| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Elucidation of molecular mechanism of protein translocation across cell membranes is fundamentally important for cell biology. Several different type of protein translocation machineries called translocons have been so far identified and characterized. Among them, only bacterial-type SEC translocons have been extensively studied from the structural aspects simply because of some difficulty to obtain high amount of purified translocons of eukaryotic-type. In this study, we have successfully purified TIC translocon at the inner envelope membrane of chloroplast as well as its associated import motor complex.
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