| Project/Area Number |
24657069
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KUNIEDA Takekazu 東京大学, 理学(系)研究科(研究院), 助教 (10463879)
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| Co-Investigator(Renkei-kenkyūsha) |
KUBO Takeo 東京大学, 大学院理学系研究科, 教授 (10201469)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 緩歩動物 / 乾燥耐性 / 熱可溶性 / クマムシ / ミトコンドリア / 耐性 / 蛋白質 / 乾眠 |
|---|
| Research Abstract |
Limno-terrestrial tardigrades can tolerate severe desiccation by entering an ametabolic dehydrated state called anhydrobiosis. Here, we focused and analyzed properties of novel proteins abundantly expressed in anhydrobiotc tardigrades as candidates involved in anhydrobiosis. A1 is the most abundantly expressed transcript and its protein products turned out to form an aggregated complex in a spiral shape. This aggregated structure could provide physical support to desiccating cells. We also identified a novel heat-soluble protein from less tolerant tardigrade species and showed the amount of heat-soluble proteins can correlate with tolerant ability of the species. Furthermore, as a candidate involved in protection of mitochondria against desiccation, novel mitochondrial proteins were identified.
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