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X-ray computed tomography for finding tumor without using contrast agent

Research Project

Project/Area Number 24656570
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Nuclear engineering
Research InstitutionKyoto University

Principal Investigator

KANNO Ikuo  京都大学, 工学(系)研究科(研究院), 教授 (50234167)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
KeywordsX線コンピュータ断層撮影 / エネルギー分解 / 実効原子番号 / 線減弱係数 / X線 / コンピュータ断層撮影 / エネルギー分解CT / フィルタX線 / 物質識別 / 低被曝
Research Abstract

To find cancers by X-ray computed tomography (CT), iodine contrast agent is injected into blood vessel. The iodine contrast agent, however, has side effect, such as a fatality among ten thousand patients. It is desirable to find cancers without using iodine contrast agent. To meet this demand, we performed effective atomic number measurements with energy-resolved CT. Normally, the measurement of effective atomic number is conducted with using two monochromatic X-rays. We employed white X-rays with defining two narrow energy ranges as quasi-monochromatic X-rays in the analysis. Employed phantom was a cylindrical acrylic 3 cm in diameter with 2 diameter aluminum rod in the center. We measured linear attenuation coefficients for X-rays in two narrow energy ranges and estimated the ratio of them. The obtained effective atomic numbers showed excellent agreement with the theoretical ones within 1% of errors.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (46 results)

All 2014 2013 2012 Other

All Journal Article (11 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 3 results) Presentation (29 results) (of which Invited: 1 results) Remarks (3 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Using Energy-resolved X-ray Computed Tomography with a Current Mode Detector to Distinguish Materials2014

    • Author(s)
      I. Kanno, R. Imamura, Y. Yamashita, M. Ohtaka, M. Hashimoto, K. Ara and H. Onabe
    • Journal Title

      Jpn.J.Appl.Phys.

      Volume: 53 Pages: 56601-56601

    • NAID

      210000143759

    • Related Report
      2013 Final Research Report
  • [Journal Article] Low-dose Exposure Energy-Resolved X-ray Computed Tomography using a Contrast Agent with a High-energy K-edge2014

    • Author(s)
      Y. Yamashita, K. Shima, I. Kanno, M. Ohtaka, M. Hashimoto, K. Ara, H. Onabe
    • Journal Title

      J.Nucl.Sci.Technol.

      Volume: 51 Pages: 91-97

    • Related Report
      2013 Final Research Report
  • [Journal Article] Low-dose Exposure Energy-Resolved X-ray Computed Tomography using a Contrast Agent with a High-energy K-edge2014

    • Author(s)
      Y.Yamashita, I. Kanno, 他.
    • Journal Title

      Journal of Nuclear Science and Technology

      Volume: 51 Issue: 1 Pages: 91-97

    • DOI

      10.1080/00223131.2013.849621

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Using Energy-resolved X-ray Computed Tomography with a Current Mode Detector to Distinguish Materials2014

    • Author(s)
      I. Kanno, R. Imamura, Y. Yamashita, M. Ohtaka, M. Hashimoto, K. Ara and H. Onabe
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 53 Issue: 5 Pages: 56601-4

    • DOI

      10.7567/jjap.53.056601

    • NAID

      210000143759

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computed Tomography Reconstruction from Two Transmission Measurements for Iodine-marked Cancer Detection2013

    • Author(s)
      I. Kanno, K. Shima, H. Shimazaki, Y. Yamashita, K. Watanabe, M. Ohtaka, M. Hashimoto, K. Ara and H. Onabe
    • Journal Title

      J.Nucl.Sci.Technol.

      Volume: 50 Pages: 1020-1033

    • Related Report
      2013 Final Research Report
  • [Journal Article] Energy-resolved Computed Tomography Measurements of Iron Solution and Adipose as a Simulation for Estimating the Iron Concentration in the Human Liver2013

    • Author(s)
      Y. Yamashita, H. Shimazaki, K. Shima, I. Kanno, M. Ohtaka, M. Hashimoto, K. Ara and H. Onabe
    • Journal Title

      J.Nucl.Sci.Technol.

      Volume: 50 Pages: 376-380

    • Related Report
      2013 Final Research Report
  • [Journal Article] Energy- resolved Computed Tomography Measurements of Iron Solution and Adipose as a Simulation for Estimating the Iron Concentration in the Human Liver2013

    • Author(s)
      Y.Yamashita, I. Kanno, 他.
    • Journal Title

      Journal of Nuclear Science and Technology

      Volume: 50 Issue: 4 Pages: 376-380

    • DOI

      10.1080/00223131.2013.773163

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Computed Tomography Reconstruction from Two Transmission Measurements for Iodine-marked Cancer Detection2013

    • Author(s)
      I.Kanno, K.Shima, 他.
    • Journal Title

      Journal of Nuclear Science and Technology

      Volume: 50 Issue: 10 Pages: 1020-1033

    • DOI

      10.1080/00223131.2013.830077

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A transXend detector- principle and Applications2012

    • Author(s)
      I. Kanno
    • Journal Title

      Prog.in Nucl.Sci.and Technol.

      Volume: 3 Pages: 1-1

    • Related Report
      2013 Final Research Report
  • [Journal Article] Low Dose Exposure Diagnosis with a transXend Detector Aiming for Iodine-marked Cancer Detection2012

    • Author(s)
      I. Kanno, H. Shimazaki, R. Imamura, Y. Yamashita, K. Shima, M. Ohtaka, M. Hashimoto, K. Ara and H. Onabe
    • Journal Title

      J.Nucl.Sci.and Technol.

      Volume: 49 Pages: 937-946

    • NAID

      120005323011

    • Related Report
      2013 Final Research Report
  • [Journal Article] Third-generation Computed Tomography with Energy Information of X-rays using a CdTe Flat Panel Detector2012

    • Author(s)
      I. Kanno, R. Imamura, Y. Minami, M. Ohtaka, M. Hashimoto, K. Ara, H. Onabe
    • Journal Title

      Nucl.Instrum.Meth.in Phys.Res.

      Volume: A695 Pages: 268-271

    • Related Report
      2013 Final Research Report
  • [Presentation] エネルギー分解X線コンピュータ断層撮影による実効原子番号の測定2014

    • Author(s)
      木村優志, 山下良樹, 井上福太郎, 神野郁夫, 大高雅彦, 橋本周, 荒邦章, 尾鍋秀明
    • Organizer
      応用物理学会
    • Place of Presentation
      青山学院大学(20a-F1-1)
    • Year and Date
      2014-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] フラットパネル検出器を用いたエネルギー分解コンピュータ断層撮影法の検証2014

    • Author(s)
      伊良皆拓, 桑原潤一, 山下良樹, 木村優志, 北原理, 小川剛史, 船引綾乃, 叶井絵梨, 神野郁夫, 伊藤秋男, 門前一, 平岡真寛
    • Organizer
      応用物理学会
    • Place of Presentation
      青山学院大学(20a-F1-2)
    • Year and Date
      2014-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 平板放射線検出器を用いたエネルギー分解X線コンピュータ断層撮影法の開発2014

    • Author(s)
      小川剛史, 山下良樹, 神野郁夫, 眞正浄光, 大高雅彦, 橋本周, 荒邦章, 尾鍋秀明
    • Organizer
      応用物理学会
    • Place of Presentation
      青山学院大学(19a-PA1-25)
    • Year and Date
      2014-03-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 計算応答関数による積層及び平面transXend検出器を用いたエネルギー分解CTの比較2014

    • Author(s)
      北原理, 山下良樹, 小川剛史, 木村優志, 神野郁夫, 大高雅彦, 橋本周, 荒邦章, 尾鍋秀明
    • Organizer
      応用物理学会
    • Place of Presentation
      青山学院大学(19a-PA1-26)
    • Year and Date
      2014-03-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 電流モード検出器transXendを用いたエネルギー分解コンピュータ断層撮影法2013

    • Author(s)
      神野郁夫
    • Organizer
      日本学術振興会「放射線科学とその応用第186委員会」
    • Place of Presentation
      放射線医学総合研究所
    • Year and Date
      2013-11-06
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Measurement of Atomic Numbers Using Energy-resolved Computed Tomography2013

    • Author(s)
      Y. Yamashita, M. Kimura, M. Kitahara, I. Kanno, M. Ohtaka, M. Hashimoto, K. Ara, H. Onabe
    • Organizer
      IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Place of Presentation
      大韓民国ソウル(M12-28)
    • Year and Date
      2013-10-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Computed Tomography of Acrylic Phantom with Iodine and Aluminum Resoctructed by Two Transmission Measurements2013

    • Author(s)
      I. Kanno, K. Shima, H. Shimazaki, Y. Yamashita, K. Watanabe, M. Ohtaka, M. Hashimoto, K. Ara, H. Onabe
    • Organizer
      IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Place of Presentation
      大韓民国ソウル(M12-18)
    • Year and Date
      2013-10-30
    • Related Report
      2013 Final Research Report
  • [Presentation] エネルギー分解CTによる実効原子番号測定2013

    • Author(s)
      山下良樹, 島一成, 木村優志, 神野郁夫, 大高雅彦, 橋本周, 荒邦章, 尾鍋秀明
    • Organizer
      応用物理学会
    • Place of Presentation
      同志社大学(16p-A12-6)
    • Year and Date
      2013-09-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 高エネルギーK吸収端造影剤とエネルギー分解による低被曝化CT法2013

    • Author(s)
      山下良樹, 島一成, 神野郁夫, 大高雅彦, 橋本周, 荒邦章, 尾鍋秀明
    • Organizer
      応用物理学会
    • Place of Presentation
      同志社大学(16p-A12-7)
    • Year and Date
      2013-09-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 多種シンチレータ平面transXend検出器を用いた物質厚さ推定の可能性2013

    • Author(s)
      北原理, 山下良樹, 小川剛史, 木村優志, 神野郁夫, 福田健太郎, 大高雅彦, 橋本周, 荒邦章, 尾鍋秀明
    • Organizer
      応用物理学会
    • Place of Presentation
      同志社大学(16p-A12-8)
    • Year and Date
      2013-09-16
    • Related Report
      2013 Final Research Report
  • [Presentation] X線エネルギー分布を用いた物質厚さ分布測定と断層画像の再構成2013

    • Author(s)
      神野郁夫, 島一成, 山下良樹, 大高雅彦, 橋本周, 荒邦章, 尾鍋秀明
    • Organizer
      日本原子力学会
    • Place of Presentation
      八戸工業大学(C33)
    • Year and Date
      2013-09-03
    • Related Report
      2013 Final Research Report
  • [Presentation] エネルギー分解CTによる実効原子番号測定2013

    • Author(s)
      山下良樹, 神野郁夫, 木村優志, 大高雅彦, 橋本周, 荒邦章, 尾鍋秀明
    • Organizer
      日本原子力学会
    • Place of Presentation
      八戸工業大学(C34)
    • Year and Date
      2013-09-03
    • Related Report
      2013 Final Research Report
  • [Presentation] transXend検出器(エネルギー分解CTのための電流モード検出器)の開発と低被曝CTへの応用2013

    • Author(s)
      神野郁夫
    • Organizer
      日本医学物理学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-04-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 超低被曝量診断を目指したtransXend検出器出力の多変量解析によるX線画像化2012

    • Author(s)
      神野郁夫, 島一成, 島崎紘亘, 山下良樹, 大高雅彦, 橋本周, 荒邦章, 尾鍋秀明
    • Organizer
      日本原子力学会
    • Place of Presentation
      広島大学(I43)
    • Year and Date
      2012-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation] エネルギー分解CTによるヨウ素とタングステンの識別2012

    • Author(s)
      山下良樹, 島一成, 北原理, 神野郁夫, 大高雅彦, 橋本周, 荒邦章, 尾鍋秀明
    • Organizer
      応用物理学会
    • Place of Presentation
      愛媛大学(13p-C7-7)
    • Year and Date
      2012-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] transXend検出器を用いた低被曝物質識別法2012

    • Author(s)
      島一成, 島崎紘亘, 山下良樹, 神野郁夫, 大高雅彦, 橋本周, 荒邦章, 尾鍋秀明
    • Organizer
      応用物理学会
    • Place of Presentation
      愛媛大学(13p-C7-8)
    • Year and Date
      2012-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 多種シンチレータ同一平面transXend検出器を用いたエネルギーCT測定2012

    • Author(s)
      北原理, 山下良樹, 島一成, 神野郁夫, 福田健太郎, 大高雅彦, 橋本周, 荒邦明, 尾鍋秀明
    • Organizer
      応用物理学会
    • Place of Presentation
      愛媛大学(13p-C7-9)
    • Year and Date
      2012-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Energy-resolved X-ray computed tomography for detecting tungsten as a substitute for gold contrast agent2012

    • Author(s)
      Y. Yamashita, I. Kanno, K. Shima, M. Ohtaka, M. Hashimoto, K. Ara, H. Onabe
    • Organizer
      International Symposium on Radiation Physics
    • Place of Presentation
      Rio de Janeiro, Brazil(A.09.C.28)
    • Related Report
      2013 Final Research Report
  • [Presentation] エネルギー分解CTによる ヨウ素とタングステンの識別2012

    • Author(s)
      山下良樹,島一成,北原理,神野郁夫,大高雅彦,橋本周,荒邦章,尾鍋秀明
    • Organizer
      応用物理学会
    • Place of Presentation
      松山大学
    • Related Report
      2012 Research-status Report
  • [Presentation] transXend検出器を用いた 低被曝での物質識別法2012

    • Author(s)
      島一成,島崎紘亘,山下良樹,神野郁夫,大高雅彦,橋本周,荒邦章,尾鍋秀明
    • Organizer
      応用物理学会
    • Place of Presentation
      松山大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 多種シンチレータ同一平面transXend検出器を用いたエネルギーCT測定2012

    • Author(s)
      北原理,山下良樹,島一成,神野郁夫,大高雅彦,橋本周,荒邦章,福田健太郎, 尾鍋秀明
    • Organizer
      応用物理学会
    • Place of Presentation
      松山大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 超低被曝量診断を目指した transXend検出器出力の 多変量解析によるX線画像化2012

    • Author(s)
      神野郁夫,島一成,島崎紘亘, 山下良樹 大高雅彦,橋本周,荒 邦章 尾鍋秀明
    • Organizer
      日本原子力学会
    • Place of Presentation
      広島大学
    • Related Report
      2012 Research-status Report
  • [Presentation] transXend検出器 (エネルギー分解CTのための電流モード検出器) の開発と 低被曝CTへの応用

    • Author(s)
      神野郁夫
    • Organizer
      日本医学物理学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] エネルギー分解CTによる実効原子番号測定

    • Author(s)
      山下 良樹,島 一成,木村 優志,神野 郁夫,大高 雅彦,橋本 周,荒 邦章,尾鍋 秀明
    • Organizer
      応用物理学会
    • Place of Presentation
      同志社大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多種シンチレータ平面transXend 検出器を用いた物質厚さ推定の可能性

    • Author(s)
      北原 理, 山下良樹, 小川剛史, 木村優志, 神野郁夫, 福田健太郎, 大高雅彦, 橋本 周, 荒 邦章, 尾鍋秀明
    • Organizer
      応用物理学会
    • Place of Presentation
      同志社大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] X線エネルギー分布を用いた物質厚さ分布測定と断層画像の再構成

    • Author(s)
      神野郁夫,島 一成,山下良樹,大高雅彦,橋本 周,荒 邦章,尾鍋秀明
    • Organizer
      日本原子力学会
    • Place of Presentation
      八戸工業大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] エネルギー分解CTによる実効原子番号測定

    • Author(s)
      山下良樹,神野郁夫,木村優志,大高雅彦,橋本 周,荒 邦章,尾鍋秀明
    • Organizer
      日本原子力学会
    • Place of Presentation
      八戸工業大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Computed Tomography of Acrylic Phantom with Iodine and Aluminum Resoctructed by Two Transmission Measurements

    • Author(s)
      I. Kanno, K. Shima, H. Shimazaki, Y. Yamashita, K. Watanabe, M. Ohtaka, M. Hashimoto, K. Ara, H. Onabe
    • Organizer
      IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Place of Presentation
      Seoul
    • Related Report
      2013 Annual Research Report
  • [Presentation] Measurement of Atomic Numbers Using Energy-resolved Computed Tomography

    • Author(s)
      Y. Yamashita, M. Kimura, M. Kitahara, I. Kanno, M. Ohtaka, M. Hashimoto, K. Ara, H. Onabe
    • Organizer
      IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Place of Presentation
      Seoul
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.nucleng.kyoto-u.ac.jp/People/Kanno/kanno.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 神野郁夫

    • URL

      http://www.nucleng.kyoto-u.ac.jp/People/Kanno/kanno.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 神野郁夫

    • URL

      http://www.nucleng.kyoto-u.ac.jp/People/Kanno/kanno.html

    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] X線CT装置および該方法2013

    • Inventor(s)
      神野郁夫
    • Industrial Property Rights Holder
      神野郁夫
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] X-ray CT Apparatus and Method Thereof2012

    • Inventor(s)
      神野郁夫
    • Industrial Property Rights Holder
      神野郁夫
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2012-05-15
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 放射線検出器

    • Inventor(s)
      神野郁夫
    • Industrial Property Rights Holder
      荒邦章
    • Industrial Property Rights Type
      特許
    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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