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Basic and applied study on AIDS-therapy using hybrid liposomes

Research Project

Project/Area Number 24656509
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Biofunction/Bioprocess
Research InstitutionSojo University

Principal Investigator

UEOKA Ryuichi  崇城大学, 生物生命学部, 客員研究員 (70099076)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsリポソーム / エイズ / エイズ関連腫瘍 / 細胞膜流動性 / 細胞膜 / ナノメディシン / 脂質
Research Abstract

We have produced hybrid liposomes (HL) which can be prepared by sonication of vesicular and micellar molecules in a buffer solution. We have investigated the anti-AIDS effects of HL and following results are obtained. (1)Remarkably high therapeutic effects were obtained in the mouse models of adult T-cell leukemia/lymphoma (ATLL) after the treatment with HL on the basis of relative organ weight and histological analysis using hematoxylin-eosin (HE) and immunohistochemical staining of CD4 and CD25. Prolonged survival was obtained in the mouse models of ATLL after the treatment with HL. (2)The anti-HIV-1 activity of cepharanthine (CEP), a natural product derived from Stephania cepharantha Hayata, was evaluated. CEP stabilized plasma membrane fluidity and inhibited HIV-1 envelope-dependent cell-to-cell fusion of HIV-1-infected cells as well as cell-free infection. These findings suggest that HL and CEP should be a new type of nanomedicinal anti-AIDS drug that targets cell-membranes.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (60 results)

All 2014 2013 2012 Other

All Journal Article (25 results) (of which Peer Reviewed: 24 results,  Open Access: 3 results) Presentation (30 results) (of which Invited: 2 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Cell cycle arrest by hybrid liposomes for human lung carcinoma cells2014

    • Author(s)
      Y. Komizu, M. Yukihara, Y. Matsumoto, R. Ueoka
    • Journal Title

      J. Carcinog. Mutagen

      Volume: 5 Issue: 01

    • DOI

      10.4172/2157-2518.1000157

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapeutic Effects of Cationic Hybrid Liposomes on the Hepatic Metastasis of Colon Carcinoma Along with Apoptosis <i>in Vivo</i>2014

    • Author(s)
      H. Ichihara, M. Hino, R. Ueoka, Y. Matsumoto
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 37 Issue: 3 Pages: 498-503

    • DOI

      10.1248/bpb.b13-00764

    • NAID

      130003390947

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cepharanthine inhibited HIV-1 cell-cell transmission and cell-free infection via modification of cell membrane fluidity2014

    • Author(s)
      K. Matsuda, S. Hattori, Y. Komizu, R. Kariya, R. Ueoka, S. Okada
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Issue: 9 Pages: 2115-2117

    • DOI

      10.1016/j.bmcl.2014.03.041

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapeutic effects of hybrid liposomes without drugs for rheumatoid arthritis2014

    • Author(s)
      Yoko Matsumoto, Hideaki Ichihara, Motoki Hino, Masayo Umebayashi, Ryuichi Ueoka
    • Journal Title

      Drug Delivery

      Volume: 21 Issue: 5 Pages: 619-626

    • DOI

      10.3109/10717544.2013.869635

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ハイブリッドリポソームによるがん治療と分子メカニズム2014

    • Author(s)
      上岡龍一, 市原英明, 古水雄志
    • Journal Title

      生物物理

      Volume: 54 Pages: 5-10

    • NAID

      130003391392

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Hybrid liposomes inhibit tumor growth and lung metastasis of murine osteosarcoma cells2013

    • Author(s)
      H. Kitajima, Y. Komizu, H. Ichihara, K. Goto, R. Ueoka
    • Journal Title

      Cancer Med

      Volume: (in press) Issue: 3 Pages: 267-278

    • DOI

      10.1002/cam4.67

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic Effects of Autologous Lymphocytes Activated with Trastuzumab for Xenograft Mouse Models of Human Breast Cancer2013

    • Author(s)
      S. Nakagawa, Y. Matsuoka, H. Ichihara, H. Yoshida, K. Yoshida, R. Ueoka
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 36 Issue: 5 Pages: 861-865

    • DOI

      10.1248/bpb.b12-01084

    • NAID

      130003361416

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] membranes of normal murine thymocytes and leukemic GRSL cells2013

    • Author(s)
      Yoshimichi Andoha, Susumu Okazakia, Ryuichi Ueoka
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Biomembranes

      Volume: 1828 Issue: 4 Pages: 1259-1270

    • DOI

      10.1016/j.bbamem.2013.01.005

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel Liposomes Composed of Dimyristoylphosphatidylcholine and Trehalose Surfactants Inhibit the Growth of Tumor Cells along with Apoptosis2013

    • Author(s)
      Y. Matsumoto, E. Cao, R. Ueoka
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 36 Issue: 8 Pages: 1258-1262

    • DOI

      10.1248/bpb.b13-00266

    • NAID

      130003361509

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunostimulatory Effects of Extract from <i>Nori</i> (<i>Porphyra yezoensis</i>) <i>in Vitro</i> and <i>in Vivo</i>2013

    • Author(s)
      北島 英樹, 古水 雄志, 市原 英明, 後藤 浩一, 土井 孝史, 稲野 達郎, 上岡 龍一
    • Journal Title

      KAGAKU KOGAKU RONBUNSHU

      Volume: 39 Issue: 4 Pages: 359-362

    • DOI

      10.1252/kakoronbunshu.39.359

    • NAID

      10031188074

    • ISSN
      0386-216X, 1349-9203
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth inhibition by novel liposomes including trehalose surfactant against hepatocarcinoma cells along with apoptosis2013

    • Author(s)
      Yoko Matsumoto, E. Cao, Ryuichi Ueoka
    • Journal Title

      Anticancer Research

      Volume: 33 Pages: 4727-4740

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic Effects of autologous lymphocytes activated with Trastuzumab for xenograft mouse models of human breast cancer2013

    • Author(s)
      Sinichirou Nakagawa
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume: 36

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effects of hybrid liposomes for mouse models of adult T-cell leukemia/lymphoma in vivo2012

    • Author(s)
      Y. Komizu, M. Yukihara, T. Ueoka, H. Ichihara, Y. Matsumoto, S. Okada, R. Ueoka
    • Journal Title

      Nano Bull.

      Volume: 1

    • URL

      http://www.gosciences.com/journals/index.php/nano/article/view/nano120105

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intravenous injection of hybrid liposomes suppresses the liver metastases in xenograft mouse models of colorectal cancer in vivo2012

    • Author(s)
      H. Ichihara, M. Hino, M. Umebayashi, Y. Matsumoto, R. Ueoka
    • Journal Title

      Eur. J. Med. Chem

      Volume: 57 Pages: 143-148

    • DOI

      10.1016/j.ejmech.2012.08.040

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-tumor Effects of Cationic Hybrid Liposomes against Colon Carcinoma along with Apoptosis <i>in Vitro</i>2012

    • Author(s)
      M. Hino, H. Ichihara, Y. Matsumoto, R. Ueoka
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 35 Issue: 11 Pages: 2097-2101

    • DOI

      10.1248/bpb.b12-00633

    • NAID

      130001872276

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Selective accumulation and growth inhibition of hybrid liposomes to human hepatocellular carcinoma cells in relation to fluidity of plasma membranes2012

    • Author(s)
      Y. Komizu, H. Ueoka, R. Ueoka, Biochem
    • Journal Title

      Biophys. Res. Commun

      Volume: 418 Issue: 1 Pages: 81-86

    • DOI

      10.1016/j.bbrc.2011.12.134

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hybrid liposomes affect cellular lipid constituents and caveolae structures2012

    • Author(s)
      Cao K
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 22 Issue: 4 Pages: 1731-1733

    • DOI

      10.1016/j.bmcl.2011.12.093

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hybrid liposomes inhibit growth and invasion of human osteosarcoma cells leading to apoptosis2012

    • Author(s)
      Hideki Kitajima
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 22 Issue: 4 Pages: 1784-1787

    • DOI

      10.1016/j.bmcl.2011.12.031

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antimelanogenic and antioxidative effects of residual powders from Shochu distillation remnants2012

    • Author(s)
      Masahiro Ohgidani
    • Journal Title

      Food Chemistry

      Volume: 132 Issue: 4 Pages: 2140-2143

    • DOI

      10.1016/j.foodchem.2011.12.049

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phase behavior of a lipid bilayer system studied by a replica-exchange molecular dynamics simulation2012

    • Author(s)
      T.Nagai, R.Ueoka, Y.Okamoto
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 81 Issue: 2 Pages: 24002-24010

    • DOI

      10.1143/jpsj.81.024002

    • NAID

      40019151203

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anticancer Effects of Residual Powder from Barley-<i>Shochu</i> Distillation Remnants against the Orthotopic Xenograft Mouse Models of Hepatocellular Carcinoma <i>in Vivo</i>2012

    • Author(s)
      Masahiro Ohgidani
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 35 Issue: 6 Pages: 984-987

    • DOI

      10.1248/bpb.35.984

    • NAID

      130001872186

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Residual powders from Shochu distillation remnants induce apoptosis in human hepatoma cells via the caspase-independent pathway2012

    • Author(s)
      Masahiro Ohgidani
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 114 Issue: 1 Pages: 104-109

    • DOI

      10.1016/j.jbiosc.2012.02.026

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] New Cancer Immunotherapy Using Autologous Lymphocytes Activated with Trastuzumab2012

    • Author(s)
      Sinichirou Nakagawa
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 35 Issue: 8 Pages: 1213-1215

    • DOI

      10.1248/bpb.b12-00378

    • NAID

      130001872153

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effects of hybrid liposomes for mouse models of adult T-cell leukemia/lymphoma in vivo2012

    • Author(s)
      Yuji Komizu
    • Journal Title

      Nano Bulletin

      Volume: 1

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 人工膜および細胞膜の揺らぎとがん治療2012

    • Author(s)
      上岡龍一
    • Journal Title

      LSアドバンス

      Volume: 11 Pages: 23-29

    • NAID

      10029601562

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] HAMLET/BAMLETの原発性滲出性悪性リンパ腫に対する抗腫瘍効果2013

    • Author(s)
      刈谷龍昇,松田幸樹,中村敬,古水雄志,鈴木元,桑島邦博,上岡龍一,岡田誠治
    • Organizer
      第27回日本エイズ学会学術集会
    • Place of Presentation
      熊本県
    • Year and Date
      2013-11-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 三環系クマリンGUT-70によるHIV-1侵入抑制効果2013

    • Author(s)
      松田幸樹,服部真一朗,刈谷龍昇,古水雄志,工藤恵理子,木村晋也,上岡龍一,岡田誠治
    • Organizer
      第23回日本サイトメトリー学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2013-06-22
    • Related Report
      2013 Final Research Report
  • [Presentation] ハイブリッドリポソームの肺がん細胞に対する細胞周期停止およびアポトーシス誘導によるがん抑制機構2013

    • Author(s)
      古水雄志, 松本陽子, 上岡龍一
    • Organizer
      第18回日本がん分子標的治療学会学術集会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 三環系クマリン GUT-70 による HIV-1 侵入抑制効果2013

    • Author(s)
      松田幸樹、服部真一朗、刈谷龍昇、古水雄志、工藤恵理子、木村晋也、上岡龍一、岡田誠治
    • Organizer
      第 23 回日本サイトメトリー学会学術集会
    • Place of Presentation
      日本医科大学橘桜会館(東京都文京区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cell cycle arrest by adding hybrid liposomes for lung tumor2013

    • Author(s)
      Yoko Matsumoto, Yuji Komizu, Mamiko Yukihara, Ryuichi Ueoka
    • Organizer
      The 72nd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Therapeutic effects of hybrid liposomes for mouse models of adult T-cell leukemia/lymphoma in vitro and in vivo2013

    • Author(s)
      Yuji Komizu, Hideaki Ichihara, Yoko Matsumoto, Ryuichi Ueoka
    • Organizer
      The 72nd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Chemotherapy with hybrid liposomes for acute lymphatic leukemia leading to apoptosis in vivo2013

    • Author(s)
      Hideaki Ichihara, Yoko Matsumoto, Ryuichi Ueoka
    • Organizer
      The 72nd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Immunostimulation effects of extract from nori (Porphyra yezoensis) in vitro and in vivo2013

    • Author(s)
      Koichi Goto, Hideki Kitajima, Yuji Komizu, Hideaki Ichihara, Takashi Doi, Tatsuro Inano, Ryuichi Ueoka
    • Organizer
      The 72nd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Targeting ceramide homeostasis and metastasis-prone phenotypes in human lung cancer cells2013

    • Author(s)
      Motoshi Suzuki, Shoichi Kato, Yuji Komizu, Ryuichi Ueoka, Chinatsu Arima, Kiyoshi Yanagisawa, Keiko Koizumi, Takashi Murate, Mamoru Kyogashima, Takashi Takahashi
    • Organizer
      The 72nd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] HAMLET/BAMLET の原発性滲出性悪性リンパ腫に対する抗腫瘍効果2013

    • Author(s)
      刈谷龍昇、松田幸樹、中村敬、古水雄志、鈴木元、桑島邦博、上岡龍一、岡田誠治
    • Organizer
      第27回日本エイズ学会学術集会
    • Place of Presentation
      市民会館崇城大学ホール(熊本市中央区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 三環系クマリン GUT-70 による HIV-1 侵入抑制効果2013

    • Author(s)
      松田 幸樹、服部 真一朗、刈谷 龍昇、古水雄志、工藤恵理子、後藤裕樹、田浦学、木村晋也、上岡龍一、岡田誠治
    • Organizer
      第27回日本エイズ学会学術集会
    • Place of Presentation
      市民会館崇城大学ホール(熊本市中央区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Membrane-targeted nanotherapy with hybrid liposomes for cancer cells leading to apoptosis2012

    • Author(s)
      R Ueoka
    • Organizer
      The 6th International Symposium of"Molecular Science of Fluctuation Toward Biological Functions"
    • Place of Presentation
      京都府
    • Year and Date
      2012-12-06
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Anti-invasive effect of hybrid liposomes on osteosarcoma cells2012

    • Author(s)
      北島英樹,古水雄志,市原英明,上岡龍一
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞膜及び人工膜の揺らぎが関与する制がん機能メカニズム2012

    • Author(s)
      上岡龍一
    • Organizer
      新学術領域研究「揺らぎが機能を決める生命分子の科学」平成24年度合同班会議
    • Place of Presentation
      宮城県
    • Year and Date
      2012-08-01
    • Related Report
      2013 Final Research Report
  • [Presentation] ハイブリッドリポソームの肺がん細胞に対する細胞周期制御2012

    • Author(s)
      行原 真美子
    • Organizer
      第16回日本がん分子標的治療学会学術集会
    • Place of Presentation
      西日本総合展示場(福岡県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 細胞膜及び人工膜の揺らぎが関与する制がん機能メカニズム2012

    • Author(s)
      上岡 龍一
    • Organizer
      新学術領域研究「揺らぎが機能を決める生命分子の科学」平成 24年度合同班会議
    • Place of Presentation
      作並温泉 ゆづくしSalon一の坊(宮城県)
    • Related Report
      2012 Research-status Report
  • [Presentation] アポトーシス誘導による疾患治療と細胞膜の揺らぎ2012

    • Author(s)
      松本 陽子
    • Organizer
      新学術領域研究「揺らぎが機能を決める生命分子の科学」平成 24年度合同班会議
    • Place of Presentation
      作並温泉 ゆづくしSalon一の坊(宮城県)
    • Related Report
      2012 Research-status Report
  • [Presentation] がん細胞膜の揺らぎをターゲットとするハイブリッドリポソームのがん抑制メカニズム2012

    • Author(s)
      上岡 龍一
    • Organizer
      新学術領域「揺らぎと生体機能」「水和とATP」合同公開シンポ ジウム 「ゆらぎと水-生命のエネルギーと機能の分子機構を探 る」
    • Place of Presentation
      大阪ガーデンパレス(大阪府)
    • Related Report
      2012 Research-status Report
  • [Presentation] アポトーシス誘導による疾患治療と細胞膜の揺らぎ2012

    • Author(s)
      松本 陽子
    • Organizer
      新学術領域「揺らぎと生体機能」「水和とATP」合同公開シンポ ジウム 「ゆらぎと水-生命のエネルギーと機能の分子機構を探 る」
    • Place of Presentation
      大阪ガーデンパレス(大阪府)
    • Related Report
      2012 Research-status Report
  • [Presentation] テロメア DNA 四重らせん構造の揺らぎと機能に関する分子科学的研究2012

    • Author(s)
      松下  琢
    • Organizer
      新学術領域「揺らぎと生体機能」「水和とATP」合同公開シンポ ジウム 「ゆらぎと水-生命のエネルギーと機能の分子機構を探 る」
    • Place of Presentation
      大阪ガーデンパレス(大阪府)
    • Related Report
      2012 Research-status Report
  • [Presentation] Anti-invasive effect of hybrid liposomes on osteosarcoma cells2012

    • Author(s)
      北島 英樹
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] Anti-tumor effects of cationic Hybrid Liposomes against Colon Carcinoma along with Apoptosis in vitro2012

    • Author(s)
      日野 元貴
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] Membrane-targeted nanotherapy with hybrid liposomes for cancer cells leading to apoptosis2012

    • Author(s)
      上岡 龍一
    • Organizer
      The 6th International Symposium of “Molecular Science of Fluctuation Toward Biological Functions”
    • Place of Presentation
      京都テルサ(京都府)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Effect of Cations on G-quadruplex Structure and Fluctuation of Telomeric DNA2012

    • Author(s)
      松下  琢
    • Organizer
      The 6th International Symposium of “Molecular Science of Fluctuation Toward Biological Functions”
    • Place of Presentation
      京都テルサ(京都府)
    • Related Report
      2012 Research-status Report
  • [Presentation] Inhibitory effects of hybrid liposomes on the growth of synoviocyte causing rheumatoid arthritis in vivo2012

    • Author(s)
      市原 英明
    • Organizer
      The 6th International Symposium of “Molecular Science of Fluctuation Toward Biological Functions”
    • Place of Presentation
      京都テルサ(京都府)
    • Related Report
      2012 Research-status Report
  • [Presentation] Cell-cycle regulation by hybrid liposomes for lung tumor cells2012

    • Author(s)
      古水 雄志
    • Organizer
      The 6th International Symposium of “Molecular Science of Fluctuation Toward Biological Functions”
    • Place of Presentation
      京都テルサ(京都府)
    • Related Report
      2012 Research-status Report
  • [Presentation] Hybrid liposomes inhibits tumor growth and lung metastasis of murine osteosarcoma cells2012

    • Author(s)
      北島 英樹
    • Organizer
      The 6th International Symposium of “Molecular Science of Fluctuation Toward Biological Functions”
    • Place of Presentation
      京都テルサ(京都府)
    • Related Report
      2012 Research-status Report
  • [Presentation] Anti-tumor effects of Cationic hybrid liposomes Against colon carcinoma along with apoptosis2012

    • Author(s)
      日野 元貴
    • Organizer
      The 6th International Symposium of “Molecular Science of Fluctuation Toward Biological Functions”
    • Place of Presentation
      京都テルサ(京都府)
    • Related Report
      2012 Research-status Report
  • [Presentation] New type of hybrid liposomes composed of dimyristoylphosphatidyl- choline and trehalose surfactant for the inhibition of tumor growth2012

    • Author(s)
      曹 娥
    • Organizer
      The 6th International Symposium of “Molecular Science of Fluctuation Toward Biological Functions”
    • Place of Presentation
      京都テルサ(京都府)
    • Related Report
      2012 Research-status Report
  • [Presentation] Trastuzumabで刺激した強化免疫細胞治療の可能性2012

    • Author(s)
      松岡 裕介
    • Organizer
      The 6th International Symposium of “Molecular Science of Fluctuation Toward Biological Functions”
    • Place of Presentation
      倉敷市芸文館(岡山県)
    • Related Report
      2012 Research-status Report
  • [Book] ハイブリッドリポソームの基礎と応用」揺らぎ・ダイナミクスと生体機能, Dojin Bioscience2013

    • Author(s)
      上岡龍一
    • Total Pages
      368
    • Publisher
      (株)化学同人
    • Related Report
      2013 Final Research Report
  • [Book] 生体分子の動きを探る -揺らぎと生体機能-(仮題)Dojin Bioscience2013

    • Author(s)
      上岡龍一
    • Publisher
      化学同人
    • Related Report
      2012 Research-status Report
  • [Remarks] 崇城大学生物生命学部応用生命科学科医用生体工学講座

    • URL

      http://www.life.sojo-u.ac.jp/biomed/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 崇城大学生物生命学部応用生命科学科医用生体工学講座

    • URL

      http://www.life.sojo-u.ac.jp/biomed/index.html

    • Related Report
      2012 Research-status Report
  • [Remarks] 文部科学省科学研究費補助金 新学術領域研究「揺らぎが機能を決める生命分子の科学」

    • URL

      http://kuchem.kyoto-u.ac.jp/hikari/yuragi/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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