1059-1062

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid purification and plasticization of D-glutamate-containing poly-γ-glutamate from Japanese fermented soybean food natto2015

    • Author(s)
      Makoto Ashiuchi, Shota Oike, Hirofumi Hakuba, Shigeo Shibatani, Nogiho Oka, Taisuke Wakamatsu
    • Journal Title

      Journal of Pharmaceutical and Biomedical Analysis

      Volume: - Pages: 90-93

    • DOI

      10.1016/j.jpba.2015.01.031

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bacillus subtilis EdmS (formerly PgsE) participates in the maintenance of episomes2013

    • Author(s)
      Makoto Ashiuchi, Daisuke Yamashiro, Kento Yamamoto
    • Journal Title

      Plasmid

      Volume: 70 Pages: 209-215

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] NRPSs and amide ligases producing homopoly(amino acid)s and homooligo(amino acid)s2013

    • Author(s)
      Yoshimitsu Hamano, Toshinobu Arai, Makoto Ashiuchi, Kuniki Kino
    • Journal Title

      Natural Product Reports

      Volume: 30 Pages: 1087-1097

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microbial production and chemical transformation of poly-γ-glutamate2013

    • Author(s)
      Makoto Ashiuchi
    • Journal Title

      Microbial Biotechnology

      Volume: 6 Pages: 664-674

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] ポリ-γ-グルタミン酸イオンコンプレックスを基礎とする新規バイオプラスチック素材の抗菌性2013

    • Author(s)
      芦内 誠、福島賢三、大矢遥那、柴谷滋郎、白馬弘文
    • Journal Title

      日本生物工学会トピックス集

      Volume: なし Pages: 19-20

    • Related Report
      2013 Research-status Report
  • [Journal Article] Bacillus subtilis EdmS (formerly PgsE) participates in the maintenance of episomes2013

    • Author(s)
      M. Ashiuchi, D. Yamashiro, K. Yamamoto
    • Journal Title

      Plasmid

      Volume: 印刷中 Issue: 2 Pages: 209-215

    • DOI

      10.1016/j.plasmid.2013.03.008

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of antimicrobial thermoplastic material from archaeal poly-γ-L-glutamate and its nanofabrication2013

    • Author(s)
      M. Ashiuchi, K. Fukushima, H. Oya, T. Hiraoki, S. Shibatani, N. Oka, H. Nishimura, H. Hakuba, M. Nakamori, M. Kitagawa
    • Journal Title

      Appl. Mater. Interfaces

      Volume: 5 Issue: 5 Pages: 1619-1624

    • DOI

      10.1021/am3032025

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pivotal enzyme in glutamate metabolism of poly-γ-glutamate-producing microbes2013

    • Author(s)
      M. Ashiuchi, T. Yamamoto, T. Kamei
    • Journal Title

      Life

      Volume: 3 Issue: 1 Pages: 181-188

    • DOI

      10.3390/life3010181

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ポリ-γ-グルタミン酸の立体選択合成と化学改質2012

    • Author(s)
      芦内 誠
    • Journal Title

      科学と工業高分子

      Volume: 61 Pages: 773-774

    • NAID

      10031009348

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 好塩古細菌が生み出す天然系の親水性保湿剤の開発2012

    • Author(s)
      北川 優, 北澤宏明, 柳谷周作, 山本周平, 小松陽子, 松井まり子, 曽我部 敦, 芦内 誠
    • Journal Title

      科学と工業

      Volume: 86(5) Pages: 62-68

    • Related Report
      2012 Research-status Report
  • [Presentation] ポリ-γ-グルタミン酸の化学改質と金属親和性の改変2015

    • Author(s)
      芦内 誠、尾池翔太、白米優一
    • Organizer
      日本農芸化学会(年次大会)
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ポリγグルタミン酸超分子複合体の抗菌/抗ウイルス機能とその感染予防材料としての新たな可能性2015

    • Author(s)
      芦内 誠
    • Organizer
      日本ビタミン学会(ビタミンB研究協議会)
    • Place of Presentation
      キャンパスイノベーションセンター東京
    • Year and Date
      2015-02-06 – 2015-02-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] PGAIC, Novel Bio-Inspired Plastics with Anti-Infective, Wide-Applicable Coating Performance2014

    • Author(s)
      M. Ashiuchi, S. Oike, S. Shibatani, H. Hakuba, K. Yoneda
    • Organizer
      The 10th SPSJ Inter-national Polymer Conference (IPC2014)
    • Place of Presentation
      Tukuba International Congress Center
    • Year and Date
      2014-12-02 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 優れた抗感染性と表面被膜化能を備えたバイオプラスチック新素材“PGAIC”2014

    • Author(s)
      芦内 誠、尾池翔太、柴谷滋郎、白馬弘文、岡 秒歩、平田 諒
    • Organizer
      高分子討論会
    • Place of Presentation
      長崎大学
    • Year and Date
      2014-09-24 – 2014-09-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ポリ-γ-L-グルタミン酸イオンコンプレックス(PGAIC)の抗菌・抗ウイルス効果に関する研究2014

    • Author(s)
      白馬弘文、柴谷滋郎、芦内 誠
    • Organizer
      日本防菌防黴学会(年次大会)
    • Place of Presentation
      品川区立総合区民会館
    • Year and Date
      2014-09-24 – 2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] ポリ-γ-グルタミン酸とストロンチウムイオンによって強化される炭酸脱水酵素のバイオミネラリゼーション機能2014

    • Author(s)
      芦内 誠、島田哲弘、若松泰介
    • Organizer
      日本生物工学会(年次大会)
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2014-09-09 – 2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 好アルカリ性細菌Bacillus haloduransの推定L-ホモ型ポリ-γ-グルタミン酸合成システム2014

    • Author(s)
      芦内 誠
    • Organizer
      日本ビタミン学会(ビタミンB研究協議会)
    • Place of Presentation
      西長門リゾート
    • Year and Date
      2014-09-05 – 2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] -Glutamic Acid in Microbial Exo-Polymer, Poly-γ-Glutamate2014

    • Author(s)
      M. Ashiuchi
    • Organizer
      The 2nd International Conference of D-Amino Acid Research (IPC2014)
    • Place of Presentation
      Tochigi Prefectural Culture Center
    • Year and Date
      2014-09-02 – 2014-09-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Rapid Purification of D-Glutamate-Rich Bio-Nylon Polymer from Japanese Fermented Soybean Food "Natto" and Its Chemical Transformation into Antimicrobial Thermoplastics2014

    • Author(s)
      M. Ashiuchi, S. Oike, T. Wakamatsu
    • Organizer
      The 2nd International Conference of D-Amino Acid Research (IPC2014)
    • Place of Presentation
      Tochigi Prefectural Culture Center
    • Year and Date
      2014-09-02 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] ポリ-γ-グルタミン酸のバイオ合成と先端機能プラスチック化2014

    • Author(s)
      芦内 誠
    • Organizer
      日本農芸化学会(中四国支部/若手企画)
    • Place of Presentation
      岡山大学
    • Year and Date
      2014-05-16 – 2014-05-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ポリ-γ-グルタミン酸のバイオ合成と先端機能プラスチック化2014

    • Author(s)
      芦内 誠
    • Organizer
      日本農芸化学会(中四国支部/若手企画シンポジウム)
    • Place of Presentation
      岡山大学(岡山県)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ポリ-γ-グルタミン酸の合成と改質、並びに応用例について2013

    • Author(s)
      芦内 誠
    • Organizer
      日本農芸化学会(年次大会)
    • Place of Presentation
      明治大学(神奈川県)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 超好熱菌の2つのNAD(P)-グルタミン酸脱水素酵素の機能開発2013

    • Author(s)
      若松泰介、芦内 誠、土居克実、大島敏久
    • Organizer
      日本ビタミン学会(ビタミンB研究協議会)
    • Place of Presentation
      ウインクあいち(愛知県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Antimicrobial activity of a poly-γ-glutamate ioncomplex-based bioplasitic material2013

    • Author(s)
      Makoto Ashiuchi、Kenzo Fukushima、Haruna Oya、Shigeo Shibatani、Hirofumi Hakuba
    • Organizer
      日本生物工学会(年次大会)
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ポリ-γ-グルタミン酸イオンコンプレックスを基礎とする新規バイオプラスチック素材の抗菌性2013

    • Author(s)
      芦内 誠、福島賢三、大矢遥那、柴谷滋郎、白馬弘文
    • Organizer
      日本生物工学会(年次大会)
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Chemical transformation of stereo-regular poly-gamma-glutamate, giving self-healing hydrogels2013

    • Author(s)
      Makoto Ahiuchi, Shota Oike, Haruna Oya, Nogiho Oka, Kento Yamamoto, Kanae Senoo
    • Organizer
      日本生化学会(年次大会)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 立体規則性ポリ-γ-グルタミン酸を基礎とする自己修復性バイオゲルの開発2013

    • Author(s)
      芦内 誠、尾池翔太、大矢遥那、岡 秒歩、山本健人、妹尾香苗
    • Organizer
      日本生化学会(年次大会)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 枯草菌EdmS(PgsE)タンパク質はエピソームの維持に関与している2013

    • Author(s)
      白米優一、若松泰介、芦内 誠
    • Organizer
      日本農芸化学会(関西・中四国・西日本支部)および日本ビタミン学会(近畿・中国四国・九州沖縄地区)合同大会
    • Place of Presentation
      県立広島大学(広島県)
    • Related Report
      2013 Research-status Report
  • [Presentation] ポリ-γ-グルタミン酸の超分子(複合)材料化と新機能開発2013

    • Author(s)
      尾池翔太、妹尾香苗、若松泰介、芦内 誠
    • Organizer
      日本農芸化学会(関西・中四国・西日本支部)および日本ビタミン学会(近畿・中国四国・九州沖縄地区)合同大会
    • Place of Presentation
      県立広島大学(広島県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 好アルカリ性バシラスの推定L-ホモ型ポリ-γ-グルタミン酸合成酵素2013

    • Author(s)
      芦内 誠、山本 孝、清水一希、小松和也
    • Organizer
      日本農芸化学会(年次大会)
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2012 Research-status Report
  • [Presentation] バイオゲル新素材“ドーパミルポリ-γ-グルタミン酸”の環境調和合成とその反応メカニズム2013

    • Author(s)
      岡 秒歩、大矢遥那、山本健人、芦内 誠
    • Organizer
      日本農芸化学会(中四国支部例会)
    • Place of Presentation
      高知大学(高知県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Development and nanofabrication of antimicrobial thermoplastic material from archaeal poly-γ-L-glutamate2012

    • Author(s)
      Makoto Ahiuchi、Kenzo Fukushima、Haruna Oya、Toshihumi Hiraoki、Hirokazu Nishimura、Hirofumi Hakuba、Masahiko Nakamori、Masaru Kitagawa
    • Organizer
      日本生化学会(年次大会)
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 古細菌型ポリ-γ-グルタミン酸を基礎とする新規制菌プラスチック素材の開発とナノファイバー化2012

    • Author(s)
      芦内 誠、福島賢三、大矢遥那、平沖敏文、西村浩和、白馬弘文、中森雅彦、北川 優
    • Organizer
      日本生化学会(年次大会)
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Novel chemo-reforming of a water-soluble biopolymer, poly-γ-glutamate, giving self-healing superabsorbent materials2012

    • Author(s)
      Makoto Ashiuchi, Haruna Oya, Nogiho Oka, Ken-Ichi Sano, Toshifumi Hiraoki
    • Organizer
      The 9th SPSJ International Polymer Conference (IPC2012)
    • Place of Presentation
      Kobe International Conference Center (Kobe)
    • Related Report
      2012 Research-status Report
  • [Presentation] ポリ-γ-グルタミン酸の高性能ゲル化と金属イオン応答性2012

    • Author(s)
      山本健人、尾池翔太、大矢遥那、山崎紗千代、芦内 誠
    • Organizer
      日本生物工学会(年次大会)
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 納豆菌より見いだされた新奇染色体外DNA維持機構:ポリ-γ-グルタミン酸生合成因子PgsEと鞭毛形成因子FilFの必須性2012

    • Author(s)
      芦内 誠、山本健人、山城大典
    • Organizer
      日本農芸化学会(中四国支部大会)
    • Place of Presentation
      山口大学(山口県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 水溶性バイオポリマー“ポリ-γ-グルタミン酸”の高性能ゲル化2012

    • Author(s)
      芦内 誠、大矢遥那
    • Organizer
      高分子討論会
    • Place of Presentation
      名古屋工業大学(愛知県)
    • Related Report
      2012 Research-status Report
  • [Presentation] バイオミメティックゲル新素材“ドーパミルポリ-γ-グルタミン酸”の金属イオン吸着性2012

    • Author(s)
      尾池翔太、大矢遥那、山崎紗千代、芦内 誠
    • Organizer
      日本生物工学会(西日本支部大会)
    • Place of Presentation
      岡山大学(岡山県)
    • Related Report
      2012 Research-status Report
  • [Book] 環境と微生物の辞典(納豆菌の生態と利用)2014

    • Author(s)
      芦内 誠
    • Total Pages
      1
    • Publisher
      朝倉出版
    • Related Report
      2014 Annual Research Report
  • [Book] 環境と微生物の辞典(納豆菌と炭疽菌の違い)2014

    • Author(s)
      芦内 誠
    • Total Pages
      2
    • Publisher
      朝倉出版
    • Related Report
      2014 Annual Research Report
  • [Book] 環境と微生物の辞典(納豆菌の生態と利用)2014

    • Author(s)
      芦内 誠
    • Publisher
      朝倉出版(東京)
    • Related Report
      2013 Research-status Report
  • [Book] 環境と微生物の辞典(納豆菌と炭疽菌の違い)2014

    • Author(s)
      芦内 誠
    • Publisher
      朝倉出版(東京)
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] ポリ(メタ)アクリル酸イオンコンプレックス2015

    • Inventor(s)
      芦内 誠、妹尾香苗、白馬弘文、小林久人、柴谷滋郎、宝田 裕
    • Industrial Property Rights Holder
      芦内 誠、妹尾香苗、白馬弘文、小林久人、柴谷滋郎、宝田 裕
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-006941
    • Filing Date
      2015-01-16
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 耐水耐有機溶媒性組成物2015

    • Inventor(s)
      芦内 誠、白馬弘文、柴谷滋郎、小林久人
    • Industrial Property Rights Holder
      芦内 誠、白馬弘文、柴谷滋郎、小林久人
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-012087
    • Filing Date
      2015-01-26
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 芦内 誠、妹尾香苗、白馬弘文、小林久人、柴谷滋郎、宝田 裕2014

    • Inventor(s)
      芦内 誠、妹尾香苗、白馬弘文、小林久人、柴谷滋郎、宝田 裕
    • Industrial Property Rights Holder
      高知大学、東洋紡(株)
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-015341
    • Filing Date
      2014-01-30
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 抗真菌剤およびコーティング剤2013

    • Inventor(s)
      柴谷滋郎、中森雅彦、白馬弘文、宝田 裕、芦内 誠
    • Industrial Property Rights Holder
      高知大学、東洋紡(株)
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-165549
    • Filing Date
      2013-08-08
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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