| Project/Area Number |
24657088
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
HANAFUSA Hiroshi 名古屋大学, 理学(系)研究科(研究院), 講師 (00345844)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞極性 / LRRK1 / スピンドル配向 / 非対称分裂 / Spindle orientation / NuMA / Dynein |
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| Research Abstract |
Asymmetric cell division is an important mechanism that regulates growth or differentiation of stem cells. In this project, we tried to reveal the role of important factors in asymmetric cell division by using the artificially induced polarization of HeLa cells, in which expressed the chimera molecules between Echinoid, an cell-cell adhesion molecule, and a factor, which activates the polarization signal pathway. We found that ROCO family kinase LRRK1 plays an important role in the control of the axis of cell division by regulating the mitotic spindle.
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