Change of telomere length by stress

• Project/Area Number: 24657008
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Genetics/Genome dynamics
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: ISHII Shunsuke 独立行政法人理化学研究所, 石井分子遺伝学研究室, 上席研究員 (00124785)
• Project Period (FY): 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: テロメア / ストレス / ATF-7

Research Abstract

It was reported that various stresses including psychological stress shorten the telomere length. This suggests the possibility that psychological stress affects longevity. However, due to its unknown mechanism, this has not yet been generally accepted. We have shown that a stress-responsive transcription factor ATF-7, a member of ATF-2 family transcription factors, contributes to the stress-induced telomere shortening.

Research Products

• [Journal Article] Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia. (2013)
  • Author(s): Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
  • Journal Title: Neuropsychopharmacology. Volume: 38(8) Pages: 1409-1425
  • DOI: 10.1038/npp.2013.38
  • Peer Reviewed / Open Access
• [Journal Article] Su(fu) switches Rdx functions to fine-tune hedgehog signaling in the Drosophila wing disk. (2013)
  • Author(s): Seong KH & Ishii S
  • Journal Title: Genes Cells Volume: 18 Pages: 66-78
  • DOI: 10.1111/gtc.12018
  • Peer Reviewed
• [Journal Article] Inheritance and memory of stress-induced epigenome change: roles played by the ATF-2 family of transcription factors (2012)
  • Author(s): Seong KH, Maekawa T & Ishii S
  • Journal Title: Genes Cells. Volume: 17 Pages: 249-263
  • DOI: 10.1111/j.1365-2443.2012.01587.x
  • Peer Reviewed
• [Journal Article] Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation. (2012)
  • Author(s): Kanei-Ishii C, Nomura T, Egoh A & Ishii S
  • Journal Title: Biochem Biophys Res Commun. Volume: 426 Pages: 59-64
  • DOI: 10.1016/j.bbrc.2012.08.032
  • Peer Reviewed
• [Presentation] ストレスによるエピゲノム変化の遺伝 (2012)
  • Author(s): 石井俊輔
  • Organizer: 第85回日本生化学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] Deficiency of Schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia (2012)
  • Author(s): 宮川剛, 高雄啓三, 萩原英雄, 大平耕司, 昌子浩孝, 服部聡子, 小清水久嗣, 梅森十三, 高木豪, 石井俊輔
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14
• [Presentation] マクロファージの炎症時におけるATF-7の機能解析 (2012)
  • Author(s): 吉田圭介, 前川利男, Renard-Guillet Claire, 白髭克彦, 石井俊輔
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-13
• [Presentation] 転写因子ATF-7を介したストレスによるテロメアの長さの制御 (2012)
  • Author(s): 前川利男,劉彬彬, 吉田圭介, 仲村賢一, 田久保海誉, 石井俊輔
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-13
• [Presentation] ショウジョウバエにおけるストレス依存的エピジェネティック制御とその遺伝の解析 (2012)
  • Author(s): 成耆鉉,李棟, 中邑亮一, 石井俊輔
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-12
• [Presentation] Role of ATF-2 family transcription factors in inheritance of epigenetic change induced by stress (2012)
  • Author(s): 石井俊輔
  • Organizer: 第45回日本発生生物学会・第64回日本細胞生物学会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2012-05-31
• [Remarks]
  • URL: http://rtcweb.rtc.riken.jp/lab/mg/mg.html