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Development of polymeric macroporous hydrogels for the immobilization of enzymes using an emulsion-gelation method

Research Project

Project/Area Number 24656465
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Properties in chemical engineering process/Transfer operation/Unit operation
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

TOKUYAMA Hideaki  東京農工大学, 工学(系)研究科(研究院), 准教授 (10363029)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords反応・分離工学 / 化学工学 / 高分子合成 / 固定化酵素 / ゲル / エマルション
Research Abstract

Novel polymeric macroporous hydrogels were developed to entrap and immobilize enzymes for improved enzyme reaction process. The emulsion-gelation method using emulsions was used to simultaneously synthesize the gels and entrap enzymes in the randomly distributed, non-interconnected, sphere-like macropores. The lipase, immobilized within the macroporous hydrogel and organogel, successfully catalyzed the hydrolysis in aqueous media and the transesterification in organic media, respectively.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) (of which Invited: 1 results) Remarks (3 results)

  • [Journal Article] Preparation of polymeric macroporous hydrogels for the immobilization of enzymes using an emulsion-gelation method2014

    • Author(s)
      Ryuichi Sato, Takuro Kawakami, Hideaki Tokuyama
    • Journal Title

      Reactive & Functional Polymers

      Volume: 76 Pages: 8-12

    • DOI

      10.1016/j.reactfunctpolym.2014.01.001

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] エマルションゲル化法を用いた酵素固定化多孔質ゲルの作製と反応特性2014

    • Author(s)
      佐藤龍一, 徳山英昭
    • Organizer
      第63回高分子学会年次大会
    • Place of Presentation
      名古屋国際会議場(1Pa103)
    • Year and Date
      2014-05-28
    • Related Report
      2013 Final Research Report
  • [Presentation] エマルションゲル化法を用いた酵素固定化多孔質ゲルの作製と反応特性2014

    • Author(s)
      佐藤龍一, 徳山英昭
    • Organizer
      第63回高分子学会年次大会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] エマルションゲルおよび多孔質ゲルの開発2013

    • Author(s)
      徳山英昭
    • Organizer
      第23回日本MRS年次大会
    • Place of Presentation
      万国橋会議センター,横浜(M-I10-005)
    • Year and Date
      2013-12-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Application of porous hydrogels for immobilized enzyme reaction2013

    • Author(s)
      Ryuichi Sato, Hideaki Tokuyama
    • Organizer
      International Soft Matter Conference 2013
    • Place of Presentation
      Rome, Italy(POL-1762)
    • Year and Date
      2013-09-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Application of porous hydrogels for immobilized enzyme reaction2013

    • Author(s)
      Ryuichi Sato, Hideki Tokuyama
    • Organizer
      International Soft Matter Conference 2013
    • Place of Presentation
      Sapienza University of Rome, Rome, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] エマルションゲルおよび多孔質ゲルの開発2013

    • Author(s)
      徳山英昭
    • Organizer
      第23回日本MRS年次大会
    • Place of Presentation
      万国橋会議センター, 横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] エマルションゲル化法を用いた新規な固定化酵素多孔質ゲルの開発2012

    • Author(s)
      河上卓朗, 徳山英昭
    • Organizer
      化学工学会第44回秋季大会
    • Place of Presentation
      東北大学(XA2P43)
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] エマルションゲル化法を用いた新規な固定化酵素多孔質ゲルの開発

    • Author(s)
      河上卓朗
    • Organizer
      化学工学会第44回秋季大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.tuat.ac.jp/~tokuyama/

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京農工大学大学院工学府応用化学専攻徳山研究室ホームページ

    • URL

      http://www.tuat.ac.jp/~tokuyama/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京農工大学大学院工学府応用化学専攻徳山研究室ホームページ

    • URL

      http://www.tuat.ac.jp/~tokuyama/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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