• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Three-dimensional neuronal networking for regenerative medicine by active utilization of three-dimensional dynamic stimulation field

Research Project

Project/Area Number 24656150
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dynamics/Control
Research InstitutionYamagata University

Principal Investigator

KOSAWADA Tadashi  山形大学, 理工学研究科, 教授 (10143083)

Co-Investigator(Renkei-kenkyūsha) FENG Zhonggang  山形大学, 理工学研究科, 准教授 (10332545)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords動的力学刺激 / 3次元振動ステージ / iPS細胞 / ポリ乳酸多孔質体 / 分化誘導 / 3次元ニューロンネットワーク / 再生治療 / 3次元振動ステージ / i PS細胞 / ニューロンネットワーク / ポリ乳酸多孔体足場
Outline of Final Research Achievements

We have developed completely new small sized piezoelectric three-dimensional vibration stage. Together with scaffold of poly-lactic acid, the device enables us to enforce various micro dynamic stimulations upon the cultured living cells.
The system, not like a conventional approach but based on the principle of mechanics, has an ability to support development of the regenerative medicine by using iPS cells. The results suggest that utilization of appropriate dynamic stimulation may accelerate three-dimensional neuronal networking. It is also found that there may be certain correlation between the direction of the neuronal networking and the direction of the dynamic stimulation.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (19 results)

All 2014 2013 2012 Other

All Journal Article (5 results) (of which Acknowledgement Compliant: 2 results,  Peer Reviewed: 4 results) Presentation (13 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] 動的力学刺激によるヒトiPS細胞の培養・分化制御法2014

    • Author(s)
      小沢田 正
    • Journal Title

      ≪最新≫動物細胞培養の手法と細胞死・増殖不良・細胞変異を防止する技術

      Volume: 2-5-1 Pages: 270-275

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Novel Method to Explore the Mechanical Inhomogeneity of Human Osteoblast Nucleus and Its Relationship to Cell Cycle2014

    • Author(s)
      T Kosawada, R Harada, R Ajiki, H Endo, Z Feng
    • Journal Title

      Proceedings of the JSME/ASME 2014 International Conference on Materials and Processing

      Volume: 1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Analysis of the Contraction of Fibroblast-Collagen Gels and the Traction Force of Individual Cells by a Novel Elementary Structural Model2013

    • Author(s)
      Z. Feng, Y. Wagatsuma, S. Kobayashi, T. Kosawada, D. Sato, T. Nakamura, T. Kitajima, M. Umezu,
    • Journal Title

      35th Annual International Conference of the IEEE EMBS

      Volume: 403 Pages: 6232-6235

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Non-invasive Stiffness Detection Method for Living Cell Nucleus by Using Piezoelectric Micro Sensor2012

    • Author(s)
      Ken-ichi Konno, Tadashi Kosawada, Yasushi Kaneyama, Hiroya Endo, Zhonggang Feng
    • Journal Title

      IFMBE Proceedings

      Volume: 39 Pages: 290-293

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel Three-dimensional Micro Vibration Stage and Its Ability to Influence in Cellular Senescence2012

    • Author(s)
      Ken-ichi Konno, Tadashi Kosawada, Toru Ichita, Zhonggang Feng, Yasukazu Hozumi, Kaoru Goto
    • Journal Title

      IFMBE Proceedings

      Volume: 39 Pages: 274-277

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ヒトiPS細胞から神経細胞への分化・成長過程に及ぼす動的力学刺激の影響2014

    • Author(s)
      早坂 紘旗,真坂 洋平,菊池 駿佑,小沢田 正,馮 忠剛
    • Organizer
      日本機械学会Dynamics and Design Conference 2014
    • Place of Presentation
      上智大学
    • Year and Date
      2014-08-26 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] PLA多孔質体および動的力学刺激を用いたマウスニューロンの3次元ネットワーク形成の試み2014

    • Author(s)
      伊東 彬,永田 哲平,金子 暢生,小沢田 正,長谷川 麗,宇山 浩
    • Organizer
      日本機械学会Dynamics and Design Conference 2014
    • Place of Presentation
      上智大学
    • Year and Date
      2014-08-26 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Novel Method to Explore the Mechanical Inhomogeneity of Human Osteoblast Nucleus and Its Relationship to Cell Cycle2014

    • Author(s)
      T Kosawada, R Harada, R Ajiki, H Endo, Z Feng
    • Organizer
      JSME/ASME 2014 International Conference on Materials and Processing
    • Place of Presentation
      Detroit, USA
    • Year and Date
      2014-06-09 – 2014-06-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] i PS細胞の基礎 と 研究上のニーズ2014

    • Author(s)
      小沢田 正
    • Organizer
      i PS関連機器開発 参入促進オープンセミナー
    • Place of Presentation
      TKPガーデンシティ仙台
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] マウス神経細胞の3次元ネットワーク形成に及ぼす動的力学刺激の影響2013

    • Author(s)
      永田 哲平,小沢田 正,長谷川 麗,宇山 浩
    • Organizer
      日本機械学会東北支部第49期秋季講演会
    • Place of Presentation
      岩手大学
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒト骨芽細胞核の力学特性と細胞周期との関連に関する研究2013

    • Author(s)
      安食 亮介,遠藤 洋也,小沢田 正,馮 忠剛
    • Organizer
      日本機械学会Dynamics and Design Conference 2013
    • Place of Presentation
      九州産業大学
    • Related Report
      2013 Research-status Report
  • [Presentation] マウスi PS細胞の分化に及ぼす動的力学刺激の影響に関する研究2013

    • Author(s)
      小泉 智幸,宇賀神 一也,小沢田 正,馮 忠剛
    • Organizer
      日本機械学会Dynamics and Design Conference 2013
    • Place of Presentation
      九州産業大学
    • Related Report
      2013 Research-status Report
  • [Presentation] Non-invasive Stiffness Detection Method for Living Cell Nucleus by Using Piezoelectric Micro Sensor2012

    • Author(s)
      Ken-ichi Konno, Tadashi Kosawada, Yasushi Kaneyama, Hiroya Endo, Zhonggang Feng
    • Organizer
      World Congress on Medical Physics and Biomedical Engineering
    • Place of Presentation
      Beijing・China
    • Related Report
      2012 Research-status Report
  • [Presentation] Novel Three-dimensional Micro Vibration Stage and Its Ability to Influence in Cellular Senescence2012

    • Author(s)
      Ken-ichi Konno, Tadashi Kosawada, Toru Ichita, Zhonggang Feng, Yasukazu Hozumi, Kaoru Goto
    • Organizer
      World Congress on Medical Physics and Biomedical Engineering
    • Place of Presentation
      Beijing・China
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト骨芽細胞核の形状および力学特性評価法の開発2012

    • Author(s)
      遠藤 洋也,金山 寧,今野 健一,馮 忠剛, 小沢田 正
    • Organizer
      日本機械学会Dynamics and Design Conference 2012
    • Place of Presentation
      慶応大(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] マウスiPS細胞の分化過程における力学刺激の影響評価2012

    • Author(s)
      小泉 智幸,会田 和広,今野 健一,馮 忠剛,小沢田 正
    • Organizer
      日本機械学会Dynamics and Design Conference 2012
    • Place of Presentation
      慶応大(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 超小型3次元振動ステージの細胞培養への応用

    • Author(s)
      後藤 敬成,今野 健一,小沢田 正,馮 忠剛,八月朔日 泰和,後藤 薫
    • Organizer
      日本機械学会東北支部第48期秋季講演会
    • Place of Presentation
      八戸高専(青森県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 細胞内小胞の形状解析及び物質輸送に及ぼすダイアフラムの影響

    • Author(s)
      小池智哉,齋藤悠介,小沢田正
    • Organizer
      日本機械学会東北支部第48期秋季講演会
    • Place of Presentation
      八戸高専(青森県)
    • Related Report
      2012 Research-status Report
  • [Remarks] 小沢田「バイオメカニクス」研究室ホームページ

    • URL

      http://kosawada_lab.yz.yamagata-u.ac.jp/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi