| Project/Area Number |
24657085
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Tokyo Institute of Technology |
|---|
Principal Investigator |
HIROSE Shigehisa 東京工業大学, 大学院・生命理工学研究科, 教授 (10134199)
|
|---|
| Project Period (FY) |
2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
|
|---|
| Keywords | 酵素の調節 / 代謝調節 / ルート効果ヘモグロビン / 解糖系 / 乳酸輸送体 / Fructose bisphosphatase / 空転サイクル / 熱発生 / 対向流血管系 / ガス腺 |
|---|
| Research Abstract |
H+/monocarboxylate transporters MCT1b and MCT4b were found to be highly expressed in the fugu swimbladder. Immunohistochemical analyses of metabolic enzymes demonstrated that a gluconeogenesis enzyme fructose-1,6-bisphosphatase (Fbp1) and a glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (Gapdh) are highly expressed in gas gland cells. The simultaneous catalyses of glycolysis and gluconeogenesis reactions suggest the presence of a futile cycle in gas gland cells to maintain the levels of ATP low and to generate heat that helps reduce the solubility of O2
|
