Molecular mechanism that links a nutrient-responsive miRNA with clock genes
| Project/Area Number |
24657081
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATADA TOSHIAKI 東京大学, 薬学研究科(研究院), 教授 (10088859)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUYAMA Masamitsu 東京大学, 大学院薬学系研究科, 助教 (20422389)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | microRNA / 時計遺伝子 / 栄養感知 / 線虫 / シグナル伝達 / 栄養応答 |
|---|
| Research Abstract |
Although the microRNA (miRNA) miR-92 and its paralogues have been known to be associated with tumorigenesis, their physiological role and the signaling pathway in which they function remain to be delineated. In this study, we explored the relationship between the miR-92 family of miRNAs and the clock genes, using the nematode C. elegans and mammalian cultured cells.
We found several lines of evidence suggesting that C. elegans miR-92 orthologue, miR-235 and the clock gene Period2 ortholog lin-42 negatively regulate each other to determine the timing of differentiation in progenitor cells. On the other hand, miR-92 and one of its paralogues did not show oscillatory expression pattern in cultured rodent fibroblasts.
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Report
(3 results)
Research Products
(35 results)
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[Journal Article] Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain.2013
Author(s)
Cevik S, Sanders AA, Van Wijk E, Boldt K, Clarke L, van Reeuwijk J, Hori Y, Horn N, Hetterschijt L, Wdowicz A, Mullins A, Kida K, Kaplan OI, van Beersum SE, Man Wu K, Letteboer SJ, Mans DA, Katada T, Kontani K, Ueffing M, Roepman R, Kremer H, Blacque OE.
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Journal Title
PLoS Genet.
Volume: 9
Issue: 12
Pages: e1003977-e1003977
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article]2013
Author(s)
Kawazu M, Ueno T, Kontani K, Ogita Y, Ando M, Fukumura K, Yamato A, Soda M, Takeuchi K, Miki Y, Yamaguchi H, Yasuda T, Naoe T,Yamashita Y, Katada T, Choi YL, Mano H,
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Journal Title
Proc Natl Acad Sci U S A
Volume: 110
Issue: 8
Pages: 3029-3034
DOI
Related Report
Peer Reviewed
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[Journal Article] Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities2012
Author(s)
Hara-Yokoyama M., Kukimoto-Niino M., Terasawa K., Harumiya S., Podyma-Inoue K. A., Hino N., Sakamoto K., Itoh S., Hashii N., Hiruta Y., Kawasaki N., Mishima-Tsumagari C., Kaitsu Y., Matsumoto T., Wakiyama M., Shirouzu M., Kasama T., Ta
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Journal Title
Structure
Volume: 20
Issue: 9
Pages: 1585-1595
DOI
Related Report
Peer Reviewed
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[Presentation] The microRNA miR-235 suspends growth and development during starvation2013
Author(s)
Fukuyama, M., Kasuga, H., Kitazawa, A., Kume, M., Ogawa, T., Kontani, K., Katada, T.
Organizer
第46回日本発生生物学会
Place of Presentation
松江
Year and Date
2013-05-31
Related Report
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