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Circadian rhythmic control of differentiation of human stem cells

Research Project

Project/Area Number 24656495
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Biofunction/Bioprocess
Research InstitutionHokkaido University

Principal Investigator

TAKAGI Mutsumi  北海道大学, 工学(系)研究科(研究院), 教授 (20263212)

Co-Investigator(Renkei-kenkyūsha) FUJIWARA Masashi  北海道大学, 大学院工学研究院, 助教 (30229075)
HONMA Ken-ichi  北海道大学, 大学院医学研究科, 特任教授 (40113625)
NISHIDE Shinya  北海道大学, 大学院医学研究科, 助教 (40451398)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords細胞培養 / 時計遺伝子 / 間葉系幹細胞 / 分化 / トランスジェニックラット / グルコース / デキサメタゾン / 血清
Research Abstract

The effects of various cultivation operation on re-oscillation of circadian gene expression , especially on amplitude and phase of oscillation, were quantitatively clarified. The phase at the beginning of re-oscillation depended on the kind of cultivation operation including medium change, additions of glucose, large amount of serum, and dexamethasone, which knowledge might contribute on not only the study about the mechanism of re-oscillation but also the control methodology of the oscillation of circadian gene expression.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2013 Other

All Presentation (2 results)

  • [Presentation] ラットMSC様細胞における時計遺伝子振動に与える培地交換の影響2013

    • Author(s)
      山道愛菜、○切明研人、藤原政司、本間さと、本間研一、西出真也、高木睦
    • Organizer
      日本生物工学会年会広島大会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2013-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットMSC様細胞における時計遺伝子振動に与える培地交換の影響

    • Author(s)
      切明研人
    • Organizer
      日本生物工学会年会広島大会
    • Place of Presentation
      広島国際会議場(広島市)
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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