Regulation of alternative splicing in response to heat-stress

Research Project

Project/Area Number	24657118
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Molecular biology
Research Institution	Kobe University
Principal Investigator	INOUE Kunio 神戸大学, 理学(系)研究科(研究院), 教授 (40252415)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	遺伝子 / 発現制御 / 細胞環境 / スプライシング
Research Abstract	It is known that RNA splicing is repressed in response to heat-stress. Here we examined if the U1 snRNP-independent splicing plays a role in efficient splicing of hsp genes under heat condition. Moreover, we identified an RNA-binding protein required for induction of alternative splicing of hsp105 in response to heat-stress.