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Noninvasive measurement of cell physical characteristics by terahertz waves

Research Project

Project/Area Number 24656085
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Materials/Mechanics of materials
Research InstitutionNagoya University

Principal Investigator

JU Yang  名古屋大学, 工学(系)研究科(研究院), 教授 (60312609)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords細胞 / テラヘルツ波 / 非侵襲計測 / 誘電率
Research Abstract

In this research, the noninvasive measurement of cells to determine their physical characteristics with an engineering approach was carried out. The propertied of terahertz wave spectrum which has a relationship with the plasma frequency and electron scattering time were utilized, and the carrier density, mobility, conductivity and permittivity of the intracellular material of cells were measured based on the transmission effect of terahertz wave spectrum. A method to determine the physical characteristics of cells was established. By evaluating the electrical properties of living cells it is possible to realize the real time and noninvasive discrimination of cell types and identification of cell functions.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (38 results)

All 2014 2013 2012 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (25 results) Remarks (1 results)

  • [Journal Article] Surface Functionalization of Nanoporous Alumina with Bone Morphogenetic Protein 2 for Inducing Osteogenic Differentiation of Mesenchymal Stem Cells2014

    • Author(s)
      Y.Song, Y.Ju, Y.Morita, B.Xu, G.Song
    • Journal Title

      Materials Science & Engineering C

      Volume: 37 Pages: 120-126

    • DOI

      10.1016/j.msec.2014.01.004

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences between protein expression and extracellular matrix state on uniaxial stretching for tenogenic differentiation2014

    • Author(s)
      Y.Morita, S.Suzuki, Y.Ju, N.Kawase
    • Journal Title

      Journal of Mechanics in Medicine and Biology

      Volume: 14 Issue: 02 Pages: 1450025-1450025

    • DOI

      10.1142/s0219519414500250

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] synthetic mechano-growth factor E peptide promotes rat tenocyte migration by lessening cell stiffness and increasing F-actin formation via the FAK-ERK1/2 signaling pathway2014

    • Author(s)
      B.Zhang, Q.Luo, X.Mao, B.Xu, L.Yang, Y.Ju, G Song
    • Journal Title

      Experimental Cell Research

      Volume: 322 Issue: 1 Pages: 208-216

    • DOI

      10.1016/j.yexcr.2014.01.005

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] tLyP-1-conjugated mesoporous silica nanoparticles for tumor targeting and penetrating hydrophobic drug delivery2013

    • Author(s)
      B.Xu, Y.Ju, G.Song and Y.Cui
    • Journal Title

      Journal of Nanoparticle Research

      Volume: 15 Issue: 12

    • DOI

      10.1007/s11051-013-2105-4

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro experimental study for the determination of cellular axial strain threshold and preferential axial strain from cell orientation behavior in a non-uniform deformation field2013

    • Author(s)
      Y.Morita, S.Watanabe, Y.Ju, and S.Yamamoto
    • Journal Title

      Cell Biochemistry and Biophysics

      Volume: 67 Issue: 3 Pages: 1249-1259

    • DOI

      10.1007/s12013-013-9643-3

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro proliferation and osteogenic differentiation of mesenchymal stem cells on nanoporous alumina2013

    • Author(s)
      Y. Song, Y. Ju, G. Song and Y. Morita
    • Journal Title

      International Journal of Nanomedicine

      Volume: 8 Pages: 2745-2756

    • DOI

      10.2147/ijn.s44885

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determination of optimal cyclic uniaxial stretches for stem cell-to-tenocyte differentiation under a wide range of mechanical stretch conditions by evaluating gene expression and protein synthesis levels2013

    • Author(s)
      Y. Morita, S. Watanabe, Y. Ju, and B. Xu
    • Journal Title

      Acta of Bioengineering and Biomechanics

      Volume: 15 Pages: 71-79

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of the Nanostructure of Porous Alumina on Growth Behavior of MG63 Osteoblast-like Cells2013

    • Author(s)
      Y.Song, Y.Ju, Y.Morita, G.Song
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 116 Issue: 4 Pages: 509-515

    • DOI

      10.1016/j.jbiosc.2013.04.007

    • NAID

      110009675469

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Cell-to-Tenocyte Differentiation By Atomic Force Microscopy to Measure Cellular Elastic Modul2013

    • Author(s)
      Y.Morita, T.Mukai and Y.Ju and S.Watanabe
    • Journal Title

      Cell Biochemistry and Biophysics

      Volume: 66 Issue: 1 Pages: 73-80

    • DOI

      10.1007/s12013-012-9455-x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fabrication of Cu nanowires and its effect on proliferation of mesenchymal stem cells2013

    • Author(s)
      Y. Song, Y. Ju, L. Zhang, Y. Morita and G. Song
    • Journal Title

      Materials Science Forum

      Volume: 750 Pages: 56-59

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanical stretch-induced f-actin reorganization and tenogenic differentiation of human mesenchymal stem cells2012

    • Author(s)
      B. Xu, Y. Ju and G. Song
    • Journal Title

      Journal of Biological Research-Thessaloniki

      Volume: 18 Pages: 218-226

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] RhoA/ROCK, Cytoskeletal Dynamics, and Focal Adhesion Kinase are Required for Mechanical Stretch-Induced Tenogenic Differentiation of Human Mesenchymal Stem Cells2012

    • Author(s)
      B. Xu, G. Song, Y. Ju, X. Li, Y. Song and S. Watanabe
    • Journal Title

      Journal of Cellular Physiology

      Volume: 227 Issue: 6 Pages: 2722-2729

    • DOI

      10.1002/jcp.23016

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 細胞外マトリックスの力学場計測の実現に向けたDVC法の開発2013

    • Author(s)
      森田康之, 河瀬直樹, 巨陽
    • Organizer
      日本非破壊検査協会平成25年第2回応力・ひずみ測定部門講演会
    • Place of Presentation
      金沢大学(石川県)
    • Year and Date
      2013-11-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Experimental study for the relationship between cell differentiation and mechanical strain using a non-uniform deformation field2013

    • Author(s)
      Yasuyuki Morita, Toshihiro Sato and Yang Ju
    • Organizer
      The 8th International Symposium on Advanced Science and Technology in Experimental Mechanics (8th ISEM'13-Sendai)
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2013-11-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞周辺の力学場計測の実現に向けたDVC法の開発2013

    • Author(s)
      河瀬直樹, 森田康之, 巨陽
    • Organizer
      M&M2013カンファレンス
    • Place of Presentation
      岐阜大学(岐阜県)
    • Year and Date
      2013-10-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨髄幹細胞と軟骨細胞の細胞間相互作用による接触共培養系の開発2013

    • Author(s)
      山本周平, 森田康之, 巨陽
    • Organizer
      日本機械学会2013年度年次大会
    • Place of Presentation
      岡山大学(岡山県)
    • Year and Date
      2013-09-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 配向を制御した間葉系幹細胞の伸縮培養による腱細胞への分化および評価に関する研究2013

    • Author(s)
      森田康之, 鈴木敏, 巨陽
    • Organizer
      日本実験力学会2013年度年次講演会
    • Place of Presentation
      由利本荘市文化交流館(秋田県)
    • Year and Date
      2013-08-22
    • Related Report
      2013 Final Research Report
  • [Presentation] テラヘルツ電磁波による生細胞の誘電率の定量評価2013

    • Author(s)
      足土広祐, 森田康之, 鈴木敏, 徐百耀, 山本周平, 巨陽
    • Organizer
      日本機械学会東海支部第62期総会講演会
    • Place of Presentation
      三重大学(三重県)
    • Year and Date
      2013-03-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 非一様ひずみ環境下での伸縮刺激における間葉系幹細胞の腱細胞への分化特性2013

    • Author(s)
      佐藤俊博, 森田康之, 巨陽
    • Organizer
      日本機械学会東海支部学生会第44回学生員卒業研究発表講演会
    • Place of Presentation
      三重大学(三重県)
    • Year and Date
      2013-03-17
    • Related Report
      2013 Final Research Report
  • [Presentation] デジタル画像相関法を用いた基板の変形計測による幹細胞の接着性評価に関する研究2013

    • Author(s)
      河瀬直樹, 森田康之, 巨陽
    • Organizer
      日本機械学会東海支部学生会第44回学生員卒業研究発表講演会
    • Place of Presentation
      三重大学(三重県)
    • Year and Date
      2013-03-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 配向を制御した間葉系幹細胞の伸縮培養による腱細胞への分化および評価に関する研究2013

    • Author(s)
      森田康之,鈴木敏,巨陽
    • Organizer
      日本実験力学会2013年度年次講演会
    • Place of Presentation
      秋田県由利本荘市 由利本荘市文化交流館「カダーレ」
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨髄幹細胞と軟骨細胞の細胞間相互作用による接触共培養系の開発2013

    • Author(s)
      山本 周平,森田 康,巨 陽
    • Organizer
      日本機械学会2013年度年次大会
    • Place of Presentation
      岡山県岡山市 岡山大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞周辺の力学場計測の実現に向けたDVC法の開発2013

    • Author(s)
      河瀬 直樹,森田 康之,巨 陽
    • Organizer
      M&M2013カンファレンス
    • Place of Presentation
      岐阜県岐阜市 岐阜大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Experimental study for the relationship between cell differentiation and mechanical strain using a non-uniform deformation field2013

    • Author(s)
      Yasuyuki Morita, Toshihiro Sato and Yang Ju
    • Organizer
      The 8th International Symposium on Advanced Science and Technology in Experimental Mechanics (8th ISEM’13-Sendai)
    • Place of Presentation
      宮城県仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 配向を制御した間葉系幹細胞の伸縮培養による腱細胞分化に関する研究2012

    • Author(s)
      鈴木敏, 森田康之, 巨陽
    • Organizer
      第23回バイオフロンティア講演会
    • Place of Presentation
      弘前文化センター(青森県)
    • Year and Date
      2012-10-06
    • Related Report
      2013 Final Research Report
  • [Presentation] ひずみ勾配を有する伸縮刺激下での間葉系幹細胞の配向・分化特性解析に関する研究2012

    • Author(s)
      森田康之, 渡邉早智, 巨陽
    • Organizer
      日本機械学会M&M2012材料力学カンファレンス
    • Place of Presentation
      愛媛大学(愛媛県)
    • Year and Date
      2012-09-23
    • Related Report
      2013 Final Research Report
  • [Presentation] ひずみ勾配を有する伸縮刺激下での幹細胞の動態解析に関する研究2012

    • Author(s)
      森田康之, 渡邉早智, 巨陽
    • Organizer
      日本実験力学会2012年度年次講演会
    • Place of Presentation
      豊橋技術科学大学(愛知県)
    • Year and Date
      2012-07-15
    • Related Report
      2013 Final Research Report
  • [Presentation] ひずみ勾配を有する伸縮刺激下での間葉系幹細胞の配向挙動に関する研究2012

    • Author(s)
      森田康之, 渡邉早智, 巨陽
    • Organizer
      日本実験力学会The 11th Conference on Biomechanics in Niigata
    • Place of Presentation
      新潟大学(新潟県)
    • Year and Date
      2012-04-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞外マトリックスの力学場計測の実現に向けたDVC法の開発

    • Author(s)
      森田康之,河瀬直樹,巨陽
    • Organizer
      日本非破壊検査協会平成25年第2回応力・ひずみ測定部門講演会
    • Place of Presentation
      石川県金沢市 金沢大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 間葉系幹細胞の整列伸縮培養による腱細胞への効率的分化促進に関する研究

    • Author(s)
      山村直也, 佐藤俊博, 山本周平, 市岡和馬, 森田 康之, 巨 陽
    • Organizer
      日本機械学会東海支部 東海学生会第45回学生員卒業研究発表講演会
    • Place of Presentation
      愛知県名古屋市 大同大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] ひずみ勾配を有する伸縮刺激下での間葉系幹細胞の配向挙動に関する研究

    • Author(s)
      森田康之,渡邉早智,巨陽
    • Organizer
      日本実験力学会 The 11th Conference on Biomechanics in Sendai
    • Place of Presentation
      新潟大学,新潟県新潟市
    • Related Report
      2012 Research-status Report
  • [Presentation] ひずみ勾配を有する伸縮刺激下での幹細胞の動態解析に関する研究

    • Author(s)
      森田康之,渡邉早智,巨陽
    • Organizer
      日本実験力学会2012年度年次講演会
    • Place of Presentation
      豊橋技術科学大学,愛知県豊橋市
    • Related Report
      2012 Research-status Report
  • [Presentation] ひずみ勾配を有する伸縮刺激下での間葉系幹細胞の配向・分化特性解析に関する研究

    • Author(s)
      森田康之,渡邉早智,巨陽
    • Organizer
      日本機械学会 M&M2012材料力学カンファレンス
    • Place of Presentation
      愛媛大学 城北地区キャンパス,愛媛県松山市
    • Related Report
      2012 Research-status Report
  • [Presentation] 配向を制御した間葉系幹細胞の伸縮培養による腱細胞分化に関する研究

    • Author(s)
      鈴木敏,森田康之,巨陽
    • Organizer
      第23回バイオフロンティア講演会
    • Place of Presentation
      青森県 弘前市 弘前文化センター
    • Related Report
      2012 Research-status Report
  • [Presentation] デジタル画像相関法を用いた基板の変形計測による幹細胞の接着性評価に関する研究

    • Author(s)
      河瀬直樹,森田康之,巨陽
    • Organizer
      日本機械学会東海支部学生会第44回学生員卒業研究発表講演会
    • Place of Presentation
      三重県 津市 三重大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 非一様ひずみ環境下での伸縮刺激における間葉系幹細胞の腱細胞への分化特性

    • Author(s)
      佐藤俊博,森田康之,巨陽
    • Organizer
      日本機械学会東海支部学生会第44回学生員卒業研究発表講演会
    • Place of Presentation
      三重県 津市 三重大学
    • Related Report
      2012 Research-status Report
  • [Presentation] テラヘルツ電磁波による生細胞の誘電率の定量評価

    • Author(s)
      足土広祐,森田康之,鈴木敏,徐百耀,山本周平,巨陽
    • Organizer
      日本機械学会東海支部第62期総会講演会
    • Place of Presentation
      三重県 津市 三重大学
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.mech.nagoya-u.ac.jp/ju/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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