rigidity sensing and axonal growth guidance
| Project/Area Number |
24657105
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|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biophysics
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| Research Institution | Kyushu University |
|---|
Principal Investigator |
MIZUNO daisuke 九州大学, 理学(系)研究科(研究院), 准教授 (30452741)
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|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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|---|
| Keywords | rigidity sensing / マイクロレオロジー / 神経突起 / 3次元培養 / ベシクル / 軸索伸張 / mechanotaxis / 力学知覚 / 神経細胞 / 光トラップ |
|---|
| Research Abstract |
Cellular forces and intra- and extra-cellular environments profoundly affects various cell behaviors. Recently, it has been understood that cells measure the rigidity of surrounding media using their own stiffness as a reference. In this study, we performed microrheology study in order to investigate the unique mechanism of the mechano-taxis during the axonal growth guidance. We cultured neurons in collagen gels together with the vesicles and microgels including the chemical cue for the axonal growth. We further developed the technology in order to control the 3D arrangements of cells and microgels.
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Report
(3 results)
Research Products
(80 results)
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[Presentation] Non-Gauss athermal fluctuations in Bacterial bath2014
Author(s)
Masato Aridome, takasi kurihara, Heev Ayade, Irwin Zaid, Daisuke Mizuno
Organizer
国際学会, KITP conference "Active Processes in Living and Nonliving Matter"
Place of Presentation
Kavli Institute for Theoretical Physics, University of California, Santa Barbara, USA(poster)
Year and Date
2014-02-12
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[Presentation] Non-Gauss athermal fluctuations in Bacterial bath
Author(s)
Masato Aridome, takasi kurihara, Heev Ayade, Irwin Zaid, Daisuke Mizuno
Organizer
KITP conference "Active Processes in Living and Nonliving Matter"
Place of Presentation
Kavli Institute for Theoretical Physics, University of California, Santa Barbara, USA
Related Report
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