nanomanipulationof antibody based on liquid-binding peptide
Project/Area Number |
24656496
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Biofunction/Bioprocess
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Research Institution | Tohoku University |
Principal Investigator |
UMETSU Mitsuo 東北大学, 工学(系)研究科(研究院), 准教授 (70333846)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | ナノバイオ / 分子認識 / 蛋白質 |
Research Abstract |
Recently, we identified the peptide with affinity for liquid surface. In this study, we tried to use the peptide for manipulating proteins on liquid surface and clustering peptide in water solution. Consequently, the fusion of the liquid-binding peptide to GFP resulting in the formation of GFP membrane on the water-ionic liquid interface and the fusion of the peptide to antibody fragment led to the clustering of antibody fragment with avidity effect.
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Report
(3 results)
Research Products
(33 results)
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[Journal Article] Rapid and Sensitive Detection of Brain-Derived Neurotrophic Factor with a Plasmonic Chip2013
Author(s)
Keiko Tawa, Mari Satoh, Koichi Uegaki, Tomoko Hara, Masami Kojima, Hiroyuki Aota, Yoshiki Yokota, Takahiko Nakaoki, Mitsuo Umetsu, Hikaru Nakazawa, Izumi Kumagai
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Journal Title
Japanese Journal of Applied Physics
Volume: 52
Issue: 6S
Pages: 06GK01-06GK01
DOI
NAID
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Peer Reviewed
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[Journal Article] Quantum Dot Motion on Microtubules2012
Author(s)
Aurélien Sikora, Daniel Oliveira, Kyongwan Kim, Andrew L. Liao, Mitsuo Umetsu, Izumi Kumagai, Tadafumi Adschiri, Wonmuk Hwang, and Winfried Teizer
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Journal Title
Chemistry Letters
Volume: 41
Issue: 10
Pages: 1215-1217
DOI
NAID
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Peer Reviewed
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[Book] 進化分子工学2013
Author(s)
梅津 光央、中澤 光、服部 峰充
Total Pages
424
Publisher
エヌ・ティー・エス
Related Report