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Change of telomere length by stress

Research Project

Project/Area Number 24657008
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Genetics/Genome dynamics
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

ISHII Shunsuke  独立行政法人理化学研究所, 石井分子遺伝学研究室, 上席研究員 (00124785)

Project Period (FY) 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywordsテロメア / ストレス / ATF-7
Research Abstract

It was reported that various stresses including psychological stress shorten the telomere length. This suggests the possibility that psychological stress affects longevity. However, due to its unknown mechanism, this has not yet been generally accepted. We have shown that a stress-responsive transcription factor ATF-7, a member of ATF-2 family transcription factors, contributes to the stress-induced telomere shortening.

Report

(2 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (11 results)

All 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.2013

    • Author(s)
      Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
    • Journal Title

      Neuropsychopharmacology

      Volume: 38(8) Issue: 8 Pages: 1409-25

    • DOI

      10.1038/npp.2013.38

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Su(fu) switches Rdx functions to fine-tune hedgehog signaling in the Drosophila wing disk2013

    • Author(s)
      Seong KH & Ishii S
    • Journal Title

      Genes Cells

      Volume: 18 Issue: 1 Pages: 66-78

    • DOI

      10.1111/gtc.12018

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inheritance and memory of stress-induced epigenome change : roles played by the ATF-2 family of transcription factors2012

    • Author(s)
      Seong KH, Maekawa T & Ishii S
    • Journal Title

      Genes Cells

      Volume: 17 Issue: 4 Pages: 249-263

    • DOI

      10.1111/j.1365-2443.2012.01587.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation2012

    • Author(s)
      Kanei-Ishii C, Nomura T, Egoh A & Ishii S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 426 Issue: 1 Pages: 59-64

    • DOI

      10.1016/j.bbrc.2012.08.032

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] ストレスによるエピゲノム変化の遺伝2012

    • Author(s)
      石井俊輔
    • Organizer
      第85回日本生化学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Deficiency of Schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia2012

    • Author(s)
      宮川剛, 高雄啓三, 萩原英雄, 大平耕司, 昌子浩孝, 服部聡子, 小清水久嗣, 梅森十三, 高木豪, 石井俊輔
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] マクロファージの炎症時におけるATF-7の機能解析2012

    • Author(s)
      吉田圭介, 前川利男, Renard-Guillet Claire, 白髭克彦, 石井俊輔
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-13
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 転写因子ATF-7を介したストレスによるテロメアの長さの制御2012

    • Author(s)
      前川利男,劉彬彬, 吉田圭介, 仲村賢一, 田久保海誉, 石井俊輔
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-13
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] ショウジョウバエにおけるストレス依存的エピジェネティック制御とその遺伝の解析2012

    • Author(s)
      成耆鉉,李棟, 中邑亮一, 石井俊輔
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-12
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Role of ATF-2 family transcription factors in inheritance of epigenetic change induced by stress2012

    • Author(s)
      石井俊輔
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2012-05-31
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Remarks]

    • URL

      http://rtcweb.rtc.riken.jp/lab/mg/mg.html

    • Related Report
      2012 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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