| Project/Area Number |
24657055
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
ITO Etsuro 徳島文理大学, 薬学部, 教授 (80203131)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 学習 / 記憶 / 環状アデノシン一リン酸 / cAMP / 単一細胞 / 学習記憶 / モノアラガイ |
|---|
| Research Abstract |
It has been hypothesized that cAMP concentration would be increased in a presynaptic neuron in the brain during the learning process. However, nobody has succeeded in measuring this cAMP concentration in a single neuron. To address this issue, we attempted to develop the measurement system in the key single neuron of the pond snail Lymnaea stagnalis. When we applied the super-sensitive measurement method by combination of an ELISA method and an enzymatic cycling method, we clarified that the cAMP concentration can be measured in a single neuron. We should continue to examine the change in this cAMP concentration in a single neuron in the brain by a learning procedure.
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