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Molecular mechanism that links a nutrient-responsive miRNA with clock genes

Research Project

Project/Area Number 24657081
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Functional biochemistry
Research InstitutionThe University of Tokyo

Principal Investigator

KATADA TOSHIAKI  東京大学, 薬学研究科(研究院), 教授 (10088859)

Co-Investigator(Kenkyū-buntansha) FUKUYAMA Masamitsu  東京大学, 大学院薬学系研究科, 助教 (20422389)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsmicroRNA / 時計遺伝子 / 栄養感知 / 線虫 / シグナル伝達 / 栄養応答
Research Abstract

Although the microRNA (miRNA) miR-92 and its paralogues have been known to be associated with tumorigenesis, their physiological role and the signaling pathway in which they function remain to be delineated. In this study, we explored the relationship between the miR-92 family of miRNAs and the clock genes, using the nematode C. elegans and mammalian cultured cells.
We found several lines of evidence suggesting that C. elegans miR-92 orthologue, miR-235 and the clock gene Period2 ortholog lin-42 negatively regulate each other to determine the timing of differentiation in progenitor cells. On the other hand, miR-92 and one of its paralogues did not show oscillatory expression pattern in cultured rodent fibroblasts.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (35 results)

All 2014 2013 2012 Other

All Journal Article (14 results) (of which Peer Reviewed: 13 results,  Open Access: 1 results) Presentation (14 results) (of which Invited: 1 results) Remarks (7 results)

  • [Journal Article] 幹・前駆細胞の栄養応答とその分子機構の最前線インスリン経路とマイクロRNAの関与2014

    • Author(s)
      福山征光
    • Journal Title

      ファルマシア

      Volume: 50 Pages: 512-516

    • NAID

      130005160520

    • URL

      http://farumashia.pharm.or.jp/mokuji/2014/50-06.html

    • Related Report
      2013 Final Research Report
  • [Journal Article] The microRNA miR-235 couples blast cell quiescence to the nutritional state.2013

    • Author(s)
      Kasuga H, Fukuyama M, Kitazawa A, Kontani K. Katada T.
    • Journal Title

      Nature

      Volume: 497 Issue: 7450 Pages: 503-506

    • DOI

      10.1038/nature12117

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia2013

    • Author(s)
      Su S, Phua SC, DeRose R, Chiba S, Narita K, Kalugin PN, Katada T, Kontani K, Takeda S, Inoue T.
    • Journal Title

      Nat. Methods

      Volume: 10 Issue: 11 Pages: 1105

    • DOI

      10.1038/nmeth.2647

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain.2013

    • Author(s)
      Cevik S, Sanders AA, Van Wijk E, Boldt K, Clarke L, van Reeuwijk J, Hori Y, Horn N, Hetterschijt L, Wdowicz A, Mullins A, Kida K, Kaplan OI, van Beersum SE, Man Wu K, Letteboer SJ, Mans DA, Katada T, Kontani K, Ueffing M, Roepman R, Kremer H, Blacque OE.
    • Journal Title

      PLoS Genet.

      Volume: 9 Issue: 12 Pages: e1003977-e1003977

    • DOI

      10.1371/journal.pgen.1003977

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article]2013

    • Author(s)
      Kawazu M, Ueno T, Kontani K, Ogita Y, Ando M, Fukumura K, Yamato A, Soda M, Takeuchi K, Miki Y, Yamaguchi H, Yasuda T, Naoe T,Yamashita Y, Katada T, Choi YL, Mano H,
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 110 Issue: 8 Pages: 3029-3034

    • DOI

      10.1073/pnas.1216141110

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Arl8/ARL-8 functions in apoptotic cell removal by mediating phagolysosome formation in C. elegans.2013

    • Author(s)
      Sasaki A
    • Journal Title

      Mol Biol Cell.

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin2012

    • Author(s)
      Kajiho, H., et al.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 1 Pages: e30575-e30575

    • DOI

      10.1371/journal.pone.0030575

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents.2012

    • Author(s)
      Hata S
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Pages: 22089-22098

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuronally expressed Ras-family GTPase Di-Ras modulates synaptic activity in Caenorhabditis elegans2012

    • Author(s)
      Tada M, Gengyo-Ando K, Kobayashi T, Fukuyama M, Mitani S, Kontani K, Katada T
    • Journal Title

      Genes Cells

      Volume: 17(9) Issue: 9 Pages: 778-89

    • DOI

      10.1111/j.1365-2443.2012.01627.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] C. elegans AMPKs promote survival and arrest germline development during nutrient stress.2012

    • Author(s)
      Fukuyama M., et al.
    • Journal Title

      Bio. Open

      Volume: 1 Issue: 10 Pages: 929-936

    • DOI

      10.1242/bio.2012836

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities2012

    • Author(s)
      Hara-Yokoyama M., Kukimoto-Niino M., Terasawa K., Harumiya S., Podyma-Inoue K. A., Hino N., Sakamoto K., Itoh S., Hashii N., Hiruta Y., Kawasaki N., Mishima-Tsumagari C., Kaitsu Y., Matsumoto T., Wakiyama M., Shirouzu M., Kasama T., Ta
    • Journal Title

      Structure

      Volume: 20 Issue: 9 Pages: 1585

    • DOI

      10.1016/j.str.2012.06.017

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biological role of the two overlapping poly(A)-binding protein interacting motifs 2 (PAM2) of eukaryotic releasing factor eRF3 in mRNA decay.2012

    • Author(s)
      Osawa M, Hosoda N, Nakanishi T, Uchida N, Kimura T, Imai S, Machiyama A, Katada T, Hoshino S, Shimada I.
    • Journal Title

      RNA

      Volume: 18 Issue: 11 Pages: 1957-1967

    • DOI

      10.1261/rna.035311.112

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The inhibitory G protein G(i) identified as pertussis toxin-catalyzed ADP-ribosylation.2012

    • Author(s)
      Katada T
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 35 Pages: 2103-2111

    • NAID

      130002480519

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine2012

    • Author(s)
      Takasuga , Wada et al.
    • Journal Title

      PNAS 110

      Volume: 1726-1731 Issue: 5 Pages: 1726-31

    • DOI

      10.1073/pnas.1213212110

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 線虫のマイクロRNA miR-235は幼生発生開始の栄養チェックポイントとして機能する2013

    • Author(s)
      福山征光、春日秀文、北澤文、小川拓也、粂優彦、紺谷圏二、堅田利明
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-04
    • Related Report
      2013 Final Research Report
  • [Presentation] microRNAであるmiR-235は前駆細胞の休眠と栄養状態を結びつける2013

    • Author(s)
      福山征光、春日秀文、北澤文、紺谷圏ニ、堅田利明
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Year and Date
      2013-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] The microRNA miR-235 suspends growth and development during starvation2013

    • Author(s)
      Fukuyama, M., Kasuga, H., Kitazawa, A., Kume, M., Ogawa, T., Kontani, K., Katada, T.
    • Organizer
      第46回日本発生生物学会
    • Place of Presentation
      松江
    • Year and Date
      2013-05-31
    • Related Report
      2013 Final Research Report
  • [Presentation] インスリン経路を介した芽細胞休眠制御に関与するmicroRNA mir-235の同定と解析2012

    • Author(s)
      春日秀文、福山征光、北澤文、紺谷圏二、堅田利明
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 休眠時に高発現して発生停止を維持するmicroRNA2012

    • Author(s)
      福山征光、春日秀文、北澤文、紺谷圏二、堅田利明
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪
    • Year and Date
      2012-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 線虫のマイクロRNA miR-235は幼生発生開始の栄養チェックポイントとして機能する

    • Author(s)
      福山征光、春日秀文、北澤文、小川拓也、粂優彦、紺谷圏二、堅田利明
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] microRNAであるmiR-235は前駆細胞の休眠と栄養状態を結びつける

    • Author(s)
      福山 征光、春日 秀文、北澤 文、紺谷 圏ニ、堅田 利明
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山大学(岡山県・岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The microRNA mir-235 suspends growth and development during starvation

    • Author(s)
      福山 征光、春日 秀文、北澤 文、粂優彦、小川拓也、紺谷 圏ニ、堅田 利明
    • Organizer
      第46回日本発生生物学会
    • Place of Presentation
      島根県立産業交流会館(島根県・松江市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ethanol and essential amino acids can trigger postembryonic development through the insulin/IGF pathway.

    • Author(s)
      Fukuyama M
    • Organizer
      5th East Asia C. elegans meeting.
    • Place of Presentation
      台北、台湾
    • Related Report
      2012 Research-status Report
  • [Presentation] 繊毛形成・機能に介在するARLファミリー低分子量Gタンパク質の解析

    • Author(s)
      紺谷圏二
    • Organizer
      第3回繊毛研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 低分子量G蛋白質Sar1の活性制御によるコラーゲン分泌機構の解明

    • Author(s)
      齋藤 康太
    • Organizer
      第11回生命科学研究会
    • Place of Presentation
      秋田
    • Related Report
      2012 Research-status Report
  • [Presentation] 休眠時に高発現して発生停止を維持するmicroRNA

    • Author(s)
      福山 征光
    • Organizer
      日本動物学会 第83回大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] インスリン経路を介した芽細胞休眠制御に関与するmicroRNAmir-235の同定と解析

    • Author(s)
      春日 秀文
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] アティピカルRasファミリーGタンパク質Di-Rasの機能解析

    • Author(s)
      紺谷 圏二
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Remarks] 春日秀文・福山征光.ライフサイエンス新着論文レビュー"First Author's"

    • URL

      http://first.lifesciencedb.jp/archives/7163

    • Related Report
      2013 Final Research Report
  • [Remarks] 福山 征光.日本学術振興会ウェブページ「事業の成果」

    • URL

      https://www.jsps.go.jp/seika/2013/vol3_003.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 福山 征光.科研費NEWS 2013年度VOL.3 P.17.「マイクロRNAによる前駆細胞の栄養応答性調節機構の研究」

    • URL

      http://www.jsps.go.jp/j-grantsinaid/22_letter/data/news_2013_vol3/news_2013_vol3.pdf

    • Related Report
      2013 Final Research Report
  • [Remarks] 福山 征光、春日 秀文、北澤 文、小川 拓也、粂 優彦、紺谷 圏二、堅田 利明.東京大学プレスリリース(平成25年5月8日)「栄養不足が発育をさまたげるしくみ―低栄養状態に応答し前駆細胞の活性化を阻害する遺伝子を発見―」

    • URL

      http://www.u-tokyo.ac.jp/public/public01_250508_02_j.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京大学・大学院薬学系研究科 生理化学教室ホームページ

    • URL

      http://www.f.u-tokyo.ac.jp/~seiri/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京大学プレスリリース

    • URL

      http://www.u-tokyo.ac.jp/public/public01_250508_02_j.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 生理化学教室のホームページ

    • URL

      http://www.f.u-tokyo.ac.jp/~seiri/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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