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Development of a Taylor vortex flow bioreactor which is suitable for the cultivation and mixing of animal cells such as the undifferentiated cells easily destroyed in a shearing flow region

Research Project

Project/Area Number 24656116
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Fluid engineering
Research InstitutionMuroran Institute of Technology

Principal Investigator

KAWAI Hideki  室蘭工業大学, 工学(系)研究科(研究院), 教授 (20292071)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsTaylor渦 / 固気液分離 / カオス / 混相流 / 微生物流動 / 超音波ドップラ流速計 / Taylor渦 / 固液分離
Research Abstract

Bioreactors are one of the practical applications for an Taylor Vortex Flow system(TVF) which enables a milder mixing process protecting the animal cell like an indifferent cell from the damage of higher share flows. The TVF system with a small aspect ratio has characteristics of spectrum chaotic complicated flow with an Ekman boundary layer near the upper and lower boundaries.
In the present, we study the mixing effect of the TVF on uniformizing the immobilization of microorganism to the carriers. As the results, the distribution of the immobilization rate to the Bio supported polymers(BSPs) is much uniform with using the TVF bioreactor system compared with the previous aeration mixing method which is often used in the bio-mixing process. On the contrary, the immobilized absolute rate is much more in the aeration method, which is the current problem of the TVF system.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (45 results)

All 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (42 results) (of which Invited: 1 results)

  • [Journal Article] 小型冷間模型内に形成したレースウェイのX 線CT による三次元構造測定2014

    • Author(s)
      埜上洋,河合秀樹,八木順一郎
    • Journal Title

      鉄と鋼

      Volume: vol.100 Pages: 148-153

    • NAID

      130003395114

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of Three-Dimensional Raceway Structure in Small Scale Cold Model by X-ray Computed Tomography2014

    • Author(s)
      埜上洋,河合秀樹,八木順一郎
    • Journal Title

      Tetsu-to-Hagane

      Volume: 100 Issue: 2 Pages: 256-261

    • DOI

      10.2355/tetsutohagane.100.256

    • NAID

      130003395114

    • ISSN
      0021-1575, 1883-2954
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crack Propagation and Remaining Life Assessment of Coke Drums Due to Thermal Stresses2012

    • Author(s)
      H. Ambarita, M. Daimaruya, H. Fujiki, H. Kawai, H. Kobayashi and M. Oka
    • Journal Title

      Journal of Thermal Stresses

      Volume: vol.35 Pages: 1095-1107

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 充填層内流れの圧力逆転現象2014

    • Author(s)
      鎌田宗幸,河合秀樹,鈴木淳,熊谷建次,埜上 洋
    • Organizer
      日本鉄鋼協会第167回春季講演大会
    • Place of Presentation
      東京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Taylor 渦バイオリアクターにおける光合成微生物の増殖と藻体破壊2014

    • Author(s)
      小林裕平,河合秀樹
    • Organizer
      第23回化学工学・粉体工学研究発表会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Final Research Report
  • [Presentation] 低アスペクト比Taylor 渦の混相流における超音波計測技術2014

    • Author(s)
      三好宗幸,河合秀樹, 村川英樹,木倉宏成
    • Organizer
      第23回化学工学・粉体工学研究発表会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Final Research Report
  • [Presentation] バイオディーゼル燃料の粘度物性とGC による精油過程の評価2014

    • Author(s)
      三木千純,河合秀樹
    • Organizer
      第23回化学工学・粉体工学研究発表会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Final Research Report
  • [Presentation] 充填層内流れの圧力逆転現象2014

    • Author(s)
      鎌田宗幸,河合秀樹,鈴木淳,熊谷建次,埜上 洋
    • Organizer
      日本鉄鋼協会第167回春季講演大会
    • Place of Presentation
      東工大(東京都目黒区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] バイオディーゼル燃料の粘度物性とGCによる精油過程の評価2014

    • Author(s)
      三木千純,河合秀樹
    • Organizer
      第23回化学工学・粉体工学研究発表会
    • Place of Presentation
      北大(北海道札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 低アスペクト比Taylor渦の混相流における超音波計測技術2014

    • Author(s)
      三好宗幸,河合秀樹, 村川英樹,木倉宏成
    • Organizer
      第23回化学工学・粉体工学研究発表会
    • Place of Presentation
      北大(北海道札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Taylor渦バイオリアクターにおける光合成微生物の増殖と藻体破壊2014

    • Author(s)
      小林裕平,河合秀樹
    • Organizer
      第23回化学工学・粉体工学研究発表会
    • Place of Presentation
      北大(北海道札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 電磁流体の有限要素法による熱流体解析と実験2013

    • Author(s)
      河合秀樹,菅佑介
    • Organizer
      日本機械学会北海道支部第52回講演会
    • Place of Presentation
      函館市
    • Year and Date
      2013-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 超音波計測による低アスペクト比Taylor 渦の流動解析2013

    • Author(s)
      山田雄大,河合秀樹
    • Organizer
      日本機械学会北海道支部第52回講演会
    • Place of Presentation
      函館市
    • Year and Date
      2013-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 高レイノルズ数Taylor 渦の数値シミュレーション2013

    • Author(s)
      赤沢悠太,河合秀樹
    • Organizer
      日本機械学会北海道支部第52回講演会
    • Place of Presentation
      函館市
    • Year and Date
      2013-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Flow Instability of a Taylor Vortex Flow for Application of Bio-reactor Systems2013

    • Author(s)
      Hideki Kawai
    • Organizer
      Joint Symposium on Mechanical-Industrial Engineering and Robotics
    • Place of Presentation
      Chiang Mai
    • Related Report
      2013 Final Research Report
  • [Presentation] Numerical Analysis of a Taylor-Couette Vortex Flow at High Reynolds number2013

    • Author(s)
      Yuta Akazawa and Hideki Kawai
    • Organizer
      Joint Symposium on Mechanical-Industrial Engineering and Robotics
    • Place of Presentation
      Chiang Mai
    • Related Report
      2013 Final Research Report
  • [Presentation]2013

    • Author(s)
      Hiroki Fukui, Tsuyoshi Suzuki, Yuji Nikaido, Kyouhei Yumiba, Jun Suzuki, Hiroshi Nogami and Hideki Kawai
    • Organizer
      Joint Symposium on Mechanical-Industrial Engineering and Robotics
    • Place of Presentation
      Chiang Mai
    • Related Report
      2013 Final Research Report
  • [Presentation]2013

    • Author(s)
      Masahiro Fukuda, Jun Suzuki, Hiroshi Nogami and Hideki Kawai
    • Organizer
      Joint Symposium on Mechanical-Industrial Engineering and Robotics
    • Place of Presentation
      Chiang Mai.
    • Related Report
      2013 Final Research Report
  • [Presentation] 超音波速度計測によるアスペクト比の小さいTaylor 渦流れの流動解析2013

    • Author(s)
      河合秀樹,三好宗幸,木倉宏成,村川英樹
    • Organizer
      第91 期日本機械学会流体工学部門講演会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] 粗粒子で構成されたオリフィスの粉体粒子通過挙動のDEM 解析2013

    • Author(s)
      福田雅裕, 埜上洋, 河合秀樹
    • Organizer
      日本鉄鋼協会第166回秋季講演大会
    • Place of Presentation
      金沢市
    • Related Report
      2013 Final Research Report
  • [Presentation] Taylor-Couette 渦流れの超音波計測法について2013

    • Author(s)
      河合秀樹, 三好宗幸, 木倉宏成
    • Organizer
      第45回化学工学会秋季大会
    • Place of Presentation
      岡山市
    • Related Report
      2013 Final Research Report
  • [Presentation] Taylor-Couette 渦バイオリアクターにおける光合成微生物の増殖特性2013

    • Author(s)
      岡部紫苑,河合秀樹,山地秀樹,中村恵龍
    • Organizer
      第45回化学工学会秋季大会
    • Place of Presentation
      岡山市
    • Related Report
      2013 Final Research Report
  • [Presentation] 超音波計測によるアスペクト比の小さいTaylor 渦流れの流動解析2013

    • Author(s)
      三好宗幸,河合秀樹,村川英樹,木倉宏成
    • Organizer
      第41回可視化情報シンポジウム
    • Place of Presentation
      東京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Flow Instability of a Taylor Vortex Flow for Application of Bio-reactor Systems2013

    • Author(s)
      Hideki Kawai
    • Organizer
      Joint Symposium on Mechanical-Industrial Engineering and Robotics
    • Place of Presentation
      Centara Duangtawan Hotel, Chiang Mai, Thailand
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 粗粒子で構成されたオリフィスの粉体粒子通過挙動のDEM解析2013

    • Author(s)
      福田雅裕, 埜上洋, 河合秀樹
    • Organizer
      日本鉄鋼協会第166回秋季講演大会
    • Place of Presentation
      金沢大学(石川県金沢市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Numerical Analysis of a Taylor-Couette Vortex Flow at High Reynolds number2013

    • Author(s)
      Yuta Akazawa and Hideki Kawai
    • Organizer
      Joint Symposium on Mechanical-Industrial Engineering and Robotics
    • Place of Presentation
      Centara Duangtawan Hotel, Chiang Mai, Thailand
    • Related Report
      2013 Annual Research Report
  • [Presentation] Hydrothermal Decomposition of Polyvinyl Chloride and Its Observation2013

    • Author(s)
      Hiroki Fukui, Tsuyoshi Suzuki, Yuji Nikaido, Kyouhei Yumiba, Jun Suzuki, Hiroshi Nogami and Hideki Kawai
    • Organizer
      Joint Symposium on Mechanical-Industrial Engineering and Robotics
    • Place of Presentation
      Centara Duangtawan Hotel, Chiang Mai, Thailand
    • Related Report
      2013 Annual Research Report
  • [Presentation] DEM analysis on powder behavior passing through an orifice that consists of coarse particles2013

    • Author(s)
      Masahiro Fukuda, Jun Suzuki, Hiroshi Nogami and Hideki Kawai
    • Organizer
      Joint Symposium on Mechanical-Industrial Engineering and Robotics
    • Place of Presentation
      Centara Duangtawan Hotel, Chiang Mai, Thailand
    • Related Report
      2013 Annual Research Report
  • [Presentation] Taylor-Couette渦バイオリアクターにおける光合成微生物の増殖特性2013

    • Author(s)
      岡部紫苑,河合秀樹,山地秀樹,中村 恵龍
    • Organizer
      第45回化学工学会秋季大会
    • Place of Presentation
      岡山大学(岡山県岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Taylor-Couette渦流れの超音波計測法について2013

    • Author(s)
      河合秀樹,三好宗幸,木倉宏成
    • Organizer
      第45回化学工学会秋季大会
    • Place of Presentation
      岡山大学(岡山県岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 超音波速度計測によるアスペクト比の小さいTaylor渦流れの流動解析2013

    • Author(s)
      河合秀樹,三好宗幸,木倉宏成,村川英樹
    • Organizer
      第91期日本機械学会流体工学部門講演会
    • Place of Presentation
      九州大学(福岡県福岡市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 超音波計測によるアスペクト比の小さいTaylor渦流れの流動解析2013

    • Author(s)
      三好宗幸,河合秀樹,村川英樹,木倉宏成
    • Organizer
      第41回可視化情報シンポジウム
    • Place of Presentation
      工学院大学(東京都新宿区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Taylor-Couette 渦バイオリアクターにおける光合成微生物の増殖と藻体破壊について2012

    • Author(s)
      小林裕平,河合秀樹,山地秀樹,中村恵龍
    • Organizer
      化学工学会 第44回秋季大会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Final Research Report
  • [Presentation] 低アスペクト比Taylor 渦の超音波速度計測法について2012

    • Author(s)
      河合秀樹,三好宗幸,埜上洋,木倉宏成
    • Organizer
      化学工学会 第44回秋季大会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Final Research Report
  • [Presentation] Numerical Flow Analysis of Electromagnetic Fluid Using GSMAC Finite-Element Method2012

    • Author(s)
      Kun YANG, Yoshitaka SAITOH, Hideki KAWAI, Nobuyoshi TSUZUKI, Hiroshige KIKURA and Gaku HASHIMOTO
    • Organizer
      Proceeding of the 20th International Conference on Nuclear Engineering(ICONE20)
    • Place of Presentation
      Anaheim
    • Related Report
      2013 Final Research Report
  • [Presentation] 超音波計測によるアスペクト比の小さいTaylor渦流れの流動解析2012

    • Author(s)
      河合秀樹,三好宗幸,木倉宏成
    • Organizer
      第40回可視化情報シンポジウム
    • Place of Presentation
      東京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 有限要素法による溶融ガラス模擬流体流動シミュレーション2012

    • Author(s)
      木倉宏成,都築宣嘉,川口達也,河合秀樹,南和宏,越智英治
    • Organizer
      第24回電磁力関連のダイナミクスシンポジウム
    • Place of Presentation
      富山市
    • Related Report
      2013 Final Research Report
  • [Presentation] 有限要素法による溶融ガラス模擬流体流動シミュレーション2012

    • Author(s)
      木倉宏成,都築宣嘉,川口達也,河合秀樹,南和宏,越智英治
    • Organizer
      第24回「電磁力関連のダイナミクス」シンポジウム
    • Place of Presentation
      富山
    • Related Report
      2012 Research-status Report
  • [Presentation] 超音波計測によるアスペクト比の小さいTaylor渦流れの流動解析2012

    • Author(s)
      河合秀樹,三好宗幸,木倉宏成
    • Organizer
      第40回可視化情報シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 低アスペクト比Taylor渦の超音波速度計測法について2012

    • Author(s)
      河合 秀樹 , 三好 宗幸,埜上 洋 ,木倉 宏成
    • Organizer
      化学工学会 第44回秋季大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] Taylor-Couette渦バイオリアクターにおける光合成微生物の増殖と藻体破壊について2012

    • Author(s)
      小林 裕平,河合 秀樹,山地 秀樹,中村 恵龍
    • Organizer
      化学工学会 第44回秋季大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] Numerical Flow Analysis of Electromagnetic Fluid Using GSMAC Finite-Element Method2012

    • Author(s)
      Kun YANG, Yoshitaka SAITOH, Hideki KAWAI, Nobuyoshi TSUZUKI, Hiroshige KIKURA and Gaku HASHIMOTO
    • Organizer
      The 20th International Conference on Nuclear Engineering (ICONE20)
    • Place of Presentation
      Anaheim, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 高レイノルズ数Taylor渦の数値シミュレーション

    • Author(s)
      赤沢悠太,河合秀樹
    • Organizer
      日本機械学会北海道支部第52回講演会
    • Place of Presentation
      函館高専(北海道函館市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 超音波計測による低アスペクト比Taylor渦の流動解析

    • Author(s)
      山田雄大,河合秀樹
    • Organizer
      日本機械学会北海道支部第52回講演会
    • Place of Presentation
      函館高専(北海道函館市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 電磁流体の有限要素法による熱流体解析と実験

    • Author(s)
      河合秀樹,菅佑介
    • Organizer
      日本機械学会北海道支部第52回講演会
    • Place of Presentation
      函館高専(北海道函館市)
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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