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Study on ultra-precision viscosity measurement using a fluorescent probe

Research Project

Project/Area Number 24656088
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Materials/Mechanics of materials
Research InstitutionOsaka University

Principal Investigator

HAYASHI Terutake  大阪大学, 工学(系)研究科(研究院), 准教授 (00334011)

Co-Investigator(Kenkyū-buntansha) TAKAYA Yasuhiro  大阪大学, 大学院工学研究科, 教授 (70243178)
MICHIHATA Masaki  大阪大学, 大学院工学研究科, 助教 (70588855)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords蛍光偏光法 / ブラウン運動 / 回転拡散係数 / 回転ブラウン運動 / ナノ粒子 / 粘性計測 / 偏光解消 / デバイストークスアインシュタインの法則
Research Abstract

In this study, we suggest a novel method for evaluating the viscosity of small samples based on the rotational diffusion coefficient of the nano probe by using fluorescence polarization method. In the case of using the fluorescence probe with lifetime less than 10 ns ( i.e. Fluorescein, fluorescence lifetime 4.3ns, diameter 1.1nm) , it is possible to accelerate the rate of fluorescence polarization analysis for viscosity measurement to 100MHz. Furthermore, by using the probe with diameter of 1nm, the measurement accuracy of the viscosity using a diffusion model of the Brownian motion is improved due to minimizing the influence of the inertial force of probe.
As a result, we construct the fundamental system to evaluate the rotational diffusion coefficient for small sample. We verify the feasibility of proposed method for evaluating the viscosity of small sample based on the rotational diffusion coefficient.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (7 results)

  • [Journal Article] 蛍光偏光法を用いたナノ粒子粒径計測に関する研究(第1報)-蛍光DNAプローブを用いた回転拡散係数測定システムの開発-2014

    • Author(s)
      石崎佑樹,林照剛,道畑正岐,高谷裕浩
    • Journal Title

      精密工学会誌

      Volume: VOl.80, No.3 Pages: 214-219

    • NAID

      130003394534

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 蛍光偏光法を用いたナノ粒子粒径計測に関する研究(第1報)-蛍光DNAプローブを用いた回転拡散係数測定システムの開発-2014

    • Author(s)
      石崎佑樹,林 照剛,道畑正岐,高谷裕浩
    • Journal Title

      精密工学会誌

      Volume: 2 Pages: 214-219

    • NAID

      130003394534

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of nanoparticle sizing system using fluorescence polarization2013

    • Author(s)
      Terutake Hayashi, Masaki Michihata, Yasuhiro Takaya, and Kok Fonog Lee
    • Journal Title

      ACTA IMEKO

      Volume: Vol. 2, No. 2 Pages: 67-72

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of nanoparticle sizing system integrated with optical microscopy using fluorescence polarization2012

    • Author(s)
      Terutake Hayashi, Yasuhiro Takaya and Masaki Michihata
    • Journal Title

      International Journal of Nanomanufacturing

      Volume: Vol. 8, Nos. 1/2 Pages: 54-56

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 周波数領域蛍光法を用いたナノ粒子粒径評価に関する研究(第二報)-粒径と蛍光DNAプローブの回転拡散係数の関係性についての検討-2014

    • Author(s)
      石崎佑樹,林照剛,道畑正岐,高谷裕浩
    • Organizer
      2014年度精密工学会学術講演会春季大会
    • Place of Presentation
      東京大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 周波数領域蛍光法を用いたナノ粒子粒径評価に関する研究(第3報)-DNAを用いたナノ粒子計測プローブの開発-2014

    • Author(s)
      林照剛,石崎佑樹,道畑正岐,高谷裕浩,田中慎一
    • Organizer
      2014年度精密工学会学術講演会春季大会
    • Place of Presentation
      東京大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 周波数領域蛍光法を用いたナノ粒子粒径評価に関する研究(第3 報) -DNA を用いたナノ粒子計測プローブの開発-2014

    • Author(s)
      林 照剛,石崎佑樹,道畑正岐,高谷裕浩,田中慎一
    • Organizer
      2014年度精密工学会春期全国大会
    • Place of Presentation
      東京大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 周波数領域蛍光法を用いたナノ粒子粒径評価に関する研究(第二報) -粒径と蛍光DNAプローブの回転拡散係数の関係性についての検討-2014

    • Author(s)
      石崎佑樹,林照剛,道畑正岐,高谷裕浩
    • Organizer
      2014年度精密工学会春期全国大会
    • Place of Presentation
      東京大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of nanoparticles sizing method based on fluorescence polarization2013

    • Author(s)
      Yuki Ishizaki,Terutake Hayashi, Masaki Michihata, Yasuhiro Takaya
    • Organizer
      ISMQC2013
    • Place of Presentation
      University, Cracow, Poland (Best paper award)
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of nanoparticles sizing method based on fluorescence polarization2013

    • Author(s)
      Yuki Ishizaki, Terutake Hayashi, Masaki Michihata, Yasuhiro Takaya
    • Organizer
      ISMQC2013
    • Place of Presentation
      University, Cracow, Poland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of Nano Particle Sizing System Using Fluorescence Polarization2012

    • Author(s)
      Terutake Hayashi, Masaki Michihata, Yasuhiro Takaya, and Kok Foong Lee
    • Organizer
      XX IMEKO World Congress Metrology for Green Growth
    • Place of Presentation
      Busan, Korea
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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